Deep brain stimulation (DBS) in the thalamus for the treatment of tremor was
approved by the FDA in 1997 following the pioneering work of Benabid and
colleagues in France. Subsequently it has been found that stimulation in the
subthalamic nucleus (STN) or globus pallidus (GPi) can relieve multiple
symptoms of Parkinson"s disease (PD). DBS has been successful in restoring
significant mobility to a large number of patients with advanced PD. During
the past year, GPi and STN stimulation underwent review at the FDA for
potential use to decrease symptoms of dyskinesia, tremor, postural
instability, and/or bradykinesia in individuals with advanced PD.
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Expiration Date: Wednesday, November 21, 2001 NOFO Number: RFA-NS-02-004 Release Date: Friday, July 27, 2001 Notice Type: RFA
Expiration Date: Thursday, November 22, 2001 NOFO Number: RFA-DK-01-032 Release Date: Friday, July 27, 2001 Notice Type: RFA
The National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK), the National Institute of Neurological Disorders and Stroke
(NINDS), the National Institute of Child Health and Human Development
(NICHD), the National Institute of Nursing Research (NINR) and the
Juvenile Diabetes Research Foundation International (JDRF) solicit
applications for clinical studies designed to enhance understanding and
prevention of hypoglycemia in patients with diabetes. Large clinical
trials have demonstrated the efficacy of intensified glucose control in
the prevention of the long-term complications of diabetes. However,
episodes of severe hypoglycemia may complicate intensified treatment
and are often a major obstacle to the achievement of euglycemia in many
patients. This RFA solicits clinical studies to 1) define and
characterize hypoglycemia in diabetic individuals and 2) develop new
approaches to prevent the development of hypoglycemia or to ameliorate
its effects in individuals with diabetes.
Expiration Date: Saturday, July 31, 2004 NOFO Number: PAR-01-118 Release Date: Wednesday, July 25, 2001 Notice Type: PAR
The NINDS seeks to fund high quality clinical trials to evaluate treatments for
neurological disorders. The NINDS Clinical Trial Planning Grant allows for
early peer review of the rationale and design for clinical trials of treatments
for neurological disorders and provides support for the development of a
detailed clinical trial research plan, including a complete manual of operations
and procedures.
Expiration Date: Saturday, July 31, 2004 NOFO Number: PAR-01-119 Release Date: Wednesday, July 25, 2001 Notice Type: PAR
The NINDS is committed to identifying effective treatments for neurological
disorders by supporting well-executed clinical trials. Before proceeding to a
full-scale clinical trial, pilot clinical studies are often required. The NINDS
announces its interest in supporting pilot studies required to obtain necessary
information to clearly establish the clinical basis for proceeding to a full-
scale trial. The purpose of PILOT STUDIES FOR CLINICAL TRIALS IN NEUROLOGICAL
DISORDERS grant (for brevity referred to as NINDS Pilot Studies grant) is to
obtain preliminary data and conduct studies to support the rationale for a
subsequent full-scale clinical trial of an intervention to treat or prevent
neurological disease.
Expiration Date: Thursday, October 25, 2001 NOFO Number: RFA-MH-01-012 Release Date: Tuesday, July 24, 2001 Notice Type: RFA
The National Institute of Mental Health (NIMH) and National Institute of
Neurological Disorders and Stroke (NINDS) invite grant applications for the
formation of cross-disciplinary networks of scientists interested in studying
the etiology of Attention-deficit/Hyperactivity Disorder (ADHD) and its
implications for the disorders nosology, assessment and treatment. These
research networks will allow the formation of novel collaborations among
neuroscientists, behavioral scientists, and clinical scientists in order to
develop integrative and cutting edge research project grant applications.
These networks are intended to facilitate the connection between etiologic
theory and ADHD assessment techniques and treatment procedures. Networks must
include representation from multiple perspectives that, at a minimum, span
expertise across levels of analysis (e.g., molecular to behavioral) and
disciplines (e.g., behavioral science, neuroscience, genetics, psychiatry,
pediatrics).
Expiration Date: Saturday, November 17, 2001 NOFO Number: RFA-NS-02-007 Release Date: Thursday, July 19, 2001 Notice Type: RFA
The goal of this Request for Applications (RFA) is to accelerate the
translation of gene transfer methodologies into the clinic. Gene therapy
holds tremendous promise for the treatment of neurological disorders.
Despite recent advances in this area however, specific scientific,
technological, and safety goals must be achieved before gene transfer becomes
a viable therapeutic alternative. Current needs include more effective
methods for controlling the expression of therapeutic transgenes in the
brain, better strategies for vector delivery and monitoring transgene
expression, more studies addressing the toxicity of specific vector/transgene
combinations, and greater knowledge of the long term effects of expressing
specific transgenes in the nervous system. This RFA is intended to encourage
research projects that address these or related translational issues in the
context of specific neurological disorders.
Expiration Date: Wednesday, November 21, 2001 NOFO Number: RFA-NS-02-003 Release Date: Tuesday, July 17, 2001 Notice Type: RFA
Deep brain stimulation (DBS) in the thalamus for the treatment of tremor was
approved by the FDA in 1997 following the pioneering work of Benabid and
colleagues in France. Subsequently it has been found that stimulation in the
subthalamic nucleus (STN) or globus pallidus (GPi) can relieve multiple
symptoms of Parkinson"s disease (PD). DBS has been successful in restoring
significant mobility to a large number of patients with advanced PD. GPi and
STN stimulation are currently being considered for use to decrease symptoms of
dyskinesia, tremor, postural instability, and/or bradykinesia in individuals
with advanced PD.
Expiration Date: Saturday, July 31, 2004 NOFO Number: PA-01-115 Release Date: Monday, July 2, 2001 Notice Type: PA
The National Institute of Nursing Research and co-sponsoring Institutes and
Centers encourage research proposals in the management of chronic pain across
the lifespan. Pain is a subjective experience influenced by gender, age,
race/ethnicity and psychosocial factors. The management of pain is influenced
by patient, health care provider and system factors. Research is needed to
determine the most effective interventions to remove barriers to effective
treatment, to determine the most effective pharmacological and non-
pharmacological therapies including complementary and alternative therapies,
to identify assessment tools for patients unable to verbalize their pain, and
to identify effective pain management strategies for individuals with
disabilities and underserved populations.
Expiration Date: Friday, November 16, 2001 NOFO Number: RFA-NS-02-010 Release Date: Monday, July 2, 2001 Notice Type: RFA
The Neurodegeneration and Clinical Trial Groups of the National
Institute of Neurological Disorders and Stroke (NINDS) request
applications for clinical centers to collaborate in the performance of
a large, double-blind randomized trial of two or more potential
neuroprotective agents in patients early in the course of Parkinsons
disease. Applications for coordinating and statistical centers were
requested in a separate solicitation
(http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-01-012.html). The
trial was called for in the NIH Parkinson Research Agenda
(http://www.ninds.nih.gov/about_ninds/nihparkinsons_agenda.htm). The
neuroprotectants to be tested in the trial have not yet been chosen and
will be selected by an NINDS-appointed Oversight Committee from among
those proposed by the applicants who respond to this Request for
Applications (RFA) as well as from those suggested by others, including
NINDS grantees, pharmaceutical companies, patients, and patient
advocates.
Expiration Date: Saturday, October 2, 2004 NOFO Number: PA-01-112 Release Date: Friday, June 29, 2001 Notice Type: PA
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),
the National Eye Institute (NEI), the National Heart, Lung and Blood
Institute (NHLBI), the National Institute on Aging (NIA), the National
Institute of Neurological Disorders and Stroke (NINDS) and the Office of
Dietary Supplements (ODS) seek basic and clinical research applications to
study the use of vitamin E and other antioxidants in the prevention or
amelioration of diabetic complications.