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This Program Announcement (PA) replaces PA-00-105 and PA-00-106. Under this PA, the National Institute of Mental Health, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Cancer Institute, National Institute of Child Health and Human Development, National Institute on Drug Abuse, and the National Institute of Neurological Disorders and Stroke invite research grant applications to expand basic and translational research on the processes and mechanisms involved in the experience and expression of emotion.

The goal of this Program Announcement with set-aside funds (PAS) is to invite applications for studying the neurobiological and cerebrovascular mechanisms through which the neuroprotective blood-brain and blood-csf barriers function in the healthy and diseased adult, aged and pediatric brain. Blood-Brain Barrier (BBB) research embodies the true meaning of a "translational model" of neuroscience wherein breakthroughs in basic neuroscience are delivered to the clinic and require an agent delivery strategy and/or the ability to target specific areas of the brain. This PAS encourages studies focused on improving our understanding of the neuroprotective CNS barriers and enhancing the effectiveness of drug and gene delivery strategies for treatment of neurological diseases. Chief among the challenges to be addressed is the need to increase our knowledge about the molecular and cellular biology, cells of origin, gene and protein expression, and the regional differences of brain microvascular endothelial cells and pericytes and their interactions with adjacent brain cells.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Eye Institute (NEI), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Nursing Research (NINR), National Institute of Child Health and Human Development (NICHD) invite the small business community to apply cutting edge technology to research to develop new approaches to prevent, treat, and cure type 1 diabetes and its complications. This RFA will utilize the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) mechanisms, but will be run in parallel with other requests for applications (RFAs) of similar scientific scope (DK- 03-015 for Innovative Partners and DK-03-001 for Bench to Bedside) that will utilize the traditional research project grant (R01), the exploratory/developmental grant (R21) or the exploratory/developmental grant phase II (R33) grant mechanisms.

Through this Program Announcement with set-aside funds (PAS), the National Institute of Neurological Disorders and Stroke invites applications to support research on reducing disparities in stroke through prevention of first and recurrent strokes among minority populations. For this PAS, minority group is defined by race/ethnicity, and includes African American, Hispanic American, Native American and Alaska Native, and Native Hawaiian and other Pacific Islanders. The purpose of the proposed grant program is to foster empirical research regarding interventions relating to the self-management of risk factors for first and recurrent stroke among members of minority populations.

The NINDS invites applications to validate animal models of pharmacoresistant epilepsy or intervention in the epileptogenic processes leading to chronic disease. The goal of this grant program is to validate proposed models of pharmacoresistant epilepsy and/or antiepileptogenic models for use in drug discovery. It will establish baseline data and introduce new methods for evaluating the therapeutic potential of novel compounds for the treatment of epilepsy.

Through this Program Announcement with set-aside funds (PAS), the National Institute of Neurological Disorders and Stroke invites applications to support research on reducing disparities in the treatment of epilepsy among minority populations. For this PAS, minority population is defined by race/ethnicity, and includes African Americans, Hispanic Americans, Native Americans and Alaska Natives, and Native Hawaiians and other Pacific Islanders. The purpose of the proposed grant program is to foster empirical research that will identify effective interventions to overcome the key barriers to, and mediators of, treatment for epilepsy experienced by minority groups and, thereby, improve the patterns of epilepsy care among these populations.

This is a reissuance of RFA DK-03-001. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Eye Institute (NEI), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Neurological Disorders and Stroke (NINDS), and the Office of Dietary Supplements (ODS) invite applications involving partnerships between clinical and basic biomedical researchers with the goal of translating advances in our understanding of the molecular basis of type 1 diabetes and its complications into new therapies for the prevention, treatment and cure of this disease. In these "bench to bedside" research partnerships, a team of clinical and basic scientists will conduct collaborative research that, if successful, will bring basic research advances from the laboratory to a point where a potential new therapy can be tested in patients or in preclinical studies in animal models.

The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for basic studies that define therapeutic opportunities during the progressive stages of spinal cord injury (SCI) from acute through chronic time points. Although numerous neuroprotective and repair strategies have been identified that improve anatomical or functional outcome after SCI in animal models, the causal relationship between cellular or anatomical findings and functional outcomes has not been established. This RFA seeks research to 1) elucidate the mechanisms that underlie recovery induced by neuroprotection or repair strategies in animal models, 2) define progressive changes in acute, subacute or chronic stages after SCI that influence cell survival, regeneration, sprouting and/or recovery of function, 3) target therapeutic strategies in animal models to clinically-relevant stages and types of SCI, based on known pathophysiological processes, anatomical or functional/clinical outcomes.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Neurological Disorders and Stroke (NINDS) invite applications for basic and clinical studies to enhance understanding and prevention of hypoglycemia in patients with diabetes. Large clinical trials have demonstrated the efficacy of intensified glucose control in the prevention of the long-term vascular complication of diabetes. However, episodes of severe hypoglycemia may complicate intensified treatment and are often a major obstacle to the achievement of euglycemia in many patients. This RFA seeks basic and clinical studies to 1) enhance understanding of how the brain and other critical tissues sense and respond to hypoglycemia, 2) delineate the effects of hypoglycemia on brain function and 3) develop improved methodologies to prevent hypoglycemia, based on an understanding of physiological glucose sensing and counterregulation.

With this Announcement, the Department of Veterans Affairs (VA), the National Institute of Neurological Disorders and Stroke (NINDS) and the Amyotrophic Lateral Sclerosis Association (ALSA) invite research grant applications that address the etiology, pathogenesis and treatment of Amyotrophic Lateral Sclerosis.