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The purpose of this funding opportunity announcement (FOA), issued by NINDS, is to invite applications to participate as a Data Coordinating Center in the Network for Excellence in Neuroscience Clinical Trials. This clinical research network will develop and conduct multiple, scientifically sound, possibly biomarker-informed exploratory clinical trials evaluating the most promising therapies, whether from academic, foundation or industry discoveries.Examples include Phase 2 clinical trials and clinical research studies aimed at validating biomarkers and clinical outcomes in preparation for clinical trials. The network will provide a robust, standardized, and accessible infrastructure to facilitate rapid development and implementation of protocols in neurological disorders affecting adult and/or pediatric populations. While the network will not be specific to one disease, it will have the capacity to coordinate a cadre of specialist investigators to implement studies efficiently in response to disease-specific opportunities. This FOA solicits applications for the Data Coordinating Center (DCC). Separate FOAs solicit applications for the Clinical Sites and the Clinical Coordinating Center (insert links to RFA-NS-008 and RFA-NS-009).

The purpose of the NIH Summer Research Experience Program (referred to as the Summer Research Program) is to provide a high quality research experience for high school and college students and for science teachers during the summer academic break. The NIH expects that such programs will: help attract young students to careers in science; provide opportunities for college students to gain valuable research experience to help prepare them for graduate school; and enhance the skills of science teachers and enable them to more effectively communicate the nature of the scientific process to their students. The programs would also contribute to enhancing overall science literacy. Summer Research Programs that expand and complement existing summer educational and training programs are encouraged. Not all participating Institutes and Centers (ICs) support all aspects of this program. Therefore, prospective applicants should contact staff at the relevant IC (see Section VII) to discuss their proposed program.

This NIH Funding Opportunity Announcement (FOA), issued by the NIH Basic Behavioral and Social Science Opportunity Network [OppNet] solicits applications for short-term mentored career development (K18) awards in the basic behavioral and social sciences research (b-BSSR) from three months to one year in duration. The program targets established, mid-career and senior investigators, to support their development of research capability in b-BSSR. Two categories of candidates are targeted: (a) biomedical or clinical researchers with little experience in basic behavioral and social sciences research who seek training with a well established b-BSSR investigator in order to explore the introduction of b-BSSR into their research programs; and (b) investigators in the basic or applied behavioral and social sciences who wish to build new components or domains of basic-BSSR into their research programs. The intent of this FOA is to provide candidates with protected time to achieve a shift in the focus of their research direction in the basic behavioral and social sciences, or to substantially enrich a current b-BSSR research program through the introduction of tools, theories or approaches from another discipline or area of science; it is not intended as a substitute for research project support. This FOA is sponsored by the National Institutes of Health (NIH) Basic Behavioral and Social Science Opportunity Network (OppNet). OppNet strongly encourages investigators to consult NIH-OBSSRs definitions related to b-BSSR for OppNet-related FOAs.

This FOA issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), encourages Research Project Grant (R01) applications from institutions/organizations that propose to develop, validate, and/or calibrate informative outcome measures for use in clinical trials for individuals with intellectual and developmental disabilities (IDD). This funding opportunity will address a significant need in the field, one that is especially apparent in efforts to develop pharmacological treatments for these populations. This solicitation will focus ongoing clinical and translational research on a neglected area essential for therapy and pharmacological treatment development. Potential applicants may be interested in FOA (PAR-11-038) Preclinical Research on Model Organisms to Predict Treatment Outcomes for Disorders Associated with Intellectual and Developmental Disabilities (R01) issued simultaneously with this FOA.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage linked cooperative agreement (U01) applications from large, multidisciplinary groups of investigators to accelerate the rate of progress in identifying the genetic factors that contribute to epilepsy syndromes. Linked applications may include an administrative core, a genetics core, and specific scientific projects proposed for the initial performance period of the Center without Walls.

This Funding Opportunity Announcement (FOA), the Fogarty International Research Collaboration Basic Biomedical (FIRCA-BB) Research Award facilitates collaborative basic biomedical research between scientists supported by the National Institutes of Health (NIH) and investigators in low-and middle-income countries (LMIC). Special consideration will be given to proposed research that addresses significant global health problems, (particularly those of high relevance to a LMIC country or region) and that includes research capacity building as a major aim of the proposed project.

This FOA issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, encourages Research Project Grant (R01) applications from institutions/ organizations addressing preclinical research in model organisms of neurodevelopmental disorders. Applications responsive to this FOA will propose to develop, validate, and/or calibrate outcome measures, surrogate markers, and biomarkers in model organisms that can inform and effectively translate to human clinical trials for individuals with intellectual and developmental disabilities (IDD). In addition, applications may propose to conduct rigorous, controlled and standardized preclinical animal trials designed for safety, toxicity, and efficacy prediction or to perform an independent validation of efficacy in animals prior to human clinical trials. The goal of this FOA is to accelerate and improve the preclinical testing of candidate treatments and therapeutic compounds in order to move promising new drug therapies into clinical trials. Potential applicants may be interested in the FOA Outcome measures for use in treatment trials of individuals with intellectual and developmental disabilities issued simultaneously with this FOA.

Purpose. This FOA, issued by NINDS and NIDDK, promotes new interdisciplinary collaborations by researchers in neuroscience and in diabetes/metabolism to further understanding of the mechanisms by which the CNS controls glucose levels and the consequences to the CNS of derangements in these mechanisms. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. A maximum of $750,000 in first year direct costs is available with the anticipation that two to three new R01 awards will be made per year for the 3-year duration of this FOA. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received.

Purpose. Biomedical research laboratories increasingly undertake a software development project to solve a problem of interest specifically related to that laboratory. These software packages sometimes become useful to a much broader community of users that can include translational and clinical researchers. The goal of this program announcement is to support the continued development, maintenance, testing and evaluation of existing software. The proposed work should apply best practices and proven methods for software design, construction, and implementation to extend the applicability of existing biomedical informatics/computational biology software to a broader biomedical research community. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

This Funding Opportunity Announcement (FOA) encourages grant applications proposing the conduct of innovative, collaborative research and research training projects, between High Income country (HIC) and low- to middle-income country (LMIC) scientists, on nervous system function and disorders throughout life, relevant to LMICs. The collaborative research programs are expected to contribute to the long-term goals of building sustainable research capacity in LMICs to address nervous system development, function and impairment throughout life and to lead to diagnostics, treatment and prevention strategies.