The Independent Scientist Award (K02) provides up to five years of salary
support for newly independent scientists who can demonstrate the need for a
period of intensive research focus as a means of enhancing their research
careers. This award is intended to foster the development of outstanding
scientists and enable them to expand their potential to make significant
contributions to their field of research.
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Expiration Date: Saturday, July 1, 2006 NOFO Number: PA-00-020 Release Date: Thursday, December 2, 1999 Notice Type: PA
Expiration Date: Monday, December 2, 2002 NOFO Number: PA-00-018 Release Date: Thursday, December 2, 1999 Notice Type: PA
This Program Announcement (PA), issued as an initiative of the trans-NIH
Bioengineering Consortium (BECON), invites grant applications for Small
Business Innovation Research (SBIR) projects on nanotechnologies useful to
biomedicine. Nanotechnology is defined as the creation of functional
materials, devices and systems through control of matter at the scale of 1 to
100 nanometers, and the exploitation of novel properties and phenomena at the
same scale. Nanotechnology is emerging as a field critical for enabling
essential breakthroughs that may have tremendous potential for affecting
biomedicine. Moreover, nanotechnologies developed in the next several years
may well form the foundation of significant commercial platforms.
Expiration Date: Saturday, November 30, 2002 NOFO Number: PAS-00-006 Release Date: Tuesday, November 30, 1999 Notice Type: PAS
Participating Institutes and Centers (ICs) of the National Institutes of Health
(NIH) invite applications for R01 awards to support Bioengineering Research
Partnerships (BRPs) for basic bioengineering research addressing important
biological or medical research problems. A BRP is a multidisciplinary research
team applying an integrative, systems approach to develop knowledge and/or
methods to prevent, detect, diagnose, and treat disease and understand health
and behavior. The partnership must include bioengineering expertise in
combination with basic and/or clinical investigators. A BRP may propose design-
directed or hypotheses-driven research in universities, national laboratories,
medical schools, private industry and other public and private entities.
Expiration Date: Tuesday, October 10, 2000 NOFO Number: RFA-AI-00-005 Release Date: Wednesday, November 24, 1999 Notice Type: RFA
The National Institute of Allergy and Infectious Diseases (NIAID), the
National Institute on Aging (NIA), the National Institute of Arthritis and
Musculoskeletal and Skin Diseases (NIAMS), the National Institute of
Diabetes and Digestive and Kidney Diseases (NIDDK), the National Heart,
Lung and Blood Institute (NHLBI), the National Institute of Neurological
Disorders and Stroke (NINDS), and the Office of Research on Womens Health
(ORWH) of the National Institutes of Health (NIH) invite investigator-
initiated research applications for mechanistic studies in clinical trials
of immunomodulatory interventions for immune system mediated diseases,
including, but not limited to, asthma and allergy, graft failure in solid
organ, tissue, cell and stem cell transplantation, and autoimmune diseases.
Specifically, this Request for Applications (RFA) is a continuation and
modification of RFA AI-98-006. It focuses on the inclusion of patients and
utilization of patient samples for the evaluation of immunologic and other
relevant parameters to facilitate the study and definition of immunological
mechanisms underlying the intervention, the mechanisms of disease
pathogenesis, surrogate/biomarkers markers of disease activity and
therapeutic effect, and mechanisms of human immunologic function. The
parent or core clinical trial must have independent financial support and
will NOT receive support under this RFA. Proposed mechanistic studies
associated with clinical trials supported by industry are particularly
encouraged but clinical trials supported by any source, public or private,
are eligible.
Expiration Date: Thursday, March 30, 2000 NOFO Number: RFA-MH-00-002 Release Date: Monday, November 22, 1999 Notice Type: RFA
The purpose of this Request for Applications (RFA) is to solicit feasibility
studies for profiling gene expression patterns in the mammalian nervous
system. Exploratory research projects supported under this RFA will utilize
neural tissue-specific cDNA reagents and state-of-the-art microarray
technologies, in order to quantify in a highly parallel way expression
profiles of genes in mammalian neural tissue. The creation of collaborative
teams is encouraged, in which scientists with expertise in neuroscience
research, genomics, and bioinformatics work to apply innovative approaches
for analyzing microarray data.
Expiration Date: Tuesday, October 8, 2002 NOFO Number: PA-00-005 Release Date: Friday, October 8, 1999 Notice Type: PA
The purpose of the Midcareer Investigator Award in Patient-Oriented Research
(K24) is to provide support for clinicians to allow them protected time to
devote to patient-oriented research and to act as mentors for beginning
clinical investigators. The target candidates are outstanding clinical
scientists who are actively engaged in patient-oriented research. Candidates
are generally within 15 years of their specialty training. Candidates must be
able to demonstrate the need for a period of intensive research focus as a
means of enhancing their clinical research careers and must be committed to
mentoring the next generation of patient-oriented researchers. The award is
intended to further both the research and mentoring endeavors of outstanding
patient-oriented investigators, to enable them to expand their potential for
significant contributions to their field, and to act as mentors for beginning
clinician researchers.
Expiration Date: Saturday, July 1, 2006 NOFO Number: PA-00-003 Release Date: Friday, October 8, 1999 Notice Type: PA
The purpose of the Mentored Clinical Scientist Development Award (K08) is to
support the development of outstanding clinician research scientists. This
mechanism provides specialized study for individuals with a health
professional doctoral degree committed to a career in laboratory or field-
based research. Candidates must have the potential to develop into
independent investigators. The K08 supports a three, four, or five year
period of supervised research experience that may integrate didactic studies
with laboratory or clinically-based research. The proposed research must have
intrinsic research importance as well as serving as a suitable vehicle for
learning the methodology, theories, and conceptualizations necessary for a
well trained independent researcher.
Expiration Date: Saturday, October 8, 2005 NOFO Number: PA-00-004 Release Date: Friday, October 8, 1999 Notice Type: PA
The purpose of the Mentored Patient-oriented Research Career Development Award
(K23) is to support the career development of investigators who have made a
commitment to focus their research endeavors on patient-oriented research.
This mechanism provides support for three to five years of supervised study
and research for clinically trained professionals who have the potential to
develop into productive, clinical investigators focussing on patient-oriented
research. Clinically trained professionals or individuals with a clinical
degree who are interested in further career development in biomedical research
that is not patient-oriented, should refer to the Mentored Clinical Scientist
Career Development (K08) Award (see
http://grants.nih.gov/training/careerdevelopmentawards.htm on the NIH website
for details).
Expiration Date: Thursday, February 17, 2000 NOFO Number: RFA-NS-99-008 Release Date: Monday, September 27, 1999 Notice Type: RFA
Traumatic spinal cord injury currently affects approximately 250,000
Americans. Many functional changes can result, including the loss of
voluntary movements below the level of the spinal lesion. Research from a
variety of animal models has shown that various spinal circuits, with
appropriate ascending and descending input, are critical for coordinated
voluntary and reflex movements including not only standing and walking,
but also control of bladder, bowel, and sexual functions. Since many spinal
cord injuries leave much of the spinal cord intact, reactivation of the
"spinal pattern generators" to control at least some of these lost functions
seems possible. Fundamental research, in mammalian systems, on the anatomy
and physiology of intrinsic spinal circuits that are involved in volitional
movements will play a key role in unlocking the potential to restore
function after injury.
Expiration Date: Thursday, February 17, 2000 NOFO Number: RFA-NS-99-006 Release Date: Monday, September 27, 1999 Notice Type: RFA
In response to the resurgence of interest in the application of neurosurgical
approaches to the treatment of movement disorders and especially Parkinson's
disease, the National Institute of Neurological Disorders and Stroke (NINDS)
and the National Institute on Aging (NIA) invite qualified investigators to
submit grant applications for a broad range of studies aimed at improving the
use of deep brain stimulation as a therapy. The purpose of this Request for
Applications (RFA) is to encourage additional basic and clinical studies into
the mechanisms of a potentially reversible, adjustable and long term
electrical treatment of neurological disorders. It is expected that this
research will produce a greater understanding of the circuitry involved in
movement and related disorders, the development of improved electrodes for use
in deep brain stimulation, and improved treatment.