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The National Institute of Nursing Research (NINR), National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Aging (NIA), National Institute on Deafness and Other Communication Disorders (NIDCD), and the National Center for Medical Rehabilitation Research (NCMRR) of the National Institute of Child Health and Human Development (NICHD) seek research applications that address effective nonpharmacological approaches to managing the initial events and subsequent symptoms of a stroke. This research would focus on reducing the impairments, preventing secondary complications, and improving the functional independence and the quality of life for the individual following a stroke.

The objective of this initiative is to establish collaborative teams of closely interacting investigators with diverse, complementary areas of expertise to elucidate the molecular genetic mechanisms of thrombosis in the arterial and cerebral vasculature. The overall goal is to stimulate innovative multidisciplinary research to expedite progress in understanding the pathogenesis of thrombosis in both the arterial and cerebral vasculature and to facilitate the application of new findings for better detection, prevention, and treatment.

Research at the borders of disciplines and from fresh perspectives often produces surprising and exciting results. Increasingly, teams of scientists from diverse disciplines converge on a common research questions. Individuals who can independently bridge different disciplines, as well as those who are able to function as leading members of multi-disciplinary research teams are playing ever more valuable roles at the forefront of biomedicine. The purpose of the Mentored Quantitative Research Career Development Award (K25) is to engender and foster such activities by supporting the career development of investigators with quantitative scientific and engineering backgrounds outside of biology or medicine who have made a commitment to focus their research endeavors on behavioral and biomedical research (basic or clinical). This mechanism is aimed at research-oriented scientists with experience at the level of junior faculty (e.g., early to mid-levels of assistant professor or research assistant professor ranks). This award provides support for a period of supervised study and research for professionals with such backgrounds who have the potential to integrate their expertise with biomedicine and develop into productive investigators.

The purpose of this request for applications (RFA) is to establish facilities for large-scale mutagenesis and phenotyping of nervous system functions and complex behaviors in the laboratory mouse. Neuroscience-focused mutagenesis and phenotyping facilities established by this RFA are expected to serve as a national resource by producing a bank of mouse strains that harbor a wide range of mutations affecting murine nervous system function and behavior. Data and biomaterials produced in projects supported under this RFA will be made widely available to the scientific community.

The sponsoring organizations are jointly offering this Program Announcement (PA). Although this PA applies to several agencies, it will be administered according to National Institutes of Health (NIH) policies and procedures. This PA is one of the steps the NIH is taking to develop an on-going, multi-agency, comprehensive program in research ethics. Other steps include the "Short-Term Courses in Research Ethics" (T15), PA-99-051 (http://www.nih.gov/grants/guide/pa-files/PA-99-051.html), and the "Mentored Scientist Development Award in Research Ethics" (K01), PA-99-050 (http://www.nih.gov/grants/guide/pa-files/PA-99-050.html), both published in the NIH Guide for Grants and Contracts, January 22, 1999.

The purpose of this five-year research grant program is to enhance our understanding of the etiology, extent, services, treatment, management, and prevention of child neglect. This Request for Applications (RFA) is intended to stimulate the development of programs of child neglect research at institutions that currently have strong research programs in related areas (e.g., child development, injury prevention, developmental neurobiology, child abuse, substance abuse, population research, craniofacial and dental public health, health services) but are not engaged in extensive research focusing on child neglect. A second goal of this RFA is to bring the expertise of researchers from the child health, education, and juvenile justice fields into the child neglect research field and to promote their collaborations with each other and with child neglect and child abuse researchers.

The purpose of this RFA is to support the development of technologies that will facilitate the generation of a complete set of full-length human cDNAs as well as other mammalian cDNAs. Current methods of cDNA clone and library production favor shorter, more heavily represented genes. In addition, although current methodology for isolating mRNA for use in cDNA construction works well with cell lines, reliable methodologies for extraction of high quality mRNA from tissues remains a challenge. Use of human tissues may be necessary to achieve the goal of a complete set of human cDNA clones. Finally, reliable, high-throughput methods to determine whether clones contain a copy of the full transcript, the full coding region, or a partial transcript are needed. This RFA is intended to support innovative research projects aimed at solving one or more of the problems currently associated with the production of a complete set of full-length human cDNA clones and full-length cDNA clones from other mammals.

In response to the recommendations of the Rat Genome Advisory Committee and the Report of the NIH Model Organism Database Workshop (http://www.nhlbi.nih.gov/) the NIH proposes to establish a Rat Genome Database (RGDB). The objective of this RFA is to establish a database that will collect, consolidate, and integrate data generated from ongoing rat genetic, genomic, and related research efforts, and to make these data widely available to the scientific community.

The National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS) are soliciting applications for research that will make use of neuroimaging techniques to monitor structural, functional, and metabolic correlates of human immunodeficiency virus/central nervous system (HIV/CNS) disease. Advanced structural and functional neuroimaging techniques are providing new opportunities to identify clinically significant abnormalities and relate them to neurological and neuropsychological dysfunction. As new and improved therapeutic interventions are becoming available for controlling HIV disease progression, the importance of non-invasive monitoring of HIV/CNS disease is necessary for treatment response monitoring.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of Environmental Health Sciences (NIEHS), the National Institute on Deafness and other Communication Disorders (NIDCD), the National Eye Institute (NEI), the National Heart, Lung and Blood Institute (NHLBI), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), and the Office of Research on Women"s Health invite applications for research on the genetic bases and molecular pathways of target organ damage in rheumatic and autoimmune diseases. The applications may be for individual research projects (R01), for a group of independent research projects that use the interactive research project grant (IRPG) mechanism, or for exploratory/developmental grants (R21). The research should be specifically targeted towards identification and evaluation of cellular and molecular pathways involved in organ damage and on the genetic basis for target organ involvement in autoimmunity. This Request for Applications (RFA) solicits basic, translational and clinical research projects, but not epidemiological or clinical treatment projects.