The above sponsoring Institutes invite applications in response to this
Program Announcement (PA) that will enhance our understanding of the etiology,
extent, services, treatment, management, and prevention of child neglect. This
PA is a follow-up to a 1999 Request for Applications designed to stimulate the
development of programs of child neglect research at institutions that
currently have strong research programs in related areas, and to bring the
expertise of researchers from the child health, education, and juvenile
justice fields into the child neglect research field. The PA is intended to
foster ongoing programs of research on child neglect throughout NIH, the DOJ
Office of Juvenile Justice and Delinquency Prevention, the Children"s Bureau,
and the ED Office of Special Education Programs, in order to encourage the
continuation of the kind of research stimulated by the 1999 RFA. (The Office
of Child Abuse and Neglect, in the Children"s Bureau, will participate pending
the reauthorization of the Child Abuse Prevention and Treatment Act and the
availability of funds.)
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Expiration Date: Tuesday, March 2, 2004 NOFO Number: PA-01-060 Release Date: Wednesday, February 28, 2001 Notice Type: PA
Expiration Date: Wednesday, May 16, 2001 NOFO Number: RFA-NS-01-012 Release Date: Tuesday, February 27, 2001 Notice Type: RFA
The Neurodegeneration and Clinical Trial Groups of the National
Institute of Neurological Disorders and Stroke (NINDS) request
applications for centers to collaborate in the performance of a large,
double-blind randomized trial of two or more potential neuroprotective
agents in patients early in the course of Parkinsons disease. Two
types of applications are requested: for (1) a Coordinating Center,
and (2) a Statistical Center. Applications for multiple Clinical
Centers will be sought in a separate solicitation. The trial was
called for in the NIH Parkinson Research Agenda
(http://www.ninds.nih.gov/about_ninds/nihparkinsons_agenda.htm). The
neuroprotectants to be tested in the trial have not yet been chosen and
will be selected from among those proposed by the applicants who
respond to this Request for Applications (RFA) as well as from those
suggested by others, including NINDS grantees, pharmaceutical
companies, patients, and patient advocates.
Expiration Date: Saturday, July 14, 2001 NOFO Number: RFA-NS-02-001 Release Date: Tuesday, February 13, 2001 Notice Type: RFA
The National Institute of Neurological Disorders and Stroke (NINDS) and the
National Institute of Mental Health (NIMH) invite applications for support of
Microarray Centers. These Centers will support gene expression profiling in the
nervous system through the application of microarray technologies. The
Microarray Centers, which will function as a consortium, will provide reagents,
services, and training to the neuroscience community, on a fee-for-service
basis. The term consortium is used here to refer to the Centers that are
funded through this RFA, and not to refer to non-grantee, participating
organizations.
Expiration Date: Tuesday, March 16, 2004 NOFO Number: PA-01-051 Release Date: Tuesday, February 13, 2001 Notice Type: PA
The purpose of this program announcement is to encourage grant
applications for the support of research designed to elucidate the
diagnosis, epidemiology, etiology, genetics, treatment, and optimal
means of service delivery in relation to Autistic Disorder ("autism")
and autism spectrum disorders (Rett"s Disorder, Childhood
Disintegrative Disorder, Asperger"s Disorder, Pervasive Developmental
Disorder-Not Otherwise Specified, or "Atypical Autism").
Expiration Date: Wednesday, July 11, 2001 NOFO Number: RFA-AI-01-005 Release Date: Monday, February 12, 2001 Notice Type: RFA
The National Institute of Allergy and Infectious Diseases
(NIAID), the National Institute of Neurological Disorders and Stroke
(NINDS), the National Institute of Arthritis and Musculoskeletal and
Skin Diseases (NIAMS), the Office of Research on Womens Health (ORWH)
of the National Institutes of Health (NIH) and the National Multiple
Sclerosis Society (NMSS) invite applications to identify, characterize,
and define differences in the immune response between males and females,
including responses to exogenous and self-antigens, the innate and
adaptive immune response, systemic and mucosal immune response, and
regulation of the immune system by hormonal and non-hormonal sex
differences. The intent of this Request for Applications (RFA) is to
support multidisciplinary research on sex-based differences in immune
responses that may be important in autoimmune diseases, including
multiple sclerosis (MS), rheumatic diseases such as rheumatoid arthritis
(RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc),
as well as other immune mediated diseases, and the underlying mechanisms
and clinical significance of such differences. Collaborative
multidisciplinary research, involving investigators with expertise in
various scientific disciplines and clinical specialties is encouraged.
Both human studies and animal models with relevance to human disease are
appropriate. Research that expands basic and clinical knowledge of the
effect of sex, including hormonal and non-hormonal differences, on the
immune response will facilitate development of improved therapeutic and
preventive strategies for autoimmune diseases and other immune-mediated
disorders. The focus of this RFA is the biological or physiological sex
differences between males and females, studies of the cultural, social,
and historical differences between males and females ("gender
differences") are not responsive to this RFA.
Expiration Date: Thursday, July 12, 2001 NOFO Number: RFA-HD-01-008 Release Date: Wednesday, January 31, 2001 Notice Type: RFA
This Request for Applications (RFA) solicits research grant applications to
examine the feasibility of using Xenopus tropicalis for standard genetic
manipulations. The research proposed should optimize the conditions required
to perform efficient, large-scale mutagenesis, and should use the optimized
parameters to perform small-scale mutagenesis, phenotyping, and gene cloning,
identification, and characterization. Mutant animals, protocols, and data
produced by these projects should be made available to the scientific
community. We anticipate that the mutants, data and procedures developed by
the projects funded under this RFA will enable Xenopus tropicalis to play a
significant role in identifying and characterizing genes that regulate
cellular and developmental processes.
Expiration Date: Thursday, April 12, 2001 NOFO Number: RFA-DA-01-011 Release Date: Thursday, January 25, 2001 Notice Type: RFA
This RFA solicits proposals for development of tools and techniques for
the establishment of random and targeted sequence-tagged insertion
libraries of embryonic stem (ES) cells that can be used to generate
mutant mice in which the expression of the tagged gene could be
controlled temporally and spatially. The development of such a
resource for wide distribution to the scientific community would make
it possible to scan the sequence database for any gene of interest and
order the corresponding targeted ES cell line. Ideally, the
insertional mutagenesis system developed would permit a wide range of
genetic analyses and manipulations, including enhancer-trapping,
conditional knockouts, conditional expression or overexpression, etc.
It also would permit the larger community of investigators to utilize
genomic resources efficiently.
Expiration Date: Thursday, April 12, 2001 NOFO Number: RFA-DA-01-012 Release Date: Thursday, January 25, 2001 Notice Type: RFA
This Request for Applications (RFA) solicits proposals for development of
tools and techniques for the establishment of random and targeted sequence-
tagged insertion libraries of embryonic stem (ES) cells that can be used to
generate mutant mice in which the expression of the tagged gene could be
controlled temporally and spatially. The development of such a resource for
wide distribution to the scientific community would make it possible to scan
the sequence database for any gene of interest and order the corresponding
targeted ES cell line. Ideally, the insertional mutagenesis system developed
would permit a wide range of genetic analyses and manipulations, including
enhancer-trapping, conditional knockouts, conditional expression or
overexpression, etc. It also would permit the larger community of
investigators to utilize genomic resources efficiently.
Expiration Date: Sunday, February 1, 2004 NOFO Number: PA-01-043 Release Date: Thursday, January 18, 2001 Notice Type: PA
The overall goal of this initiative is to invite qualified researchers to
submit new research grant applications to conduct mechanistic studies using
patients, patient materials or information from multi-site pediatric drug
trials sponsored by the National Institute of Child Health and Human
Development (NICHD), National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK), National Institute of Mental Health (NIMH), and the
National Institute of Neurological Disorders and Stroke (NINDS).
Expiration Date: Sunday, January 4, 2004 NOFO Number: PAS-01-041 Release Date: Thursday, January 4, 2001 Notice Type: PAS
The National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS) and the National Institute of Neurological Disorders and Stroke
(NINDS) encourage investigator-initiated research grant applications of
therapeutic and pathogenic approaches for the muscular dystrophies.
Responses to this program announcement may include studies in appropriate
animal models or preclinical or clinical studies in patients with Duchenne
muscular dystrophy (DMD), Becker muscular dystrophy (BMD),
facioscapulohumeral dystrophy (FSHD), limb-girdle muscular dystrophy (LGMD),
myotonic dystrophy (DM), congenital muscular dystrophy (CMD), Emery-Dreifuss
muscular dystrophy (EMD), or other forms of muscular dystrophy.