The National Institute on Aging (NIA), National Institute of Child Health and
Human Development (NICHD), National Institute on Deafness and Other
Communication Disorders (NIDCD), National Institute of Dental and
Craniofacial Research (NIDCR), National Institute on Drug Abuse (NIDA),
National Eye Institute (NEI), National Institute of General Medical Sciences
(NIGMS), National Institute of Mental Health (NIMH), National Institute of
Neurological Disorders and Stroke (NINDS), and National Institute of Nursing
Research (NINR) are continuing joint sponsorship of a predoctoral research
training program in the neurosciences. The aim of the program is to encourage
and support broad, early-stage (pre-thesis) training in the neurosciences by
offering institutions a single comprehensive training grant. It is expected
that these training programs will contribute to basic and disease-related
neuroscience research that is relevant to the participating NIH Institutes.
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Expiration Date: Thursday, September 30, 2004 NOFO Number: PAR-02-017 Release Date: Tuesday, November 6, 2001 Notice Type: PAR
Expiration Date: Thursday, May 18, 2006 NOFO Number: PA-02-011 Release Date: Thursday, October 11, 2001 Notice Type: PA
Participating Institutes and Centers (ICs) of the National Institutes of Health
(NIH) invite applications for R01 awards to support Bioengineering Research
Grants (BRGs) for basic and applied multi-disciplinary research that addresses
important biological or medical research problems. The BRGs support multi-
disciplinary research performed in a single laboratory or by a small number of
investigators that applies an integrative, systems approach to develop knowledge
and/or methods to prevent, detect, diagnose, or treat disease or to understand
health and behavior. A BRG application may propose hypothesis-driven,
discovery-driven, developmental, or design-directed research at universities,
national laboratories, medical schools, large or small businesses, or other
public and private entities.
Expiration Date: Tuesday, August 13, 2002 NOFO Number: PAR-02-010 Release Date: Thursday, October 11, 2001 Notice Type: PAR
Participating Institutes and Centers (ICs) of the National Institutes of Health
(NIH) invite applications for R01 awards to support Bioengineering Research
Partnerships (BRPs) for basic and applied multi-disciplinary research that
addresses important biological or medical research problems. A BRP is a multi-
disciplinary research team applying an integrative, systems approach to develop
knowledge and/or methods to prevent, detect, diagnose, or treat disease or to
understand health and behavior. The partnership must include appropriate
bioengineering or allied quantitative sciences in combination with biomedical
and/or clinical investigators. A BRP may propose hypothesis-driven, discovery-
driven, developmental, or design-directed research at universities, national
laboratories, medical schools, large or small businesses, or other public and
private entities or combinations of these entities.
Expiration Date: Saturday, January 19, 2002 NOFO Number: RFA-NS-02-011 Release Date: Thursday, October 4, 2001 Notice Type: RFA
The National Institute of Neurological Disorders and Stroke (NINDS)
invites grant applications for the formation of cross-disciplinary
networks of scientists interested in studying the neural mechanisms of
cognition and other complex behaviors. These research networks will
allow the formation of novel collaborations among cognitive scientists,
neuroscientists, behavioral and computational neuroscientists, imaging
specialists and clinical scientists in order to develop integrative and
cutting edge research programs that advance our understanding of the
circuits and pathways of cognitive function. The research plan for
these networks must be driven by a cognitive neuroscience question
(e.g., neural mechanisms of attention, emotion, language acquisition,
memory, perception, sensorimotor integration in various model systems
and in various clinical populations) and must combine imaging
techniques with other psychophysiological methods. This RFA is intended
to begin a process where scientists from various disciplines can
overcome barriers to cross-disciplinary research agendas addressing the
dynamic nature of underlying physiological and cognitive systems.
Expiration Date: Wednesday, February 13, 2002 NOFO Number: RFA-HL-02-003 Release Date: Friday, September 7, 2001 Notice Type: RFA
This RFA supports novel basic research designed to elucidate effects of
whole-body ischemia and subsequent blood flow restoration on cardiovascular
and neurological function. The ultimate goal is to provide a rational basis
for development of effective new therapeutic strategies to restore heart
function and preserve neurological function after cardiopulmonary arrest.
Expiration Date: Tuesday, November 30, 2004 NOFO Number: PA-01-131 Release Date: Friday, August 31, 2001 Notice Type: PA
The National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS), the National Institute of Neurological Disorders and Stroke (NINDS),
and the National Institute of Dental and Craniofacial Research (NIDCR)
encourage investigator-initiated research grant applications on pathogenesis
and treatment of inflammatory myopathy. Responses to this program
announcement may include studies in appropriate animal models or preclinical
or clinical studies in patients with any form of inflammatory muscle disease.
Expiration Date: Friday, February 15, 2002 NOFO Number: RFA-DK-02-016 Release Date: Thursday, August 30, 2001 Notice Type: RFA
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),
the National Eye Institute (NEI) and the National Institute of Neurological
Disorders and Stroke (NINDS) seek applications to develop and validate
biomarkers for the microvascular complications of diabetes.
Prevention and treatment of long-term micro- and macrovascular complications
remain a critical problem in the management of type 1 and type 2 diabetes
mellitus. In the United States, diabetes is the leading cause of new
blindness in working-age adults, of new cases of end stage renal disease and
of non-traumatic lower leg amputations. Basic science advances in the coming
years are expected to lead to new therapies to prevent or treat the
development of nephropathy, retinopathy and neuropathy. Surrogate endpoints
for complications can be utilized in clinical trials to assess the efficacy
of these new therapies. In addition, such biomarkers may be useful for
predicting those patients who are at high risk for the development of
complications, and who may benefit from aggressive intervention.
Expiration Date: Saturday, March 16, 2002 NOFO Number: RFA-NS-02-008 Release Date: Tuesday, August 7, 2001 Notice Type: RFA
The National Institute of Neurological Disorders and Stroke (NINDS),
the National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK), and the Juvenile Diabetes Research Foundation (JDRF) solicit
applications for studies designed to elucidate the effects of acute and
recurrent episodes of hypoglycemia on glial and neuronal cells of the
developing and mature central nervous system. Recent therapeutic
strategies aimed at closely controlling elevated glucose levels in
diabetic individuals put them at risk for experiencing episodes of
hypoglycemia. Acute and recurrent hypoglycemia may cause transient or
persistent alteration of cognitive function, and can result in seizures
or coma. Recent studies of ischemia have provided information about
the effects of glucose deprivation coupled with hypoxia on cells of the
central nervous system. However, less is known about the effects of
reduced glycemic levels on CNS cell function and survival in a normoxic
environment.
Expiration Date: Thursday, November 22, 2001 NOFO Number: RFA-DK-01-032 Release Date: Friday, July 27, 2001 Notice Type: RFA
The National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK), the National Institute of Neurological Disorders and Stroke
(NINDS), the National Institute of Child Health and Human Development
(NICHD), the National Institute of Nursing Research (NINR) and the
Juvenile Diabetes Research Foundation International (JDRF) solicit
applications for clinical studies designed to enhance understanding and
prevention of hypoglycemia in patients with diabetes. Large clinical
trials have demonstrated the efficacy of intensified glucose control in
the prevention of the long-term complications of diabetes. However,
episodes of severe hypoglycemia may complicate intensified treatment
and are often a major obstacle to the achievement of euglycemia in many
patients. This RFA solicits clinical studies to 1) define and
characterize hypoglycemia in diabetic individuals and 2) develop new
approaches to prevent the development of hypoglycemia or to ameliorate
its effects in individuals with diabetes.
Expiration Date: Wednesday, November 21, 2001 NOFO Number: RFA-NS-02-004 Release Date: Friday, July 27, 2001 Notice Type: RFA
Deep brain stimulation (DBS) in the thalamus for the treatment of tremor was
approved by the FDA in 1997 following the pioneering work of Benabid and
colleagues in France. Subsequently it has been found that stimulation in the
subthalamic nucleus (STN) or globus pallidus (GPi) can relieve multiple
symptoms of Parkinson"s disease (PD). DBS has been successful in restoring
significant mobility to a large number of patients with advanced PD. During
the past year, GPi and STN stimulation underwent review at the FDA for
potential use to decrease symptoms of dyskinesia, tremor, postural
instability, and/or bradykinesia in individuals with advanced PD.