Sleep disturbances affect a wide range of age groups and practically
every segment of society is profoundly affected by the absence of
healthful patterns of sleep and wakefulness. It is now apparent that
sleep disorders, disturbances of sleep, and sleep deprivation are
major public health concerns. Recent estimates suggest that as many
as 40 million people may suffer from chronic or intermittent
disorders of sleep. Many of these people remain undiagnosed and
untreated, the consequences of which include reduced productivity,
lowered cognitive performance, increased likelihood of accidents,
higher risk of morbidity and mortality and decreased quality of life.
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COVID-19 Funding Notices | Approved Initiative Concepts | Research Opportunity Announcements
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Expiration Date: Tuesday, December 23, 1997 NOFO Number: PA-95-014 Release Date: Friday, December 23, 1994 Notice Type: PA
Expiration Date: Wednesday, February 15, 1995 NOFO Number: RFA-HD-95-005 Release Date: Friday, October 21, 1994 Notice Type: RFA
The Human Learning and Behavior Branch (HLB) of the Center for
Research for Mothers and Children (CRMC) of the National Institute of
Child Health and Human Development (NICHD) and the Developmental
Neurology Branch (DNB) of the Division of Convulsive, Developmental,
and Neuromuscular Disorders (DCDND) of the National Institute of
Neurological Disorders and Stroke (NINDS) invite research grant
applications to develop new knowledge in the areas of definition,
classification, epidemiology, prevention (and preventive strategies),
early intervention, etiology, diagnosis, and treatment of children
who display learning disabilities (LD) in component oral language
abilities (phonology, morphology, semantics, syntax, pragmatics),
reading (word attack skills, word recognition skills, reading
comprehension), written expression abilities (spelling, composition),
and mathematics (basic calculation skills, mathematical reasoning),
and combinations and relationships among them (e.g., combined
deficits in phonology, word attack skills, spelling behavior and
mathematics). An emphasis should also be placed on identifying the
distinctions and interrelationships (comorbidities) between well
defined types of learning disabilities and other well defined
disorders to include disorders of attention, oppositional/conduct
disorders, genetic disorders affecting learning (e.g., Fragile X
syndrome, Asperger"s syndrome, etc.). In addition, of significant
interest are longitudinal studies of treatment effectiveness with
children with LD who are well defined in terms of age, gender,
ethnicity, SES, primary LD, comorbid LD, severity of disability,
intensity and duration of any previous intervention(s), familial
and/or genetic findings, intellectual status, cognitive-linguistic
status, neuropsychological status, neurophysiological status,
educational status, and social/behavioral competencies.
Expiration Date: Saturday, November 19, 1994 NOFO Number: RFA-DK-94-023 Release Date: Friday, August 12, 1994 Notice Type: RFA
This request for applications (RFA) is designed to encourage research
grant applications focusing on mechanisms (primarily molecular and
genetic mechanisms) that underlie nutrient modulation of cellular
repair processes and maintenance of cellular integrity. Research
should be aimed at the normal processes involved in the effects of
specific nutrients or their metabolites on cellular, genetic, and
metabolic functions, as well as elucidation of defective mechanisms.
This initiative should offer unique opportunities afforded by the basic
sciences and new technologies (e.g., molecular biology, NMR, ESR, PET)
to enrich nutrition science. Nutrition science supported by the
National Institutes of Health (NIH) includes studies designed to assess
the consequences of food or nutrient intake, utilization in the intact
organism, and the metabolic and behavioral mechanisms involved.
Further support is needed for studies of nutrient variables at the
cellular and subcellular levels; elucidation of the metabolic functions
of nutrients in both animal models and humans; examination of
genetic-nutrient-environmental interactions; and ultimately, studies of
the role of diet in the maintenance of health, and the prevention and
treatment of disease.
Expiration Date: Tuesday, July 29, 1997 NOFO Number: PA-94-089 Release Date: Friday, July 29, 1994 Notice Type: PA
The National Institute on Aging (NIA), National Institute on Deafness
and Other Communication Disorders (NIDCD), National Institute of
Neurological Disorders and Stroke (NINDS), and National Aeronautics and
Space Administration (NASA) announce a continuing interest in
supporting ground-based studies of sensorimotor adaptation and
multisensory integration focusing on such functions as posture, gait,
and other limb and body spatially directed movements, in health, in
disease, and in special gravito-inertial environments.
Expiration Date: Tuesday, February 18, 1997 NOFO Number: PA-94-040 Release Date: Friday, February 18, 1994 Notice Type: PA
The National Institute of Neurological Disorders and Stroke (NINDS)
and the National Institute of Arthritis and Musculoskeletal and Skin
Diseases (NIAMS) encourage the submission of research grant
applications to investigate the potential for gene therapy in
Duchenne muscular dystrophy. Responses to this program announcement
may include studies in appropriate animal models of gene replacement
using viral vectors, myoblast transfer, or other means of dystrophin
enhancement.
Expiration Date: Tuesday, February 18, 1997 NOFO Number: PA-94-035 Release Date: Friday, February 18, 1994 Notice Type: PA
The National Institute of Neurological Disorders and Stroke (NINDS)
announces the reissuance of a program announcement (originally
published July 18, 1985) to notify the scientific community of
continuing NINDS interest in the submission of research grant
applications concerning neurogenetic disorders.
Expiration Date: Saturday, April 30, 1994 NOFO Number: RFA-HD-94-011 Release Date: Friday, February 4, 1994 Notice Type: RFA
The objective of the RFA is to stimulate research on the development
of effective technologies to assess the integrity and function of the
developing brain in the human fetus and newborns. The long-term goal
of this research is the identification of newborns with brain
dysfunction due to early, repetitive or chronic intrauterine central
nervous system (CNS) influences/insults, which may result in Sudden
Infant Death Syndrome (SIDS) and developmental disabilities including
cerebral palsy. Postnatally acquired and acute perinatal deficits
are not within the scope of this RFA. The National Institute of
Child Health and Human Development (NICHD) and the National Institute
of Neurological Disorders and Stroke (NINDS) invite applications for
studies in animals and/or humans that (1) elucidate the physiological
parameters that would serve as reliable markers of central nervous
system integrity/pathology; and (2) explore the development of
technologies/clinical tools that might identify infants who have, or
are at risk for, abnormal neurologic development or sudden death from
prenatal insults.
Expiration Date: Thursday, February 24, 1994 NOFO Number: RFA-DK-94-001 Release Date: Friday, October 1, 1993 Notice Type: RFA
The National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK) and the National Institute of Neurological Diseases and
Stroke, (NINDS) invite investigators to submit innovative research
applications for the development or improvement of techniques focused
on achieving successful human gene therapy for the treatment of
metabolic diseases. The ultimate goal of this program is to extend
the repertoire of diseases that can be successfully treated by gene
therapy. The diseases of interest include disorders of cellular
transport, disorders of lysosome metabolism, peroxisome metabolism,
amino acid and organic acid metabolism, carbohydrate metabolism,
purine and pyrimidine metabolism, metal metabolism, lipid metabolism,
and mucopolysaccharide metabolism. Many of these diseases require
the ability to deliver DNA to diverse tissue types. This program
will support regular research grants as well as limited feasibility
studies for new, highly innovative aspects of gene therapy.
Expiration Date: Wednesday, September 4, 1996 NOFO Number: PA-93-107 Release Date: Friday, September 3, 1993 Notice Type: PA
The National Cancer Institute (NCI) through the Diagnostic Imaging
Research Branch (DIRB) of the Radiation Research Program, the National
Library of Medicine (NLM), and the Division of Stroke and Trauma,
National Institute of Neurological Disorders and Stroke (NINDS) are
seeking grant applications that will address new medical imaging
database designs that focus on non-textual paradigms. The goal of
medical imaging databases is to provide a means for organizing a large
mass of heterogeneous, changing, pictorial, and symbolic data into a
structured environment that can be synthesized, classified, and
presented in an organized efficient manner to facilitate optimal
decision making in a health care environment. A properly organized
imaging database can compensate for human memory limitations and
provide an environment for improved patient care, research, and
education. Development of an effective and useful medical imaging
database must take place in an interdisciplinary environment, using the
medical knowledge from radiologists, radiation and medical oncologists,
neurologists and other specialties in collaboration with the database
research community and the imaging expertise of the computer and
Picture Archiving and Communications System (PACS) sciences.
Expiration Date: Saturday, November 20, 1993 NOFO Number: RFA-HD-94-006 Release Date: Friday, August 6, 1993 Notice Type: RFA
This Request for Applications (RFA) has been developed to encourage
research on the standards and methods for identifying and
characterizing optimal human fetal tissue for use in transplantation
therapy. Joint funding by the National Institute of Child Health and
Human Development (NICHD), the National Institute of Diabetes and
Digestive and Kidney Diseases (NIDDK), and the National Institute of
Neurological Disorders and Stroke (NINDS) reflects the extent of
interest in evaluating human fetal tissues and their biological
potentials. Attention should be given to proper collection,
processing, culturing and preserving these tissues to ensure highest
quality control. This research should consider addressing methods
for acquisition, handling, and processing, establishing morphologic
status, determining developmental age and viability, assessing
sterility and genetic normality, preserving by cryopreservation,
storing and establishing cell lines. President Clinton's directive
of January 22 ended the moratorium on Federal funding for use of
fetal tissue from induced abortions in human transplantation
research. Therefore, human fetal tissues studied under this
solicitation may be derived from spontaneous abortion, ectopic
pregnancy, or induced abortion.