The National Institutes of Health (NIH) invite applications for specialized Centers to accelerate application of the latest advances in human stem cell biology for the development of novel diagnostic or therapeutic uses, and of preclinical studies employing human stem cells in animal models of disease. The P50 mechanism will be used to create three Centers of Excellence in Translational Human Stem Cell Research. These centers will bring together basic stem cell biologists, researchers and clinicians with disease-specific expertise, physicians and surgeons skilled in novel modes of cell delivery, and investigators experienced in developing and assessing animal models of human diseases to create new research teams, and to conduct hitherto-unexplored projects such as preclinical studies for cell-based therapy. This initiative targets critical gaps in research that are delaying the conversion of new discoveries to new therapies, and particularly encourages the formation of new, multidisciplinary teams involving scientists that may not have worked in the human stem cell field and those that incorporate the full spectrum of expertise and experience in translational medical research. We anticipate that such research will ultimately lead to innovative approaches for the prevention, treatment, and cure of disease, and accelerate the translation of basic scientific discoveries in the laboratory to new treatments for patients. The NIH intends to commit up to $4.5 million dollars in FY 2005 to fund three new Centers. Eligible organizations include domestic public or private institutions. There is no limit on the number of applications from an institution or individual. Any individual with the skills, knowledge and resources necessary to carry out the proposed research is invited to work with the institution to develop and application for support. Individuals from underrepresented or disadvantaged groups are always encouraged to apply for NIH programs. The PHS 398 application instructions are available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. For further assistance contact Grantsinfo, Telephone (301) 435-0714, Email: Grantsinfo@nih.gov.
Find Funding Opportunities
COVID-19 Funding Notices | Approved Initiative Concepts | Research Opportunity Announcements
All NINDS-related notices of funding opportunities (NOFOs), request for applications (RFAs), program announcements (PAs), and other NIH Guide announcements are listed. Search the Closed Opportunities tab to find expired opportunities. Search the Notices tab to find all Notices.
Learn more about award types and program directors and managers.
NINDS has a number of open positions for researchers and clinicians to contribute to exciting neuroscience programs - APPLY NOW!
For more focused results add quotes to indicate parameters. Example format: "search term".
Expiration Date: Friday, March 25, 2005 NOFO Number: RFA-NS-05-005 Release Date: Wednesday, September 29, 2004 Notice Type: RFA
Expiration Date: Thursday, October 20, 2005 NOFO Number: PA-04-161 Release Date: Wednesday, September 29, 2004 Notice Type: PA
On February 26, 2004, Executive Order 13329
(http://a257.g.akamaitech.net/7/257/2422/14mar20010800/edocket.access.gp…
/2004/pdf/04-4436.pdf)was signed by President George W. Bush requiring
SBIR/STTR agencies, to the extent permitted by law and in a manner consistent
with the mission of the Department, to give high priority within the SBIR and
STTR programs to manufacturing-related research and development (R&D). In
response to this Executive Order, NIH, CDC, and the FDA are expanding their
foci by encouraging biomedical research related to advanced processing,
manufacturing processes, equipment and systems, and manufacturing workforce
skills and protection.
Expiration Date: Tuesday, January 25, 2005 NOFO Number: RFA-NS-05-004 Release Date: Thursday, September 2, 2004 Notice Type: RFA
The Neurodegeneration and Clinical Trial Groups of the National
Institute of Neurological Disorders and Stroke (NINDS) request
applications for additional clinical centers to collaborate in clinical
trials to test potential neuroprotective agents in Parkinsons disease
(PD). These studies, the neuroprotection exploratory trials in PD (NET-
PD) include pilot clinical trials and plans for a large, simple phase
III clinical trial. Previous solicitations were issued for the clinical
and statistical coordinating centers
(http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-01-012.html)
and clinical centers
(http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-02-010.html.
Pilot clinical trials are ongoing with over forty
participating sites. The agents under study currently include
creatine, minocycline, Coenzyme Q10, and a neuroimmunophilin ligand.
These pilot studies are expected to complete follow-up in the 3rd
quarter of 2005. Depending upon the results of these studies a phase
III trial with one of these agents may be conducted or additional pilot
studies of different agents may be performed. Sites are sought to join
NET-PD to participate in these future studies.
Expiration Date: Wednesday, January 3, 2007 NOFO Number: PA-04-154 Release Date: Thursday, September 2, 2004 Notice Type: PA
This PA replaces PA-01-072.
The National Institute of Mental Health (NIMH), National Institute of Neurological
Disorders and Stroke (NINDS), National Institute on Drug Abuse (NIDA), and National
Institute of Alcohol Abuse and Alcoholism (NIAAA) invite research grant
applications through this Program Announcement (PA) to support research focused on
determining the pathogenic mechanisms involved in Human Immunodeficiency Virus
(HIV)-1 associated neurobehavioral and neurological dysfunction in domestic and
international settings. The objective of this cooperative effort is to foster
investigations that will provide the foundation for the rapid development of
therapeutic interventions to prevent and treat the effects of HIV-1 on the central
nervous system (CNS). Applications ranging from basic research to clinical
diagnosis and treatment are of interest. Multidisciplinary research teams and
collaborative alliances are encouraged but not required.
Expiration Date: Wednesday, December 22, 2004 NOFO Number: RFA-AG-05-006 Release Date: Thursday, September 2, 2004 Notice Type: RFA
The NIA and NINDS encourage wider use of data and samples generated by
grants supported by the institute(s) including the Alzheimers Disease
Centers (ADCs). The purpose of this RFA is to accelerate collaborative
cross-disciplinary and multi-institutional approaches that will
contribute new and vital information about the clinical and
pathological course of normal aging and the neurodegenerative diseases
associated with aging.
This RFA requires the utilization of data and/or samples from at least
three currently funded NIA ADCs with the possibility of using
additional relevant data or samples from outside of the Centers. The
project must use the National Alzheimers Coordinating Center (NACC)
http://www.alz.washington.edu/ for expert advice on planning, study
design, and also utilize NACC for statistical analyses and data
management during conduct of the research projects. Applicants can be
from the Alzheimers Disease Centers, the Morris K. Udall Centers, or
the research community at large. There should be a plan to share data
originating from these studies by archiving them at NACC or another
appropriate National databank so that other investigators will be able
to conduct additional analyses when appropriate. There must also be a
plan to encourage sample utilization after the current study.
This is a research opportunity for scientists both within and outside
the ADCs to gain access to unique resources related to Alzheimers
Disease, other neurodegenerative diseases, and normal aging and to
support collection of new data and samples. Applicants can also propose
to utilize Center data and samples to investigate other age-related
neurodegenerative diseases, such as Vascular dementia, Parkinsons
dementia, Lewy Body disease, Fronto-Temporal dementia, as well as study
psychiatric symptoms associated with dementia, sociobehavioral aspects
of dementia, and management and care of dementia patients.
The National Institute of Neurological Disorders and Stroke (NINDS) is
interested in those specific applications which include the Morris K.
Udall Centers of Excellence, or other Parkinsons research centers, in
the pursuit of those research objectives focused on Parkinson's Disease
(PD) or related parkinsonisms. The PD center need not be located with
ADCs, but collaboration with those ADCs with existing samples and data
sets focused on PD is required. Specific scientific projects of
interest include the use of clinico-pathological correlations to study
mechanisms of pathogenesis in PD or other parkinsonian conditions,
characterization of the pathological features of these conditions, and
the collection of patient data on their associated symptoms.
Expiration Date: Wednesday, January 3, 2007 NOFO Number: PAS-04-149 Release Date: Friday, August 20, 2004 Notice Type: PAS
The purpose of this Program Announcement with set-aside funds (PAS) is to
invite applications to study the biological basis of vascular cognitive
impairment (VCI). VCI causes a burden of illness similar to that caused by
Alzheimers disease (AD), but has been far less well-studied. Recently,
however, some important strides have been made in understanding the etiology
of VCI. These include the discovery of a monogenic form of vascular
dementia, CADASIL, and identification of the causative gene as Notch 3. In
addition, MRI and other pathological data have provided a clearer delineation
of the various clinical subtypes of VCI, and awareness of the synergistic
interaction between vascular and classical Alzheimers pathologies in
producing cognitive impairment. The goal of this PAS is to build on these
first critical achievements to obtain a better understanding of the cellular
and molecular mechanisms causing vascular, neural, and glial dysfunction in
human VCI and animal models of VCI.
Expiration Date: Tuesday, November 23, 2004 NOFO Number: RFA-NS-05-003 Release Date: Friday, August 6, 2004 Notice Type: RFA
The Office of Research Integrity (ORI, DHHS), the National Institute of
Neurological Disorders and Stroke (NINDS, NIH), the National Institute
of Nursing Research (NINR, NIH), the National Institute on Drug Abuse
(NIDA, NIH), and the Agency for Healthcare Research and Quality (AHRQ,
DHHS) invite applications to support research on research integrity.
The purpose of the proposed grant program is to foster empirical
research on societal, organizational, group, and individual factors
that affect, both positively and negatively, integrity in research.
Proposals must have clear relevance to biomedical, behavioral health
sciences, and health services research. Applicants are strongly
encouraged to take into consideration problems or issues that are
relevant to the missions of DHHS, NIH, AHRQ, or specific NIH institutes
and programs.
For the purposes of this RFA, "research" is interpreted broadly to
include societal, organizational, group, and individual aspects of the
enterprise. "Integrity" is understood as "the use of honest and
verifiable methods in proposing, performing, and evaluating research
and reporting research results with particular attention to adherence
to rules, regulations, guidelines, and commonly accepted professional
codes or norms."
Expiration Date: Wednesday, January 12, 2005 NOFO Number: RFA-HL-05-004 Release Date: Friday, July 23, 2004 Notice Type: RFA
PURPOSE OF THIS RFA
Ischemic stroke is the third leading cause of death in the United States. With the
aging of the population, the number of stroke patients in the US is likely to grow.
There is a critical need to develop safe and effective therapies to improve the
clinical management of stroke patients. Thus, the NHLBI and the NINDS invite
research applications that will improve the understanding of brain hemostasis,
identify new molecular targets, explore promising agents, and develop novel
therapeutics for cerebral ischemia. This program intends to support basic,
translational, and early clinical studies.
Expiration Date: Thursday, November 2, 2006 NOFO Number: PAS-04-130 Release Date: Thursday, July 22, 2004 Notice Type: PAS
This Program Announcement with Set-Aside fosters co-operation between
investigators and joint research projects to understand how fate choices are
made by stem and precursor cells in the nervous system, and to design,
refine, and improve upon the use of stem cells for diagnostic or therapeutic
applications for neurological disorders. The National Institute of
Neurological Disorders and Stroke (NINDS) is interested in supporting
research that combines the unique and complementary expertise of laboratories
from the United States and abroad, applying different disciplines,
techniques, model systems or tissues. We anticipate that such research will
ultimately lead to innovative approaches for the prevention, management and
treatment of disorders of the nervous system, and encourage collaborations
from disparate scientific areas and disciplines, including those not
traditionally supported by the NINDS. It is essential, however, that the
proposed activities be within the mission of the NINDS.
Expiration Date: Monday, September 8, 2008 NOFO Number: PA-04-126 Release Date: Friday, July 9, 2004 Notice Type: PA
The participating Institutes and Centers of the National Institutes of
Health (NIH) along with the Office of Research on Womens Health
announces a continuing program for administrative supplements to
research grants to support individuals with high potential to reenter
an active research career after taking time off to care for children or
attend to other family responsibilities. The aim of these supplements
is to encourage such individuals to reenter research careers within the
missions of all the program areas of NIH. This program will provide
administrative supplements to existing NIH research grants for the
purpose of supporting full-time or part-time research by these
individuals in a program geared to bring their existing research skills
and knowledge up to date. It is anticipated that at the completion of
the supplement, the reentry scientist will be in a position to apply
for a career development (K) award, a research award, or some other
form of independent research support.
The NIH recognizes the need to increase the number of underrepresented
racial and ethnic groups, women, individuals with disabilities, and
people from disadvantaged backgrounds in biomedical, behavioral,
clinical and social science research careers. Among the reasons for the
low representation of women may be the fact that women bear a majority
of the responsibilities surrounding child and family care. To address
this issue, this program is designed to offer opportunities to women
and men who have interrupted their research careers to care for
children or parents or to attend to other family responsibilities. A
second objective of the program is to mentor and guide those who
receive support to reestablish careers in biomedical, behavioral,
clinical or social science research. Participating NIH institutes and
centers are listed at the end of the announcement.