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Purpose. This Funding Opportunity Announcement (FOA) encourages research grant applications from institutions/organizations to develop novel, robust analytical platforms using in vitro assays to reveal changes in neuronal and/or glial function. The goal is to adapt state-of-the-art measures of basic cellular processes or molecular events that are key mediators of brain function with the intent to probe mechanisms and/or perturbations in an unbiased and efficient manner. The novel assay platforms would provide opportunities to measure neurobiological endpoints and build a pipeline to be used in the context of target identification and drug discovery. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism Funds Available and Anticipated Number of Awards. The NIMH intends to commit approximately $3 million total costs in FY 2011 to fund 5-10 awards and NINDS intends to commit approximately $2 million total costs in FY 2011 to fund 3-6 awards.

Purpose. This Funding Opportunity Announcement (FOA) is a program announcement (PA) issued by the National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Environmental Health Sciences (NIEHS), and Office of Research on Womens Health, National Institutes of Health (NIH). It encourages R21 grant applications from institutions/organizations that intend to perform innovative research that will expand our current knowledge of neurobiological mechanisms underlying migraine headache, examine the role of neuromodulators, genetic and environmental influences in migraine susceptibility, and explore new targets for therapy development. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with a FOA of identical scientific scope, PA-10-258, that encourages applications under the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism, numbers, quality, duration, and costs of the applications received.

Purpose. This Funding Opportunity Announcement (FOA) is a program announcement (PA) issued by the National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Dental and Craniofacial Research (NIDCR), and National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). It encourages R01 grant applications from institutions/organizations that intend to perform innovative research that will expand our current knowledge of neurobiological mechanisms underlying migraine headache, examine the role of neuromodulators, genetic and environmental influences in migraine susceptibility, and explore new targets for therapy development. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with a FOA of identical scientific scope, PA-10-259, that encourages applications under the NIH Exploratory/Developmental (R21) mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

Purpose. This FOA issued by the NIH Basic Behavioral and Social Sciences Opportunity Network (OppNet) solicits exploratory/developmental (R21) research applications examining basic mechanisms of self-regulation. The intent of this FOA is to advance research on basic processes and mechanisms of self-regulation, capitalizing on recent advances in methods and theory from the psychological (social, personality, developmental), economic, neuroscience, sociocultural, and other behavioral and social science literatures. The current lack of consistency and conceptual integration in how self-regulation is studied across a range of disciplines hinders our understanding of the basic mechanisms underlying many important health and developmental outcomes. Applications submitted to this FOA are expected to address one or more of the following basic behavioral and social science research (b-BSSR) challenges: (1) to precisely identify and operationally reconcile the basic processes and mechanisms involved in self-regulation of cognition, emotion, and behavior, and refine their measurement and theoretical conceptualizations, (2) to assess relations among various self-regulatory functions and their sub-components, and (3) to systematically characterize changes in self-regulatory functions over time, across different social and environmental contexts, and across the lifespan in both men and women. Proposals are expected to engage investigators working at multiple levels of analysis and across disparate literatures. Mechanism of Support. This FOA will utilize the R21 award mechanism. Funds Available and Anticipated Number of Awards. OppNet intends to commit approximately $1,900,000 in total costs (Direct plus Facilities and Administrative (F&A) costs) in FY 2011 to fund 6-8 new grants in response to this FOA.

Purpose. This funding opportunity announcement (FOA) issued by the Fogarty International Center (FIC), together with the Office of Dietary Supplements (OD/ODS), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), the National Institute on Aging (NIA), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Environmental Health Sciences (NIEHS), encourages applications for the Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) D43 program for collaborative research training between institutions in the U.S. and low-and middle-income countries (LMIC), defined by the World Bank classification system. The proposed institutional research training program is expected to sustainably strengthen the research capacity of the LMIC institutions, and to train in-country experts to conduct research on chronic, non-communicable diseases and disorders across the lifespan, with the ultimate goal of implementing evidence-based interventions relevant to their countries. Mechanism of Support: This FOA will use the NIH Institutional Research Training D43 grant mechanism. Training programs may not be transferred from one institution to another. (See section VI.2.) Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed international research training program will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the numbers, quality, duration, and costs of the applications received.

Purpose. This FOA issued by the Basic Behavioral and Social Sciences Research Opportunity Network (OppNet), National Institutes of Health, solicits Research Project Grant (R01) applications from institutions/organizations that propose to investigate the reciprocal interactions of the processes of sleep and circadian regulation and function with behavioral and social environment processes. Sleep is a complex biological phenomenon that is essential to normal behavioral and social functioning, as well as optimal health. In spite of its vital nature, the mechanisms by which social environment factors affect sleep behavior patterns have not been studied systematically, especially within the contexts of individual vulnerabilities and resilience. There is a need for greater understanding of the dynamic relationships between behavioral and social environment factors on the one hand and the basic mechanisms of sleep-wake and circadian regulation and function on the other. This FOA is not intended to support research on or development of treatments or interventions for disorders of sleep or circadian rhythms. Mechanism of Support. This FOA will utilize the R01 award mechanism and runs in parallel with a FOA of identical scientific scope, RFA-HD-11-102, that encourages applications under the R21 award mechanism. Funds Available and Anticipated Number of Awards. OppNet intends to commit up to $2 million in FY 2011 to fund 5-6 applications submitted in response to this FOA, pending the number and quality of applications and availability of funds.

Purpose. This FOA issued by the Basic Behavioral and Social Sciences Research Opportunity Network (OppNet), National Institutes of Health, solicits Research Project Grant (R21) applications from institutions/organizations that propose to investigate the reciprocal interactions of the processes of sleep and circadian regulation and function with behavioral and social environment processes. Sleep is a complex biological phenomenon that is essential to normal behavioral and social functioning, as well as optimal health. In spite of its vital nature, the mechanisms by which social environment factors affect sleep behavior patterns have not been studied systematically, especially within the context of individual vulnerabilities and resilience. There is a need for greater understanding of the dynamic relationships between behavioral and social environment factors on the one hand and the basic mechanisms of sleep-wake and circadian regulation and function on the other. This FOA is not intended to support research on or development of treatments or interventions for disorders of sleep or circadian rhythms. Mechanism of Support. This FOA will utilize the R21 award mechanism and runs in parallel with a FOA of identical scientific scope, RFA-HD-11-101, that encourages applications under the R01 award mechanism. Funds Available and Anticipated Number of Awards. OppNet intends to commit up to $1 million in FY 2011 to fund 5-6 applications submitted in response to this FOA, pending the number and quality of applications and availability of funds.

Purpose. This FOA, issued as part of the NIH Basic Behavioral and Social Science Opportunity Network (OppNet), solicits Research Project Grant (R01) applications from institutions/organizations that propose to investigate structural, behavioral, sociocultural, environmental, cognitive, emotional, and/or biological mechanisms through which the social environment affects health outcomes. To address this objective, applicants should propose research studies that will: (1) deepen our understanding of which aspects of social environments affect health outcomes for women and men at different stages of the lifecourse and in different social, economic, geographic, racial and ethnic sub-populations; (2) lead to a clearer understanding of mechanisms through which social environments have such effects; or (3) improve measurement methods and/or contribute to advances in analytic methods used in the study of social environments and health. Mechanism of Support. This FOA will utilize the R01 award mechanism. Funds Available and Anticipated Number of Awards. The NIH will commit approximately $5 million to this funding initiative in 2011, allowing the support of 8-9 new R01 applications, for a total of approximately $24 million over the next 5 years.

Purpose. The National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to support studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). Recent clinical studies indicate that over 50% of HIV-infected patients manifest HAND despite receiving HAART. The focus of this initiative is to encourage studies to discover novel genetic paradigms that may account for the interactions between the virus, the host, and the therapeutic drugs in the central nervous system (CNS) that result in the pathogenesis, progression, and clinical manifestations of HAND. The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, exome sequencing, and systems biology) to identify and validate (including in vitro models, animal models, and human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged. Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental Grant (R21) award mechanism and runs in parallel with an FOA of identical scientific scope, MH-11-020, which encourages applications under the Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. The NIMH and NINDS intend to commit approximately $2.0 million and $1.0 million respectively in FY 2011 to fund awards in response to the FOA and the companion announcement.

Purpose. The National Institute of Mental Health (NIMH) and The National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to support studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). Recent clinical studies indicate that over 50% of HIV-infected patients manifest HAND despite receiving HAART. The focus of this initiative is to encourage studies to discover novel genetic paradigms that may account for the interactions between the virus, the host, and the therapeutic drugs in the central nervous system (CNS) that result in the pathogenesis, progression, and clinical manifestations of HAND. The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, exome sequencing, and systems biology) to identify and validate (including in vitro models, animal models, and human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, MH-11-021, which encourages applications under the Exploratory/Developmental Grant (R21) award mechanism. Funds Available and Anticipated Number of Awards. NIMH has set aside a total of $2.0 million in FY 2011 and NINDS a total of $1.0 million for this FOA and the companion announcement. It is anticipated that 5-7 R01 awards will be funded.