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-Purpose. This Funding Opportunity Announcement (FOA) issued by the Office of Research on Women's Health (ORWH) and co-sponsoring Institutes and Centers (ICs) of the National Institutes of Health (NIH) solicits investigator(s)-initiated applications that propose to examine the etiology, diagnosis, pathophysiology, and treatment of chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME/CFS) in diverse groups and across the lifespan. Applications that address gaps in the understanding of the environmental and biological risk factors, the determinants of heterogeneity among patient populations, and the common mechanisms influencing the multiple body systems that are affected in CFS are encouraged. The NIH is particularly interested in funding interdisciplinary research that will enhance our knowledge of the disease process and improve the diagnosis, treatment, and quality of life of all persons with CFS. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-07-263, which solicits applications under the R03 mechanism and PA-07-264, which solicits applications under the R21 mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

-Purpose. This Funding Opportunity Announcement (FOA) issued by the Office of Research on Women's Health (ORWH) and co-sponsoring Institutes and Centers (ICs) of the National Institutes of Health (NIH) solicits grant applications from organizations/institutions that propose to examine the etiology, diagnosis, pathophysiology, and treatment of chronic fatigue syndrome (CFS) in diverse groups and across the lifespan. Applications that address gaps in the understanding of the environmental and biological risk factors, the determinants of heterogeneity among patient populations, and the common mechanisms influencing the multiple body systems that are affected in CFS are encouraged. The NIH is interested in funding interdisciplinary research that will enhance our knowledge of the disease process and improve the diagnosis, treatment, and quality of life of all persons with CFS. -Mechanism of Support. This FOA will use the NIH Small Research Grant (R03) award mechanism and runs in parallel with FOAs of identical scientific scope, PA-07-265 and PA-07-264, which solicit applications under the Research Project Grant (R01) and the Exploratory/Developmental Grant (R21) award mechanisms respectively. -The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. 

-Purpose. The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. By pooling resources and expertise, the Blueprint takes advantage of economies of scale, confronts challenges too large for any single Institute or Center, and develops research tools and infrastructure that serve the entire neuroscience community. -This FOA is issued in complement with the NIH Notice NOT-EB-07-002. These FOAs intend to support modification, and enhancement of existing neuroimaging informatics tools and resources that are hosted or being considered for inclusion into the NIH Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC). Examples of such tools include image segmentation, image registration, image processing pipelines, statistical analysis packages, spatial alignment and normalization algorithms, and data format translators. Resources include well-characterized test datasets, data formats, and databases, among others. The proposed work shall significantly improve the interoperability and adoptability of neuroimaging informatics tools and resources and result in enhanced dissemination, adoption, and evolution of such tools and resources by the broader neuroimaging research community. This R03 announcement aims in particular to support NIH grantees with significant research in the subject domain area of developing neuroimaging informatics tools and resources but who are not currently eligible to apply for Administrative Revision (formerly “supplements”) under the NOT-EB-07-002. Applicants who are not currently funded by the NIH and who are associated with significant research in the subject domain area should also apply through this FOA.

Purpose. This announcement solicits applications for research project grants that will leverage and complement the ongoing technology development being pursued in the National Technology Centers for Networks and Pathways (TCNPs), a program of the NIH Roadmap for Medical Research. These collaborative projects should focus either on addressing a challenging biological problem using the technology developed in one or more of the TCNPs, or on the development of technology that will complement that which is being developed in the centers. Applicants may request support for their own work as well as supplemental support for components pursued in the participating TCNP. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Non-domestic (non-U.S.) Entity (Foreign Organization); Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Other(s): Eligible agencies of the Federal government.

-Purpose. This funding opportunity announcement (FOA) is for projects from individual-investigators or small groups to collaborate with the NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs). For a description of the NCBCs see http://www.bisti.nih.gov/ncbc/. The intention of the collaborating projects is to engage researchers across the nation in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. -Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the R21 grant mechanism and runs in parallel with an FOA of identical scientific scope, PAR-07-249 that solicits applications under the R01 mechanism. -This FOA is intended to support exploratory biomedical informatics and computational biology research-applications should be innovative, with high risk-high impact in new areas that are lacking preliminary data or development. Applications for R21 awards should describe projects distinct from those supported through the traditional R01 mechanism. For example, long-term projects, or projects designed to increase knowledge in a well-established area will not be considered for R21 awards. -Successful applications will be funded by the participating ICs.

-Purpose. This funding opportunity announcement (FOA) is for projects from individual-investigators or small groups to collaborate with the NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs). For a description of the NCBCs see http://www.bisti.nih.gov/ncbc/. The intention of the collaborating projects is to engage researchers across the nation in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. -Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, PAR-07-250 that solicits applications under the R21 mechanism, and which solicits innovative, high risk/high impact new areas that are lacking preliminary data or development. -Successful applications will be funded by the participating ICs.

-Purpose. This Funding Opportunity Announcement (FOA) solicits grant applications to develop research and methods to enhance the rate of membrane protein structure determination and to determine specific membrane protein structures.Innovative methods for expression, oligomerization, solubilization, stabilization, purification, characterization, crystallization, isotopic labeling, and structure determination of unique and biologically significant membrane proteins by x-ray diffraction, nuclear magnetic resonance (NMR), electron microscopic,mass spectrometry, and other biophysical techniques are encouraged.Projects that will lead in the near term to determining the structures of biologically important membrane proteins are also encouraged. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received.

Purpose. The National Institute of Neurological Disorders and Stroke (NINDS) encourages submission of investigator-initiated research grant applications to study mechanisms of transmission and dissemination of Transmissible Spongiform Encephalopathies (TSEs). Mechanism of Support. This funding opportunity will use the NIH Research Project Grant (R01) award mechanism, but will be run in parallel with two program announcements of identical scientific scope (PA-06-192 and PA-06-193) that will utilize the small research grant (R03) and exploratory/developmental grant (R21) mechanisms, respectively. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.

-Purpose. The National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Mental Health (NIMH), National Cancer Institute (NCI), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Tuberous Sclerosis Alliance invite research grant applications aimed at understanding or treating Tuberous Sclerosis Complex (TSC). -Mechanism of Support. This funding opportunity will use the NIH R01 research project grant mechanism, but will be run in parallel with two program announcements of identical scientific scope (PAS-06-205 and PAS-06-206) that will utilize the small research grant (R03) and exploratory/developmental grant (R21) mechanisms, respectively. -Funds Available and Anticipated Number of Awards. The participating organizations intend to commit a total of $2,000,000 to this Program Announcement with set-aside funds (PAS) and two other Program Announcements of identical scientific scope (see above) that utilize the R03 and R21 mechanisms. These funds are in addition to funds available for applications sent in response to these announcements that score within the paylines of the participating NIH Institutes. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

Purpose. The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Arthritis and Skin Diseases (NIAMS) encourage submission of investigator-initiated research grant applications to study restless legs syndrome (RLS) and periodic limb movement disorder. Mechanism of Support. The type of mechanism to be used is the Research Project (R01) mechanism. Funds Available and Anticipated Number of Awards. Specific funds are not set-aside for this funding opportunity announcement (FOA). Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.  Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.