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CIDR high-throughput genotyping, sequencing and supporting statistical genetics services are designed to aid the identification of genes that contribute to human health and disease. The services provided through CIDR focus primarily on needs that cant be readily handled by individual investigator laboratories.CIDR provides the most up-to-date platforms and services. This is an NIH-wide initiative that is managed by NHGRI.Information about the current services offered can be accessed via: http://www.cidr.jhmi.edu.

The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for a limited competition Funding Opportunity Announcement (FOA) utilizing a Cooperative Agreement (U24) to provide continuing support for consortia originally funded through the American Recovery and Reinvestment Act of 2009 (ARRA) to develop well characterized, broadly available induced pluripotent stem cell (iPSC) resources for neurodegenerative diseases. A primary goal of this new initiative is to facilitate the scientific evaluation of iPSC resources for drug discovery purposes and to increase the number of lines, types of mutations, reporter modifications, maintenance and differentiation protocols and cell line characterization that are broadly available to the community as research resources. This Initiative is intended to be a partnership with government, non-government organizations and pharmaceutical companies interested in advancing drug discovery efforts for neurodegenerative diseases.

The purpose of the NIH Independent Scientist Award (K02) is to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research. The K02 award provides three, four, or five years of salary support and protected time for newly independent (see IC provisions) scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. Each independent scientist career award program must be tailored to meet the individual needs of the candidate. Prospective candidates are encouraged to contact the relevant Institute or Center (IC) staff for IC-specific programmatic and budgetary information: Table of IC-Specific Information, Requirements and Staff Contacts.

The purpose of the NIH Midcareer Investigator Award in Patient-Oriented Research (K24) is to provide support to mid-career health-professional doctorates or equivalent who are typically at the Associate Professor level or the equivalent (see Section III. Eligible Individuals) for protected time to devote to patient-oriented research (POR) and to act as research mentors primarily for clinical residents, clinical fellows and/or junior clinical faculty. Prospective candidates are encouraged to contact the relevant NIH staff for IC-specific programmatic and budgetary information: Table of IC-Specific Information, Requirements and Staff Contacts.

The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and protected time to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research. Individuals with a clinical doctoral degree interested in pursuing a career in patient-oriented research should refer to the NIH Mentored Patient-Oriented Research Career Development Award (Parent K23). Prospective candidates are encouraged to contact the relevant NIH staff for IC-specific programmatic and budgetary information: Table of IC-Specific Information, Requirements and Staff Contacts..

The primary purpose of the Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented NIH-supported independent investigators. The program is designed to facilitate a timely transition from a mentored postdoctoral research position to a stable independent research position with independent NIH or other independent research support at an earlier stage than is currently the norm. Prospective candidates are encouraged to contact the relevant NIH staff for IC-specific programmatic and budgetary information: Table of IC-Specific Information, Requirements and Staff Contacts.

The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research. Individuals with a clinical degree who are interested in further career development in biomedical research that is not patient-oriented should refer to the Mentored Clinical Scientist Career Development (Parent K08) Award. Prospective candidates are encouraged to contact the relevant NIH staff for IC-specific programmatic and budgetary information: Table of IC-Specific Information, Requirements and Staff Contacts.

The National Institute of Mental Health (NIMH), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS) invite research grant applications focused on elucidating the mechanisms of HIV-associated neuropathogenesis in the context of aging, chronic infection with HIV, and long term exposure to Highly Active Antiretroviral Therapy (HAART). The neuropathogenic mechanisms of HIV-Associated Neurocognitive Disorders (HAND) may be distinct in the aging HIV-infected populations given the potential interactions between aging associated events, HIV-associated neurodegenerative processes, and exposure to HAART. Understanding the pathogenesis of HAND in HIV-infected individuals over 50 years of age, in light of potential interactions with HAART, neurodegenerative diseases, and aging-related co-morbid conditions are the focus of this announcement. Applications ranging from basic research to clinical diagnosis and treatment in domestic and international settings are of interest. Multidisciplinary research teams and collaborative alliances are encouraged, but not required.

The National Institute of Mental Health (NIMH), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS) invite research grant applications focused on elucidating the mechanisms of HIV-associated neuropathogenesis in the context of aging, chronic infection with HIV, and long term exposure to Highly Active Antiretroviral Therapy (HAART). The neuropathogenic mechanisms of HIV-Associated Neurocognitive Disorders (HAND) may be distinct in the aging HIV-infected populations given the potential interactions between aging associated events, HIV-associated neurodegenerative processes, and exposure to HAART. Understanding the pathogenesis of HAND in HIV-infected individuals over 50 years of age, in light of potential interactions with HAART, neurodegenerative diseases, and aging-related co-morbid conditions are the focus of this announcement. Applications ranging from basic research to clinical diagnosis and treatment in domestic and international settings are of interest. Multidisciplinary research teams and collaborative alliances are encouraged, but not required.

The purpose of this limited competition Funding Opportunity Announcement (FOA) is to provide an opportunity for the NINDS American Recovery and Reinvestment Act (ARRA)-funded consortia to compete for another three years of participation in the Rare Diseases Clinical Research Network (RDCRN). The RDCRN is a collaborative and coordinated network of Clinical Research Consortia comprised of investigators and patient support groups committed to investigation of rare diseases working in partnership with the Data Management Coordinating Center to enhance communication and sharing of resources in a multidisciplinary approach. The RDCRN is focused on 1) the collection of clinical information to better define disease natural history and to develop biomarkers as well as new approaches to diagnosis, prevention, and treatment of rare diseases, and 2) training of new clinical investigators in rare diseases research.