This PA is a reissue of RFA MH-02-003.
The National Institute of Mental Health (NIMH), the National Institute on Aging
(NIA), National Institute of Alcohol Abuse and Alcoholism (NIAAA),
National Institute of Biomedical Imaging and Bioengineering (NIBIB), the
National Institute on Drug Abuse (NIDA), and National Institute of Neurological
Disorders and Stroke (NINDS) request research grant applications for the
development of novel radioligands for positron emission tomography (PET) and
single photon emission computed tomography (SPECT) imaging in human brain, and
that incorporate pilot or clinical feasibility evaluation in pre-clinical
studies, model development, or clinical studies.
This initiative is intended to facilitate the development of: 1) PET and SPECT
probes for molecular targets (e.g., receptors, intracellular messengers,
disease-related proteins) that are of broad interest to the neuroscience
research community, and 2) new technologies for radiotracer development.
The primary motivation for this initiative is the lack of versatile agonist and
antagonist PET and SPECT radiotracers for molecular targets that are implicated
in brain disorders. The use of radiotracers for imaging molecular events in
preclinical and clinical studies is essential for understanding the circuitry
that underlies normal brain function and the pathophysiology of brain disorders.
It is the intent of this initiative to foster the development of NIH
partnerships with scientists from pharmaceutical industry and academic nuclear
medicine research centers to develop ligands for PET and SPECT brain imaging
with the goal of making new radioligands accessible to the research community
as essential research tools for central nervous system (CNS) imaging, and as
potential biological markers and surrogate endpoints for translational and
clinical research, drug discovery and development, and clinical trials.
This solicitation will utilize the Phased Innovation Award Mechanism that is
intended to encourage the development and application of technology in
neurobiological research. Specific features of this mechanism include:
o Single submission and evaluation of both the R21 and R33 phases as one
application. An R33 application alone may be submitted.
o Expedited transition from the feasibility phase (R21) to the development
phase (R33) based on successful completion of negotiated quantitative
Milestones.
o Flexible staging of feasibility (R21) and development (R33) phases.
o Applications from industry or industry partnerships with other groups are
encouraged.
o Review of submissions by the Center for Scientific Review (CSR) and
expedited NIH programmatic review for transition from the R21 to the R33 phase.
Small businesses are encouraged to respond to the parallel PA, PA-02-028,
Development of PET and SPECT Ligands for Brain Imaging (SBIR Award)
http://grants.nih.gov/grants/guide/pa-files/PA-02-028.html. Its objectives are
identical; however, it will use the Small Business Innovation Research (SBIR)
and Small Business Technology Transfer (STTR) mechanisms. The same expedited
review and transition from Phase I to Phase II funding are expected to apply,
as will the same cost and time limitations as this PA for Phased Innovation
Awards.
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Expiration Date: Thursday, March 2, 2006 NOFO Number: PA-03-112 Release Date: Monday, April 21, 2003 Notice Type: PA
Expiration Date: Tuesday, May 2, 2006 NOFO Number: PA-03-107 Release Date: Friday, April 18, 2003 Notice Type: PA
This announcement redefines the National Institutes of Health (NIH)
Exploratory/Developmental Research Grant Award (R21) mechanism, and extends
its use as an investigator-initiated mechanism to the Institutes and Centers
(ICs) listed above. The R21 is intended to encourage exploratory and
developmental research projects by providing support for the early and
conceptual stages of these projects. The characteristics, requirements,
preparation, and review criteria for the R21 application are described.
Investigators wishing to apply for an R21 grant should be aware that not all
ICs accept investigator-initiated R21 applications. Investigators are
strongly encouraged to consult the R21 website at
http://grants.nih.gov/grants/funding/r21.htm to identify participating ICs
and relevant programmatic areas. Consultation with NIH staff listed on the
website is also encouraged. ICs that do not accept investigator-initiated
R21 applications may also solicit R21 applications to meet specific program
needs. Information related to the use of R21 awards by ICs that do not
participate in this program is also listed on the R21 website. Additional
information about special initiatives can be found in the NIH Guide for
Grants and Contracts at http://grants.nih.gov/grants/guide/index.html#search,
on IC websites, and through consultation with NIH staff. All investigator-
initiated exploratory/developmental grant applications described in this
announcement will be assigned to ICs according to standard PHS referral
guidelines and specific program interests.
Expiration Date: Tuesday, May 2, 2006 NOFO Number: PA-03-108 Release Date: Friday, April 18, 2003 Notice Type: PA
This announcement redefines the National Institutes of Health (NIH) Small
Grant (R03) mechanism, and extends its use to investigator-initiated
applications at the Institutes and Centers (ICs) listed above. The R03 award
supports small research projects that can be carried out in a short period of
time with limited resources. The characteristics, requirements, preparation,
and review criteria for the small grant application are described in this
document.
Investigators wishing to apply for an R03 grant should be aware that not all
ICs accept investigator-initiated R03 applications and that the different ICs
may have specific purposes for which they use this funding mechanism.
Therefore, all investigators should consult the R03 website at
http://grants.nih.gov/grants/funding/r03.htm as well as the IC staff listed
on this website to determine if an R03 application is appropriate.
Information related to the use of R03 awards by ICs that do not participate
in this program announcement is also listed on the R03 website. Additional
information about special initiatives involving R03 awards can be found by
searching the NIH Guide for Grants and Contracts at
http://grants.nih.gov/grants/guide/index.html#search, by examining IC
websites, and by consulting with NIH staff. All investigator-initiated small
grant applications described in this announcement will be assigned to the ICs
according to standard PHS referral guidelines and specific program interests.
Expiration Date: Wednesday, March 1, 2006 NOFO Number: PAR-03-106 Release Date: Thursday, April 17, 2003 Notice Type: PAR
Participating Institutes and Centers of the National Institutes of Health
(NIH) invite applications for innovative research in biomedical computational
science and technology to promote the progress of biomedical research.
There exists an expanding need to speed the progress of biomedical research
through the power of computing to manage and analyze data and to model
biological processes. The NIH is interested in promoting research and
developments in computational science and technology that will support rapid
progress in areas of scientific opportunity in biomedical research. As
defined here, biomedical computing or biomedical information science and
technology includes database design, graphical interfaces, querying
approaches, data retrieval, data visualization and manipulation, data
integration through the development of integrated analytical tools, and tools
for electronic collaboration, as well as computational and mathematical
research including the development of structural, functional, integrative,
and analytical models and simulations.
Expiration Date: Wednesday, August 2, 2006 NOFO Number: PAR-03-103 Release Date: Friday, April 11, 2003 Notice Type: PAR
The Neurological Sciences Academic Development Award (NSADA) (K12) is an award
to an educational institution or professional organization to support career
development experiences for pediatric neurologists leading to research
independence. This is a continuation of the original NSADA program, which was
initiated by NINDS in October 1992. Under this award, newly trained pediatric
neurologists are to be selected and appointed to this program by the grantee
institution. It is expected that individuals appointed to the NSADA program
will subsequently apply for their own Mentored Clinical Scientist Development
Award (K08) or the Mentored Patient-Oriented Career Development Award (K23) to
continue their research training (see "Research Objectives").
Candidates supported under this award should propose a research plan that has:
(1) intrinsic research importance, and (2) will serve as a suitable vehicle
for learning the methodology, theories, and concepts needed for a well-trained
independent clinician-researcher. The program should be designed to
accommodate research candidates with varying levels of experiences. For
example, a prospective research candidate with limited experience in a given
field of research may find it appropriate to engage in a structured, phased
developmental program, including a designated period of didactic training
followed by a period of supervised research experience. The entire program
should be comparable in scope and rigor to meeting the requirements for an
advanced research degree.
Expiration Date: Friday, November 26, 2004 NOFO Number: PA-03-097 Release Date: Tuesday, April 8, 2003 Notice Type: PA
The National Institute of Neurological Disorders and Stroke (NINDS) and the
National Institute of Child Health and Human Development (NICHD) invite
research grant applications aimed at understanding or treating Rett Syndrome
(RTT). The recent demonstration that mutations in the MeCP2 gene cause most
cases of RTT has created new opportunities for both basic and clinical
research. Included within the scope of this PA are developmental, molecular
genetic, and pathophysiological research, therapy development projects and
clinical studies. Studies of the role of MeCP2 in basic biological processes
or in the etiology of other neurological or neurobehavioral disorders are also
appropriate.
Expiration Date: Saturday, June 25, 2005 NOFO Number: PAR-03-096 Release Date: Monday, April 7, 2003 Notice Type: PAR
The above sponsoring Institutes and Agencies invite research grant
applications in response to this Program Announcement with Set-aside (PAS)
that will enhance our understanding of children exposed to domestic violence,
community violence, and war/terrorism. This PA is designed to develop new
knowledge in these areas and in the definition, identification, epidemiology,
prevention, etiology, effects, early intervention, and mechanisms of violence
exposure. This PA builds on recommendations from a recent multi-agency
research agenda-building workshop held in Washington, DC in July 2002. A
complete summary of the meeting presentations and recommendations is
available at http://www.nichd.nih.gov/crmc/cdb/cdb.htm.
Child exposure to violence is a serious public health, justice, social
services, and education problem. Such exposure not only compromises the
immediate health of children around the world, but also affects their growth
and intellectual development, their long-term physical and mental health
outcomes, their propensity for prosocial or antisocial behavior and substance
abuse, their future relationships with partners and children, and their
economic productivity as eventual wage earners. The need for more systematic
and multi-disciplinary research in these areas provides the impetus for this
PA.
Although not participating in this program announcement, the National
Institute of Mental Health (NIMH) shares an interest in this area of
research. For specific information on NIMH interests, see
http://www.nimh.nih.gov/grants/nimhviotrauma.cfm.
Expiration Date: Sunday, July 2, 2006 NOFO Number: PAS-03-092 Release Date: Monday, March 31, 2003 Notice Type: PAS
The goal of this Program Announcement (PA) is to promote the identification
of susceptibility genes for complex neurological and neurobehavioral
disorders. For this PA, complex disorders are defined as those caused by the
interaction of multiple genes, or by a combination of genetic and
environmental risk factors. Many of these disorders are relatively common
and clinically heterogeneous. Projects focusing on any phase of the gene
discovery process, from initial patient ascertainment to positional cloning,
are appropriate. Novel approaches, including the use of intermediate
phenotypes that potentially underlie complex disorders, are also encouraged.
Expiration Date: Tuesday, November 1, 2005 NOFO Number: PA-03-087 Release Date: Tuesday, March 25, 2003 Notice Type: PA
The National Institute of Neurological Disorders and Stroke (NINDS)
invites applications for individual postdoctoral National Research
Service Award fellowships (F32s) from physicians and basic scientists
interested in pursuing research related to HIV infection of the nervous
system. The intent of this Program Announcement (PA) is to encourage
research and career development for individuals with a strong
commitment to a research career in the area of NeuroAIDS, either in one
of the basic sciences relevant to NeuroAIDS or in clinically-oriented
research. Research related to the neuropathogenesis, the role of viral
or host genetic factors, inflammatory mechanisms, peripheral
neuropathy, or neurological dysfunction in the setting of anti-
retroviral therapy is of particular interest.
This PA follows the NRSA rules and regulations as outlined in
"RUTH L. KIRSCHSTEIN NATIONAL RESEARCH SERVICE AWARDS FOR INDIVIDUAL
POSTDOCTORAL FELLOWS (F32)" PA-03-067
(http://grants.nih.gov/grants/guide/pa-files/PA-03-067.html).
Expiration Date: Tuesday, November 1, 2005 NOFO Number: PA-03-086 Release Date: Tuesday, March 25, 2003 Notice Type: PA
The National Institute of Neurological Disorders and Stroke (NINDS) and
the National Institute of Mental Health (NIMH) invite applications for
Mentored Clinical Scientist Development Awards (K08s), or Mentored
Patient-Oriented Research Career Development Awards (K23s) from
physicians and basic scientists interested in pursuing research related
to HIV infection of the nervous system. The intent of this Program
Announcement (PA) is to encourage research and career development for
individuals with a strong commitment to a research career in the area
of NeuroAIDS, either in one of the basic sciences relevant to NeuroAIDS
or in clinically-oriented research. Research related to the
neuropathogenesis, the role of viral or host genetic factors,
inflammatory mechanisms, peripheral neuropathy, or neurological
dysfunction in the setting of anti-retroviral therapy is of particular
interest.