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Purpose. The NIH invites applications for Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54s). The overall mission of the CounterACT Research Network is to develop new and improved medical countermeasures against chemical threats (see http://www.ninds.nih.gov/funding/research/counterterrorism/index.htm). Chemical threats include pulmonary agents such as chlorine, industrial chemicals such as cyanide, and nerve agents such as sarin.Unlike the previous CounterACT Funding Opportunity Announcements (FOAs), research on sulfur mustard countermeasures will not be supported by this announcement.Each new CounterACT Center of Excellence will be composed of an administrative core, three scientifically related research and development sub-projects, and one scientific core if needed and justified.This RFA announces a limited competition: Two of the three subprojects within the new Center must be Cooperative Agreement Research Projects (U01s) or SBIR Projects (U44s) that are already funded by CounterACT.The third sub-project can also be another previously-funded CounterACT U01 or U44, or it can be a new project that is fully integrated into the other projects and Center objectives. Applicants must demonstrate that the formation of a new Center will provide synergism to the overall goal of countermeasure development.One or two new specific aims within the previously-funded projects may be supported to help meet this requirement.
-Purpose. The NIH invites applications for Countermeasures Against Chemical Threats (CounterACT) Advanced Development Cooperative Agreements (U01s).The overall mission of the CounterACT Research Network is to develop new and improved medical countermeasures against chemical threats (see http://www.ninds.nih.gov/funding/research/counterterrorism/index.htm). These include pulmonary agents such as chlorine, industrial chemicals such as cyanide, and nerve agents such as sarin.Unlike the previous CounterACT Funding Opportunity Announcements (FOAs), sulfur mustard research will not be supported by this announcement, research on diagnostic technologies will not be supported, and the focus will be on therapies that can be used after exposure to a chemical threat as opposed to pre-exposure prophylactic treatments.The expected outcome of each of these accelerated three-year projects is a lead compound or validated model for screening relevant therapeutics. -Mechanism of Support. This FOA will utilize the Research Project Cooperative Agreement (U01) award mechanism. -Funds Available and Anticipated Number of Awards.The NIH intends to commit approximately $2.5 million in Fiscal Year 2008 to fund 4-6 CounterACT research projects as cooperative agreements (U01s).Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.