The purpose of this initiative is to encourage and support investigator-
initiated research on neuroscience informatics (neuroinformatics). This
research will lead to the development of new web based databases, analytical
tools, and knowledge management systems to foster sharing of data for all
domains of neuroscience research. This program combines neuroscience and
informatics (neuroinformatics) research to develop and apply advanced tools and
approaches essential for efficient understanding of the structure, function and
development in health and disorders of the nervous system, from the genetic to
whole systems level. Research in informatics includes databases, graphical
interfaces, querying approaches, information retrieval, data visualization and
manipulation, and data integration through the development of integrated
analytical tools, synthesis, and tools for electronic collaboration. In order
for these advanced information technologies to be put to wide use by the
neuroscience community, they should be generalizable, scalable, extensible, and
interoperable, and be developed in concert with significant neuroscience
research.
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COVID-19 Funding Notices | Approved Initiative Concepts | Research Opportunity Announcements
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Expiration Date: Friday, September 23, 2005 NOFO Number: PAR-03-035 Release Date: Tuesday, December 3, 2002 Notice Type: PAR
Expiration Date: Saturday, February 22, 2003 NOFO Number: RFA-DK-03-012 Release Date: Tuesday, November 26, 2002 Notice Type: RFA
The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of
the National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK), in collaboration with the National Institute of Neurological
Disorders and Stroke (NINDS) and the National Institute of Child Health
and Human Development (NICHD), invites cooperative agreement
applications for two Clinical Coordinating Centers and a Data
Coordinating Center to conduct a prospective epidemiological study of
children with chronic kidney disease. The primary goals of this study
are to determine the risk factors for decline in renal function; the
incidence of, and risk factors for, impaired neurocognitive development
and function; the prevalence of risk factors for cardiovascular
disease; and the long-term effects of growth failure and its treatment.
Expiration Date: Sunday, August 24, 2003 NOFO Number: PAR-03-032 Release Date: Wednesday, November 20, 2002 Notice Type: PAR
Participating Institutes and Centers (ICs) of the National Institutes of
Health (NIH) invite applications for R01 awards to support Bioengineering
Research Partnerships (BRPs) for basic and applied multi-disciplinary research
that addresses important biological or medical research problems. A BRP is a
multi-disciplinary research team applying an integrative, systems approach to
develop knowledge and/or methods to prevent, detect, diagnose, or treat
disease or to understand health and behavior. The partnership must include
appropriate bioengineering or allied quantitative sciences in combination with
biomedical and/or clinical investigators. A BRP may propose design-directed,
developmental, discovery-driven, or hypothesis-driven research at
universities, national laboratories, medical schools, large or small
businesses, or other public and private entities or combinations of these
entities.
On October 11, 2001, NIH issued a related program announcement (PA) PA-02-011
for Bioengineering Research Grants (BRGs). The BRGs differ from the BRPs in
that the BRG research will be performed in a single laboratory or by a small
number of investigators.
Expiration Date: Tuesday, November 1, 2005 NOFO Number: PA-03-031 Release Date: Monday, November 18, 2002 Notice Type: PA
The National Institute of Biomedical Imaging and Bioengineering (NIBIB), the
National Heart, Lung, and Blood Institute (NHLBI), the National Institute of
Environmental Health Sciences (NIEHS), the National Center for Research
Resources (NCRR), the National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK), and the National Institute of Neurological Disorders and
Stroke (NINDS) invite grant applications for Small Business Innovation
Research (SBIR) and Small Business Technology Transfer (STTR) awards to
support research and development of small animal imaging devices and methods
that can be applied broadly to research on diverse biological or disease
processes. A similar Request for Applications (RFA) for small animal imaging
research and development to be supported by individual Research Project Grant
(R01) awards can be found at
(http://grants.nih.gov/grants/guide/rfa-files/RFA-EB-03-002.html).
The primary focus of this Program Announcement (PA) is research and
development related to devices, methods, and imaging agents for the
investigation of biological and disease processes in small animals. The
integration of systems and methods with complementary imaging and/or
spectroscopy modalities is also included as appropriate to provide anatomic,
physiologic, metabolic, and molecular-level information in small animal
models of disease.
The motivation for this PA is that recent discoveries in genomics and
molecular and cell biology have led to the development and wide use of small
animal models of human disease. One of the limitations with the use of these
models is the need to sacrifice large numbers of animals for ex vivo tissue
and molecular analysis. Imaging instrumentation and methods that permit
imaging on the scale of small animals offer an opportunity to address this
problem by enabling noninvasive investigations of biological processes in
vivo. This capability provides the potential for longitudinal studies in the
same animal. The coupling of animal models of human disease with advances in
imaging technology presents an extraordinary opportunity for biomedical
imaging to play an important role in the early detection, diagnosis, and
treatment of disease. Several dedicated small animal imaging systems have
been developed and a few commercialized, although technological hurdles still
exist that limit the realization of the full potential of small animal
imaging for biomedical research and drug development. Progress is needed to
improve throughput, sensitivity, and spatial and temporal resolution of small
animal imaging devices, to provide quantitative information through improved
reconstruction methods that incorporate models of physical effects, and to
provide improved methods for system validation. System optimization
incorporating the design of molecular probes that serve as links to
particular biological processes in vivo is also a focus. Further improvements
in system design, image processing and analysis software, and data sharing
technology, coupled with improvements and innovations in animal handling
techniques during imaging, are needed to make small animal imaging technology
more accessible to molecular biologists and pharmaceutical scientists
desiring to use animal models as tools for biomedical research and drug
discovery and development.
Expiration Date: Wednesday, March 12, 2003 NOFO Number: RFA-TW-03-007 Release Date: Thursday, November 7, 2002 Notice Type: RFA
This Request for Applications (RFA) solicits applications to plan and develop
collaborative research and capacity building projects on brain disorders
throughout life relevant to low- and middle-income nations. Applicants are
expected to develop innovative, collaborative research programs that would
contribute to the long-term goal of building sustainable research capacity in
neurological/neurodevelopmental (including sensory, motor, cognitive and
behavioral) impairment throughout life.
This RFA is joined by the following Institutes and Centers: NIH sponsors
include the Fogarty International Center (FIC), National Eye Institute (NEI),
National Institute on Aging (NIA), National Institute on Alcohol Abuse and
Alcoholism (NIAAA), National Institute of Child Health and Human Development
(NICHD), National Institute on Drug Abuse (NIDA), National Institute of
Environmental Health Sciences (NIEHS), National Institute of Mental Health
(NIMH), National Institute of Neurological Disorders and Stroke (NINDS) and
the Office of Dietary Supplements (ODS); for Canada, the Canadian Institutes
of Health Research (CIHR) and for Mexico, the Consejo Nacional de Ciencia y
Tecnologa (Conacyt). These sponsoring organizations seek domestic and
international collaborative applications which address brain disorders in the
developing world and which build research capacity of low- to middle-income
countries to address brain disorders within their country or region.
This first phase of the "Brain Disorders in The Developing World: Research
Across the Lifespan" initiative, beginning in fiscal year 2003 (FY03), will
consist of two-year planning/development grants using the R21 grant
mechanism. The R21 grant will provide support to initiate preliminary
studies and to organize, plan, prepare, and assemble an application for a
more comprehensive R01 grant involving collaboration between high-income and
low- to middle-income country investigators and which incorporates both
research and capacity building.
The main goals of the R21 applications should be to assess needs, develop
collaborations and needed resources, show feasibility and generate
preliminary data for the collaborative research to be proposed in a follow-up
R01 submission. The applicants should propose specific milestones and a
timeline to meet these goals. During the R21 award period, the applicant
should:
o further define the type and area of research to be developed;
o develop and solidify collaborative relationships and understandings with
the partners in the developed and developing countries involved;
o assess current resources and needs, such as and including the need for an
institutional review board (IRB) for studies involving human subjects;
o develop and initiate a plan to address these needs to enable the proposed
research and capacity building to be successfully carried out;
o identify the training and other capacity-building opportunities to be
incorporated into the research application in the context of the proposed
research;
o initiate cross-training of collaborators where necessary for the proposed
research; and
o conduct pilot studies and generate preliminary data;
Projects should: 1) Involve a partnership between high-income and low-to
middle-income country individuals or research teams; 2) lead to pursuit of
basic, epidemiological, clinical, prevention, intervention or health services
research in the area of brain disorders of relevance to low- to middle-income
countries; and 3) build capacity as necessary in the proposed research area
to enable further research to take place.
An RFA for the second competitive phase of the "Brain Disorders in The
Developing World: Research Across the Lifespan" initiative is currently
planned to be issued in fiscal year 2005 (FY05), subject to availability of
funds. That RFA is planned to provide support for collaborative research and
capacity building to high-income and low- to middle-income country partners
through the R01 mechanism. The second phase RFA competition, as currently
planned, will not be limited to the R21 grantees under this competition, but
will be open to all eligible applicants.
Expiration Date: Wednesday, February 19, 2003 NOFO Number: RFA-TW-03-006 Release Date: Monday, November 4, 2002 Notice Type: RFA
This RFA is intended to promote productive re-entry of NIH-trained foreign
investigators into their home countries as part of a broader program to
enhance the scientific research infrastructure in developing countries, to
stimulate research on a wide variety of high priority health-related issues
in these countries, and to advance NIH efforts to address health issues of
global import.
The specific goal of this initiative is to provide funding opportunities for
the increasing pool of foreign biomedical and behavioral scientists, clinical
investigators, nurses, and other health professionals with state-of-the-art
knowledge of research methods to advance critical issues in global health
upon their return to their home countries. After their term of research
training, developing country participants supported by this RFA are expected
to continue independent and productive scientific careers, including expert
training and consultation and/or research of biomedical issues within their
home institutions.
Expiration Date: Tuesday, February 25, 2003 NOFO Number: RFA-AR-03-002 Release Date: Thursday, October 31, 2002 Notice Type: RFA
The National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS), the National Institute of Neurological Disorders and Stroke (NINDS)
and the National Institute of Child Health and Human Development (NICHD) seek
developmental planning grant applications for the establishment of an
infrastructure for eventual Muscular Dystrophy Cooperative Research Centers
(MDCRCs). This initiative supports the planning of new or expansion of
existing resources for future competitive MDCRCs. These planning grants will
enable applicants to effectively organize and integrate multidisciplinary
research capacities and core resources to enhance collaborations of basic,
clinical, and behavioral science in muscular dystrophy research and to
promote cross-disciplinary research training.
Participation in this RFA will not itself be a factor in the review of any
Center application. Investigators may respond to current (e.g., RFA AR03-
001) or future solicitations for center grant applications without first
having participated in this developmental planning initiative.
Investigators interested in applying for support of muscular dystrophy
research using mechanisms other than centers or this developmental planning
initiative should see NIH PAS01-041, "Therapeutic and Pathogenic Approaches
for the Muscular Dystrophies"
(http://www.niams.nih.gov/rtac/funding/grants/pa/pas_01_041.pdf).
Expiration Date: Tuesday, February 15, 2005 NOFO Number: PAR-03-007 Release Date: Thursday, October 10, 2002 Notice Type: PAR
This PA solicits applications to develop new genetic-based methods and
technologies for the purpose of mapping functional neuronal circuits and
synaptic changes in the mammalian nervous system. Emerging genetic and
transgenic technologies can be used to single out functionally related cells
or neuronal populations for analysis or intervention. This PA would support
the development of genetic-based tools to map neuronal interconnectivity, to
monitor functional changes, or to drive functional changes within neuronal
circuits as the first step in an effort by the NIH to create integrated
genomic and functional connectivity maps of the mammalian nervous system.
Other corollary efforts needed to generate integrated connectivity maps such
as improved neuroinformatics and the development of a large consortia of
investigators, however, are outside the scope of this program announcement.
Wide distribution to the scientific community of the methods and resulting
resources developed under this program is essential for the eventual goal of
creating large-scale functional connectivity maps of the mammalian nervous
system. The unrestricted distribution of methods and resources developed
under this program will also facilitate the rapid transfer of technology for
the development of diagnostic tools and treatment interventions for brain
disease.
Expiration Date: Wednesday, November 2, 2005 NOFO Number: PAR-03-004 Release Date: Monday, October 7, 2002 Notice Type: PAR
In response to continuing research progress and opportunity, and in
recognition of continuing Congressional interest to intensify and to
expand basic and clinical research in Parkinson's disease, The National
Institute of Neurological Disorders and Stroke (NINDS) and the National
Institute of Environmental Health Sciences (NIEHS) invite qualified
investigators to submit grant applications for the establishment of
Morris K. Udall Parkinson's Disease Research Centers of Excellence.
The purpose of this Program Announcement (PA) is to encourage
additional research opportunities and discoveries that will lead to
improved diagnosis and treatment of patients with Parkinson's Disease
and related neurodegenerative disorders, based on a better
understanding of the fundamental cause(s) of the disease. It is
expected that these Centers will form a consortium of investigators
that will foster an environment that will enhance research
effectiveness in a multi-disciplinary setting, utilizing specialized
methods relevant to the study of these disorders. There were two
previous requests
(http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-98-001.html and
http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-99-004.html.
Expiration Date: Tuesday, February 25, 2003 NOFO Number: RFA-AR-03-001 Release Date: Monday, September 23, 2002 Notice Type: RFA
The purpose of this Request for Applications (RFA) is to establish Muscular
Dystrophy Cooperative Research Centers (MDCRCs), in order to increase basic
and clinical research on all forms of muscular dystrophy. The National
Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the
National Institute of Neurological Disorders and Stroke (NINDS), and the
National Institute of Child Health and Human Development (NICHD) invite
applications for MDCRCs that promote side-by-side basic, translational, and
clinical research, provide resources that can be used by the national muscle
biology and neuromuscular research communities, and provide training and
advice about muscle diseases for researchers and physicians who provide
initial diagnosis and treatment, including rehabilitation, care for cognitive
and behavioral concerns, and therapy for other system complications. Taken
together, the centers will constitute a cohesive program, the MDCRC Program,
operating under guidelines for NIH cooperative agreements.