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- The objective of the Career Development Award to Promote Diversity in Neuroscience Research is to promote diversity among faculty-level neuroscience investigators who are competitively funded to conduct independent research. - Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. - The type of mechanism used for these awards is the Mentored Research Scientist Development Award (K01). - Eligible organizations include domestic for-profit or non-profit organizations, public or private institutions such as universities, colleges, hospitals, and medical, dental, or nursing schools or other institutions of higher education involved in neurological research - Eligible principal investigators include those individuals making the transition to an independent scientific career at the senior post-doctoral and junior faculty stages who come from groups that have been shown to be underrepresented in neuroscience research. Such candidates include individuals from underrepresented racial and ethnic groups, individuals with disabilities, and individuals from disadvantaged backgrounds. - Review criteria include: (1) qualifications of the candidate; (2) the soundness of the proposed career development plan; (3) training in the responsible conduct of research; (4) the nature and scientific/technical merit of the proposed research plan; (5) the qualifications and appropriateness of the mentor/co-mentor; (6) environment and institutional commitment to the candidate's career; and (7) the strength of the description of how this particular award will promote diversity within the institution or in science nationally. - There is no limit on the number of applications that may be submitted by an institution. - Applications must be prepared using Section IV of the PHS 398 research grant application instructions and forms (rev. 9/2005). The PHS 398 is available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- NINDS Center Core Grants will support centralized resources and facilities shared by investigators with existing NINDS-funded research projects. Each Center will be composed of one or more research cores, each of which will enrich the effectiveness of ongoing research, and promote new research directions. There should be no overlap between the requested core facilities and other pre-existing core facilities - An applicant organization is eligible for a maximum of one NINDS Center Core Grant. Applicants may request up to $500,000 per year in direct costs. - This PA will use the NIH Center Core Grants (P30) award mechanism. - Eligible organizations include for-profit and non-profit organizations, public or private institutions, such as universities, colleges, hospitals, and laboratories, units of State and local governments, eligible agencies of the federal government, domestic institutions, and faith-based or community-based organizations. - Eligible principal investigators include any individuals with the skills, knowledge, and resources necessary to carry out the proposed research. - NINDS will not consider more than one application simultaneously from an applicant organization. - Application materials are available at http://grants.nih.gov/grants/funding/phs398/phs398.html. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- This PAR is for projects from individual-investigators or small groups to collaborate with the recently-formed NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs) For a description of the NCBCs see http://www.bisti.nih.gov/ncbc/index.cfm. - The intention of the collaborating projects is to engage researchers across the nation in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. - Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. - This PAR will use the R01 mechanism Successful applications will be funded by the participating ICs. - Eligible organizations include : for-profit or non-profit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of state and local governments; eligible agencies of the Federal government; domestic or foreign institutions/organizations - Eligible PIs include any individual with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - There is no limit to the number of scientifically different applications that each applicant may submit. However, each application must include a letter of support from the PI of the NCBC with whom the collaboration is proposed. - Application forms are available at http://grants.nih.gov/grants/funding/phs398/phs398.html. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

Biomedical research laboratories increasingly undertake a software development project to solve a problem of interest to that laboratory. These software packages sometimes become useful to a much broader community of users that can include translational and clinical researchers. The goal of this program announcement is to support the continued development, maintenance, testing and evaluation of existing software. The proposed work should apply best practices and proven methods for software design, construction, and implementation to extend the applicability of existing biomedical informatics/computational biology software to a broader biomedical research community. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon number, quality, duration, and costs of the applications received. This program announcement uses the R01 mechanism as well as supplements to existing NIH awards. Eligible organizations include for-profit or non-profit organizations, public or private institutions, units of state and local governments, eligible agencies of the Federal government, and either domestic or foreign organizations. There is no limit on the number of applications that may be submitted. Applicants must use the most recent version of the PHS 398 form. That form is available at http://grants.nih.gov/grants/forms.htm. Telecommunications for the hearing impaired is available at: TTY 301-451-0088.

- The purpose of this PAR is to invite qualified scientific investigators to submit applications designed to identify small molecule reagents that specifically prevent or ameliorate a protein folding or processing defect in simple and complex genetic diseases that are of interest to the participating institutes. - This funding opportunity will use the NIH Research Project Grant (R01) and Exploratory/Developmental Grant (R21) award mechanisms. The total project period for an application in response to this PAR may not exceed the following durations: 2 years for the R21, and 5 years for the R01. Exploratory/developmental grant applications are highly encouraged. - Organizations that have any of the following characteristics may submit applications: For profit or non-profit, public or private institutions, such as universities, colleges, hospitals, and laboratories, units of State and local governments, and domestic or foreign institutions/organizations. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - Applicants may submit more than one application, providing there is no scientific or budgetary overlap. The PHS 398 application instructions are available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. For further assistance contact GrantsInfo, Telephone (301) 435-0714, Email: GrantsInfo@nih.gov. Telecommunications for the hearing impaired is available at: TTY 301-451-0088.

- The Jointly Sponsored NIH Predoctoral Training Program in the Neurosciences supports broad and fundamental, early-stage graduate research training in the neurosciences via institutional training grants. - Because the nature and scope of the proposed research training will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards made will depend upon the number, quality, duration, and costs of the applications received. - This PA will use the NIH Ruth L. Kirschstein National Research Service Award (NRSA) mechanism (T32). - Only domestic, non-profit, public or private institutions may apply for grants to support research training programs. - Eligible Training Program Directors include any individual with the skills, knowledge, and resources necessary to carry out the proposed predoctoral training program in the neurosciences. Training Program Directors should have a strong track record in neuroscience research and graduate research training and be capable of providing both scientific and administrative leadership for the proposed training program. - An eligible institution may submit only a single application and may only have a single training program supported by this funding opportunity. - The PHS 398 application kit is available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

The National Institute of Mental Health (NIMH), National Institute on Aging (NIA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Drug Abuse (NIDA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), and National Institute on Neurological Disorders and Stroke (NINDS) request research grant applications to study neuroimmune molecules and mechanisms involved in regulating normal and pathological central nervous system (CNS) function. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. This PA will use the NIH R01, R21, and R03 award mechanisms. Applications may be submitted by domestic or foreign, for-profit or non-profit organizations, public or private institutions, such as universities, colleges, hospitals, and laboratories; units of State and local governments; eligible agencies of the Federal government. Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. There is no limit on the number of applications that may be submitted. Applications must be prepared using the PHS 398 research grant application instructions and forms. The PHS 398 is available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. For further assistance contact GrantsInfo, Telephone (301) 435-0714, Email: GrantsInfo@nih.gov.

-The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Child Health and Human Development (NICHD), the National Institute of Neurological Disorders and Stroke (NINDS), and the NIH Office of Dietary Supplements (ODS) are interested in supporting additional training fellowship opportunities in muscle disease research. Diseases for this program announcement include, but are not limited to muscular dystrophies such as Duchenne, myotonic and facioscapulohumeral; myotonias and disorders of muscle membranes such as malignant hyperthermia; muscle wasting disorders (e.g. sarcopenia); inflammatory myopathies; and electrolyte disorders. - The number of awards and the total amount of funding that the NIAMS, NICHD, NINDS and ODS expect to award through this announcement will depend on the number of applications and the quality of the applications. - This announcement uses the Ruth L. Kirschstein National Research Service Award (NRSA) for Individual Postdoctoral Fellows (F32) (see http://grants.nih.gov/grants/guide/pa-files/PA-03-067.html). - Eligible organizations include for-profit and non-profit organizations, public or private institutions such as universities, colleges, hospitals and laboratories, units of State and local governments, eligible agencies and labs of the Federal government including NIH intramural labs, domestic or foreign institutions/organizations. - Trainees must be citizens or non-citizen nationals of the United States, or have been lawfully admitted to the United States for permanent residence and have in their possession an Alien Registration Receipt Card (I-151 or I-551) at the time of award. - An individual may not have two or more competing NIH fellowship applications pending review concurrently. In addition, CSR will not accept for review any application that is essentially the same as one already reviewed. This does not preclude the submission of a substantial revision of an application already reviewed, but such application must include an Introduction addressing the previous critique. - Application materials and instructions are available at: http://grants.nih.gov/grants/funding/416/phs416.htm. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Child Health and Human Development (NICHD), the National Institute of Neurological Disorders and Stroke (NINDS), and the NIH Office of Dietary Supplements (ODS) are interested in supporting additional career development and mentoring opportunities in muscle disease research. Diseases for this program announcement include, but are not limited to muscular dystrophies such as Duchenne, myotonic and facioscapulohumeral; myotonias and disorders of muscle membranes such as malignant hyperthermia; muscle wasting disorders (e.g. sarcopenia); inflammatory myopathies; and electrolyte disorders. - Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. - This announcement will use the Mentored Clinical Scientist Development Award (K08) and the Mentored Patient-Oriented Research Career Development Award (K23). - Eligible organizations include domestic, for-profit and non-profit organizations, public or private institutions such as universities, colleges, hospitals and laboratories. - Trainees must be citizens or non-citizen nationals of the United States, or have been lawfully admitted to the United States for permanent residence and have in their possession an Alien Registration Receipt Card (I-151 or I-551) at the time of award. Each funding mechanisms has specific requirements for academic degree and/or research program. - A candidate for the K awards may not concurrently apply for or have an award pending for another NIH career development award. - Applications should be on the PHS 398 form for Research Career Development Awards. Materials and instructions are available at: http://grants.nih.gov/grants/funding/phs398/phs398.html - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- As summarized in the 2003 National Sleep Disorders Research Plan (http://www.nhlbi.nih.gov/health/prof/sleep/res_plan/index.html), multiple scientific areas in sleep and sleep disorders need additional research. In addition, therapy for a number of sleep disorders remains suboptimal, and the research workforce addressing sleep science is insufficient. The NHLBI, National Center on Sleep Disorders Research, and co-sponsoring member Institutes and Centers of the Trans-NIH Sleep Research Coordinating Committee therefore invite submission of grant applications proposing research to advance biomedical knowledge related to sleep or sleep disorders, improve understanding of the neurobiology or functions of sleep over the life-span, enhance timely diagnosis and effective treatment for individuals affected by sleep-related disorders, or implement and evaluate innovative community-based public health education and intervention programs. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism, numbers, quality, duration , and costs of the applications received. - This PA will use the NIH R01and R21 award mechanisms. - Eligible organizations include institutions with any of the following characteristics: - For-profit or non-profit organizations - Public or private institutions, such as universities, colleges, hospitals, and laboratories - Units of State and local governments - Eligible agencies of the Federal government - Domestic or foreign institutions/organizations - Faith-based or community-based organizations - Eligible principal investigators include individual with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - There is no limit on the number of applications that may be submitted. - One can get application materials at http://grants.nih.gov/grants/forms.htm - Telecommunications for the hearing impaired is available at: TTY 301-451-0088