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The objective of this Request for Applications (RFA) is to stimulate research on the relative roles of environmental, endogenous neurochemical and modifying genetic factors in the cause of Parkinson's disease. Recent evidence from twin studies has shown that genetics plays less of a role and environmental factors a potentially greater role than previously thought in the development of late-onset Parkinson's disease (PD). In response to this finding, the National Institute of Environmental Health Sciences (NIEHS) and National Institute of Neurological Disorders and Stroke (NINDS) invites scientists to submit research grant applications for research aimed at elucidating the role of the environment in the development of Parkinson's disease. The results of these investigations will contribute to clarifying the part environmental factors play in the etiology of this disease.

The National Institute of Neurological Disorders and Stroke(NINDS),in collaboration with the National Center for Research Resources(NCRR)invites applications for Specialized Neuroscience Research Programs(SNRP)at Minority Institutions Awards. The purpose of this Request for Applications(RFA)is to augment and strengthen the research capabilities of faculty, students, and fellows at minority institutions by supporting the development of new, and/or the enhancement of ongoing, basic and clinical neuroscience research projects and programs.

The purpose of this Request for Applications (RFA) is to stimulate the career development of physician-scientists engaged in research on the relative roles of environmental, endogenous neurochemical, and modifying genetic factors in the cause of Parkinson's Disease (PD). Recent evidence from twin studies has shown that genetics plays less of a role and environmental factors a potentially greater role than previously thought in the development of late-onset PD. In response to this finding, the National Institute of Environmental Health Sciences (NIEHS) and the National Institute of Neurological Disorders and Stroke (NINDS) have issued an RFA (ES-00-002) for research project grants for research aimed at elucidating the role of the environment in the development of PD. The results of these immediate investigations will contribute to clarifying the part environmental factors play in the etiology of this disease. It is recognized, however, that long-term progress in research in this area is dependent on developing a cadre of scientists who can carry the state of knowledge to the next level. This is especially true of physician scientists who can relate fundamental and laboratory findings concerning the role of the environment in PD to the human disease state. This RFA for career development applications addresses that priority goal.

The goal of this initiative is to promote the performance of research and transfer of findings that will benefit the health of women. The Programs will accomplish this by bridging advanced training with research independence, as well as bridging scientific disciplines or areas of interest. This will increase the number and skills of investigators at awardee institutions through a mentored research experience leading to an independent scientific career addressing women"s health concerns.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Eye Institute (NEI), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Neurological Disorders and Stroke (NINDS), and National Heart, Lung, and Blood Institute invite investigator- initiated research grant applications to study the role of growth factors in the etiology and pathogenesis of the micro- and macrovascular complications of diabetes. While several growth factors are already being tested in clinical trials for the treatment and/or prevention of diabetic microvascular disease, a systemic examination of the pathophysiologic role of growth factors in diabetic complications is lacking. This PA, with a $2 million NIDDK annual set-aside, is intended to stimulate the application of new molecular technologies to this area. An understanding of the tissue and cell specific expression of growth factors in the eye, kidney, mouth, nerves and vessels, and of the molecular action of these growth factors in the pathophysiology of complications will lead to improved and more specific therapies.

The National Institute of Neurological Disorders and Stroke (NINDS), a component of the National Institutes of Health (NIH), invites applications for Specialized Neuroscience Research Programs (SNRP) on Health Disparity awards. The purpose of this Request for Applications (RFA) is to augment and strengthen the research capabilities of faculty, students, and fellows at minority institutions by supporting the development of new, and/or the enhancement of ongoing basic and clinical neuro-AIDS related research projects and programs. These awards will be made to support individuals at minority institutions who collaborate with one or more established NIH supported investigators at research intensive organizations. The collaborative research program"s focus should be on prevention of neurological complications of HIV infection.

The purpose of this initiative is to encourage and support investigator-initiated, Neuroinformatics research that will lead to new digital and electronic tools for all domains of neuroscience research reflecting normal and diseased states across the life span. Neuroinformatics combines neuroscience and informatics research to develop and apply advanced tools and approaches essential for a major advancement in understanding the structure and function of the brain. Research in Informatics includes databases, graphical interfaces, querying approaches, information retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, synthesis, and tools for electronic collaboration. In computational research, the focus is on development of structural, functional, integrative, and analytical models and simulations. The advanced information technologies resulting from this research will be put to wide use by the Neuroscience community. Therefore, the approaches and technologies solicited under this announcement should be generalizable, scalable, extensible, interoperable and use sophisticated powerful computational resources and integrated with significant neuroscience research at and across all levels of analysis of brain function.

The five sponsoring Institutes invite applications in response to this Program Announcement (PA) for the career development for investigators who have made a commitment to focus their research endeavors on child abuse and neglect through research career enhancement in order to conduct high quality, multi- disciplinary, clinically-relevant research on basic biological, behavioral, and social aspects of child and adolescent abuse and neglect. While the focus of the career development program is on child abuse and neglect in human populations, the award may include complementary, appropriate laboratory and animal research related to the child abuse and neglect research proposed in the application. This initiative will be supported through the following NIH career award mechanisms: K01, K02, K08, K23, and K24 (see: http://www.nih.gov/training/careerdevelopmentawards.htm). Prospective applicants should follow the specific provisions and guidelines outlined in each program announcement. It is equally important to note that each Institute has different provisions for each of these career award mechanisms (see MECHANISMS OF SUPPORT)

The National Institute on Aging (NIA), in collaboration with the National Institute of Child Health and Human Development (NICHD), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Eye Institute (NEI), and the National Institute of Neurological Disorders and Stroke (NINDS), invites grant applications in the area of age-related changes in multiple sensory systems. A major goal of aging research is directed toward the public health issue of maintaining functional independence of the elderly individual. Aside from specific diseases, sensory declines represent a broad category of normal age-related changes that can lead to diminished quality of life for the elderly individual, loss of independence, and increased costs for society as a whole. Although declines in single sensory systems have been studied, there is less information about the effects of concurrent changes in multiple systems, at either the population or basic science level. The purpose of this program announcement is to stimulate research investigating: (1) the prevalence and extent of concurrent declines in multiple sensory systems in the elderly, (2) the effects such declines might have on the functional capacities of the individual, and (3) the underlying mechanisms responsible for commonalities in age-related sensory changes at central nervous system, cellular, molecular or genetic levels.

The National Heart, Lung, and Blood Institute (NHLBI), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of General Medical Sciences (NIGMS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Child Health and Human Development (NICHD), National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Nursing Research (NINR), and Office of Research on Women"s Health (ORWH) invite research grant applications to conduct studies on microbial biofilms leading to improved strategies and technologies to diagnose, prevent and treat biofilm-associated infectious diseases.