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This funding opportunity announcement (FOA) solicits investigator-initiated research projects proposed by an applicant and collaborating scientist to conduct neuroscience research in a clearly defined area of mutual scientific interest.The project should consist of a thematic research plan that involves an efficacious collaborative effort among the participating investigators, each of whom will be conducting a portion of the total research project in his/her own laboratory.The applicant investigator must be from an eligible institution (see eligible institutions section). Collaborating institutions must document that the appropriate facilities, resources and research efforts will be committed for the investigators to accomplish the goals of the proposed research program.

Purpose. Participating Institutes and Centers (ICs) of the National Institutes of Health (NIH) invite applications for R01 awards to support Bioengineering Research Partnerships (BRPs) for basic, applied, and translational multi-disciplinary research that addresses important biological or medical research problems.In the context of this program, a partnership is a multi-disciplinary research team that applies an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior.The partnership must operate according to a clear leadership plan and include appropriate bioengineering or allied quantitative sciences in combination with biomedical and/or clinical components.BRP may propose, within a 40-page research plan, design-directed, developmental, discovery-driven, or hypothesis-driven research at universities, national laboratories, medical schools, large or small businesses, or other public and private entities or combinations of these entities, and will be evaluated against expanded review criteria.It is expected that a BRP will have a well-defined goal or deliverable that will be achieved in a 5-10 year timeframe based on objective milestones specified in the initial application.

The National Institute of Neurological Disorders and Stroke (NINDS) invite new and renewal grant applications for Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS).The intent of the SPOTRIAS is to support a collaboration of clinical researchers from different specialties whose collective efforts will lead to new approaches to early diagnosis and treatment of acute stroke patients.The goal of the SPOTRIAS will be to reduce the disability of and mortality in stroke patients by promoting rapid diagnosis and effective interventions. The support for SPOTRIAS is through an NIH specialized center grant (P50) mechanism.The maximum allowable direct cost per year for a SPOTRIAS will be $1,500,000. Required components of a SPOTRIAS (P50) grant application and grant include a minimum of three translational research projects, three or more cores, and a career development program. Required cores in a SPOTRIAS are a patient access core, tissue core, and a data management core.

-Purpose. The NIH is interested in promoting research and developments in computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research.As defined here, biomedical computing or biomedical information science and technology includes database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational and mathematical research including the development of structural, functional, integrative, and analytical models and simulations. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PAR-06-411, that solicits applications under the R21 mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

-Purpose.This Funding Opportunity Announcement (FOA) provides resources to facilitate exploratory research on psychosocial/behavioral treatments for autism, as well as innovative services research, including the development of instruments to evaluate the impact of interventions on core features of autism spectrum disorders, and comorbid symptomatology.It is intended to encourage research on: 1) the development and/or pilot testing of new or adapted interventions or instruments, 2) pilot testing interventions with preliminary efficacy data in larger clinical trials, or 3) innovative services research directions that require preliminary testing or development. -Mechanism of Support.This FOA will utilize the NIMH R34 grant mechanism -Funds Available and Anticipated Number of Awards.The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

-Purpose. This funding opportunity facilitates collaborative basic biomedical research between scientists supported by the National Institutes of Health (NIH) and investigators in developing countries. For behavioral and social sciences research, see the companion Funding Opportunity Announcement (FOA), Fogarty “International Research Collaboration – Behavioral, Social Sciences” Research Award program (FIRCA-BSS) (PAR-06-437).  -Mechanism of Support. This FOA will utilize the NIH R03 Small Grant mechanism, with additional eligibility, project period, and funding restrictions. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The anticipated number of awards is 30 to 40 per year.

-Purpose. The purpose of this initiative is to provide funding opportunities for the increasing pool of foreign basic and biomedical scientists, clinical investigators, nurses and other health professionals with state-of-the-art knowledge of research methods to advance critical issues in global health upon their return to their home low- or middle-income countries through basic and biomedical sciences research and technology development. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. -Funds Available and Anticipated Number of Awards. The total amount to be awarded is $300,000 and the anticipated number of awards is six.Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award may also vary; however, individual awards are limited to a maximum of $50,000 direct costs per year.The total amount awarded and the number of awards will depend upon the quality and costs of the applications received.

-Purpose. Biomedical research laboratories increasingly undertake a software development project to solve a problem of interest to that laboratory. These software packages sometimes become useful to a much broader community of users that can include translational and clinical researchers. The goal of this program announcement is to support the continued development, maintenance, testing and evaluation of existing software. The proposed work should apply best practices and proven methods for software design, construction, and implementation to extend the applicability of existing biomedical informatics/computational biology software to a broader biomedical research community. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award. -Funds Available and Anticipated Number of Awards Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon number, quality, duration, and costs of the applications received.

-Purpose. To encourage interdisciplinary, investigator-initiated translational research in the science of critical care. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

-Purpose. The goal of this funding opportunity announcement (FOA) is to invite Research Project Grant (R01) applications investigating the role of diet composition in energy balance, including studies in both animals and humans.Both short and longer-term studies are encouraged, ranging from basic studies investigating the impact of micro-or macronutrient composition on appetite, metabolism, and energy expenditure through clinical studies evaluating the efficacy of diets differing in micro- or macronutrient composition, absorption, dietary variety, or energy density for weight loss or weight maintenance. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.