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This initiative invites applications directed to the study of the pathogenesis, epidemiology, prevention, and treatment of repetitive motion disorders.

The National Institute of Nursing Research (NINR), National Institute on Aging (NIA), National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS), and the National Center for Medical Rehabilitation Research of the National Institute of Child Health and Human Development (NICHD) are interested in facilitating investigator-initiated research into nonpharmacological intervention strategies designed to deal with symptoms associated with cognitive impairment in adults. Several conditions can result in cognitive impairment, including Alzheimer"s disease, multi-infarct dementia, AIDS-related cognitive dysfunction, traumatic brain injury, stroke, and other neurological conditions such as Parkinson"s disease. The overall goals are to deter or delay symptoms requiring costly services or institutionalization and improve health-related quality of life for patients, caregivers, and families.

The purpose of this Request for Applications (RFA) is to expand the Rat Genome Project by soliciting applications for research projects to accomplish three objectives: 1) arraying and distributing existing rat cDNA libraries, 2) developing Expressed Sequence Tags (ESTs) from those libraries, and 3) mapping a subset of those ESTs. The overall goal of this effort is to construct a rat gene catalog and an EST map that will facilitate the mapping of genes in the rat and increase the value of the rat as a biomedical research model.

The National Institute of Neurological Disorders and Stroke (NINDS), National Eye Institute (NEI), National Institute of Child Health and Human Development (NICHD), and National Institute of Nursing Research (NINR) invite applications for support of research that will increase our knowledge of the mechanisms that underlie processes of injury and repair in the central nervous system (CNS), including optic nerve and other CNS tracts, and that will provide strategies for therapeutic intervention in spinal cord injury.

The National Institute of Mental Health (NIMH), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Drug Abuse (NIDA), and the National Institute of Child Health and Human Development (NICHD) invite research grant applications through this Program Announcement (PA) to support research focused on determining the pathogenic mechanisms involved in HIV-1 associated neurobehavioral and neurological dysfunction in adults and children. The objective of this cooperative effort is to foster investigations that will provide the foundation for the rapid development of therapeutic interventions to prevent and treat the effects of HIV-1 on the central nervous system (CNS). Applications ranging from basic research to clinical diagnosis and treatment studies are being solicited. Multidisciplinary research teams and collaborative alliances are encouraged but not required.

The National Institute on Aging (NIA), National Institute of Child Health and Human Development (NICHD, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Dental Research (NIDR), National Institute of General Medical Sciences (NIGMS), National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS), and National Institute of Nursing Research (NINR) are jointly sponsoring a new neuroscience predoctoral research training program. The aim of the program is to encourage and support broad training in the neurosciences by offering institutions a single comprehensive training grant. Support through the program is focused on the early years of training before full-time thesis research is started. Trainees are expected to be participants in a formal predoctoral curriculum offering broad and fundamental training in the neurosciences. For institutions that presently have multiple training grants with predoctoral trainees in the neurosciences, predoctoral training positions can now be consolidated into a single training grant jointly sponsored by the participating NIH Institutes. Applications will be also accepted from institutions without current training grant support . Existing training grants that have postdoctoral positions may continue, less any predoctoral positions moved to the consolidated application. Depending on the policies of the awarding NIH Institute, other training grants at the applicant institution may continue to support predoctoral trainees involved in thesis research (contact specific NIH Institute staff listed under INQUIRIES).

The National Institute of Neurological Disorders and Stroke (NINDS), invites applications for support of research that will increase our knowledge of the genetic, molecular, cellular, and physiological mechanisms of DNA injury and repair mechanisms in the nervous system after ischemic and traumatic injury, and in neurodegenerative disorders.

The National Institute of Neurological Disorders and Stroke announces the reissuance of a program announcement (PA) (originally published December 20, 1991) to notify the scientific community of its continued interest in the submission of research grant applications concerning neuronal ceroid lipofuscinosis.

It is generally agreed that the presence of HIV within the central nervous system (CNS) contributes to the development of neurobehavioral impairments and neurologic syndromes that occur in a subset of HIV-infected individuals. However, a direct link between the presence of virus and HIV-induced motor/cognitive impairments has yet to be elucidated. This program announcement solicits research applications to (1) identify effective ways to quantitate viral load within the CNS during life, (2) correlate the quantity of virus within the CNS to the onset and course of neurobehavioral and neurological changes, (3) identify specific biochemical or neurochemical alterations in neuronal function as a consequence of the presence of virus either directly or indirectly, and (4) identify and test drugs that prevent or reverse the neuronal dysfunction. Collaborations between neuroscientists and immunologists/virologists are encouraged but not required. Fellowships are also solicited through this program announcement to encourage a broader range of scientists to conduct research in this field.

The principal objective of this Program Announcement (PA) is to stimulate research on the basic mechanisms of neuronal cell death and injury as they relate to neurodegenerative disorders. The results of these investigations are expected to help in elucidating the pathogenesis of these diseases.