Notice Availability Administrative Supplements NIH Grants Promote Implementation Research Brain Nervous System Disorders Low- Middle-Income Countries Notice Number: NOT-TW-19-003 Key Dates Release Date: April 03, 2019 Related Announcements PA-18-279 PA-18-280 RFA-MH-16-350 PAR-16-174 RFA-17-650 PAR-18-267 RFA-18-706 PAR-18-007 PA-18-363 PAR-17-001 PA-18-393 PA-18-394 PAR-18-717 Issued Fogarty International Center FIC) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to solicit administrative supplement applications implementation research/ research training existing awards brain nervous system related topics low- middle-income countries LMICs). One-year supplements active NIH neuro-related grants under eligible mechanisms, be requested. Eligible parent grants must focused neuro-health is used here denote prevention, diagnosis, treatment, rehabilitation neurological, neuropsychiatric, developmental, addiction behavioral disorders enhancing improving, cognitive, motor other neurological function. supplement request support pilot research research training projects activities related implementation science global neuro-health must based and within scope an existing grant the primary performance site an eligible LMIC. goal these projects and/or activities to help accelerate translation evidence policy practice effective interventions brain nervous system disorders within community population-level programs, services, strategies scale, within LMICs. supplement FOA Notice supports proposals activities including not limited to: 1) extension neuro-health research results through applications development targeted implementation research research capacity building LMICs 2) integration neuro-health related implementation research existing and/or planned health practice, programming policy. Proposals must: within scope the active parent award be research research-related activities the parent grant LMIC site. be currently focused primarily implementation research add implementation research, research training planning activities, expand current implementation science activities, a primary focus the supplement, within scope the program. Propose address or implementation research/ research capacity building objectives likely stimulate additional activity leading progress neuro-health related implementation research Address priority the IC issued parent award Background: the purposes this supplement request define implementation research application implementation science strategies research develop, test, adopt integrate evidence-based health interventions the context clinical community settings. gap between promise scientifically-proven health interventions brain neurological disorders their successful implementation standard care the real world persists. Implementation research the potential address challenge is critical determining to develop scale effective implementation evidence-based strategies address todays key global health problems. Implementation research studies should assume empirically-supported interventions be integrated any service setting applied any patient group population without attention local context, nor a unidirectional flow information e.g., publishing recommendation, trial, guideline) sufficient achieve practice policy change. Relevant intervention studies should develop knowledge base how" interventions integrated within real-world practice settings patient populations, will likely require than distribution information the interventions. Research models, theories conceptual frameworks the implementation process encouraged move away an exclusively top-down" approach a greater emphasis the resources local care settings the needs multiple stakeholders. main purpose these supplements to develop pilot implementation research projects activities extending global neuro-health research results the parent grant. goal these pilot projects and/or activities to help further develop accelerate application translation effective interventions brain neurological disorders medical/clinical, community population-level programs services LMICs. Proposed activities under supplement should and/or contribute the development the knowledge base effective scale of evidence-based interventions developed, adapted tested the local context. Implementation Science Objectives: Proposed research research training should host-country driven address questions implementation scientifically-proven interventions neuro-health. Where possible, within goal building the parent grant, includes research training related activities strengthen implementation research capacity. Implementation research goals address include: - Communication collaboration between researchers research end users program implementers, health practitioners, policy-makers); - Cost-effective, novel, innovative research methods demonstrate effective interventions be implemented brought scale; - Innovative methods the study implementation scale-up proven interventions achieve improved health outcomes; - Dissemination research findings, implementation scale-up proven health interventions neuro-health. - Using, testing evaluation strategies implement interventions related health promotion, prevention, screening, early detection, diagnosis, effective treatments proven clinical procedures guidelines integrated existing care systems neuro-health. Research/ research training also encouraged focuses the adoption, implementation sustainability evidence-based practices clinical community settings through studies on: - implementation multiple evidence-based practices meet complex needs patients diverse systems care; - systematic identification intervention components must modified most effective local adaptation evidence-based practices; - to influence organizational structure, climate, culture, processes enable dissemination implementation information the implementation effective interventions. Approaches implementation research/ research training include team science, community-based participatory research, action research related frameworks engage stakeholders end users throughout research process. in-country LMIC partners must clearly involved the supplement application. Proposed research/ research training related research activities should address synergies country public health plans and/or national health research priorities, where appropriate. Plans facilitate synergy should included part the supplement application. strategy include, example, letter the Ministry Health stating the neuro-health implementation research/ research training being developed be valuable develop evidence base the countrys policies programming. Specific Research Interests the FOA Sponsors: Participating NIH Institutes Centers ICs) provided specific statements interest this FOA below. Applicants obtain information research interests each the NIH participants this FOA their web sites through Scientific/Research contact listed this announcement. Fogarty International Center FIC) is interested supplement applications eligible neuro-health related R01 D43 FIC grants relevant the neuro-health implementation science research focus this Notice the FIC mission subject funds available). Parent grants their first year funding on extension not eligible FIC supplement funding under Notice. FIC Strategic plan
http://www.fic.nih.gov/About/Pages/Strategic-Plan.aspx) includes following relevant goals: 1) Stimulate innovation the development implementation technologies other locally-relevant solutions address global health problems; 2) Support research research training implementation science; National Institute Mental Health(NIMH) interested implementation questions facing LMICs their efforts expand access evidence-based mental health care, improve quality mental health care, and/or foster evidence-based policy program development mental health. Supplement applications considered relevant NIMH priorities under FOA include, are limited to, those propose to: Develop and/or validate implementation measures use mental health care across low-resource settings Identify test mechanisms system- provider-level change are causally associated quality care and/or therapeutic endpoints existing data model test causal relations among interventions, intervention targets, proximal distal clinical) outcomes Optimize uptake, effectiveness, quality mental health screening, assessment, intervention varied settings e.g., medical non-medical) Estimate costs integrating mental health care alternative delivery settings e.g., schools, chronic disease care, social services, justice settings) Evaluate dissemination strategies e.g., social marketing, technology-based, social media, peer network) increase awareness increase demand mental health screening, assessment, intervention services Assess implementation needs e.g., knowledge, skills, training, practice) health care providers HIV care treatment settings respect screening, assessment, care mental disorders Identify key tasks related mental health care are amenable management HIV care treatment teams, can used guide development implementation strategies integrating mental health care HIV care Develop test innovative implementation strategies training, supporting, supervising HIV care providers the effective delivery a basic package mental health services Build research capacity implementation science theory methods within LMICs and/or foster evidence-based policy program development mental health National Institute Neurological Disorders Stroke NINDS) interested supporting mechanistic, epidemiological, prevention, translational clinical research across spectrum neurological, neuromuscular, neuroinfectious neurovascular diseases disorders all ages. addition prevalent neurological disorders stroke, NINDS also interested supporting research capacity building areas rare neglected neurological diseases are relevant the collaborating LMICs NINDS Disorder Index
http://www.ninds.nih.gov/disorders/disorder_index.htm). NINDS like encourage development networks neuro-related topical disease-related areas e.g., stroke, epilepsy other high burden neurological disorders LMICs) linked existing programs resources LMICs e.g., MEPI, H3Africa, other NIH-funded projects) share capacity building activities conduct collaborative research. Under FOA, NINDS interested implementation research-related applications lay groundwork future clinical trials, such conducting surveys available patient populations, developing clinical trial protocols training materials, establishing trial infrastructure recruiting treating subjects collecting, receiving, storing distributing study drugs, processing data laboratory specimens. Applicants interested clinical trials neurological disorders within NINDS mission also referred NINDS clinical trial-specific funding announcements PAR-17-202 and PAR-17-122, PAR-17-314 ). National Institute Drug Abuse: The mission the National Institute Drug Abuse NIDA) to advance science the causes consequences drug and addiction to apply knowledge improve individual public health. NIDA International Program fosters international cooperative research the exchange information substance disorder researchers around globe. Although international researchers receive NIDA support through direct foreign grant, most international research supported through domestic grant a foreign component, where principal investigator a U.S. institution works a researcher another country. this FOA, eligible NIDA projects must conducting research a low and/or middle-income country LMIC) focuses neuro-health specific substance disorders. NIDA research projects seeking supplemental funds must a sufficiently developed program, practice intervention warrant incorporation pilot feasibility research implementation will lead a full-scale implementation study e.g., clinical trial), ultimately lead the adoption delivery interventions and/or services LMICs. Projects must include involvement in-country LMIC partners, outlined above the FOA. implementation research should demonstrate relevance the US. Research LMICs focused implementation science interest NIDA include, are limited to, following examples: Early stage implementation research capacity identify address organizational factors facilitate delivery evidence-based programs, practices interventions LMIC systems settings Feasibility research determine approaches delivering substance prevention treatment interventions rural and/or hard reach community settings, developed through collaborative partnerships Pilot feasibility research optimize interventions delivery LMIC systems settings Pilot research support use hybrid effectiveness-implementation designs LMICs Feasibility research develop models multi-level interventions e.g., target patients organizations) the adoption, implementation utilization evidence-based substance prevention treatment interventions Research develop cross-system collaborations e.g., health education) support delivery evidence-based prevention treatment interventions Investigators should submit applications responses the parent active administrative supplement PA, Administrative Supplements Existing NIH Grants Cooperative Agreements Parent Admin Supp Clinical Trial Optional):
https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html Supplements existing clinical trials allowed, addition a new clinical trial was a part the parent award not allowed. Before submitting supplement request, principal investigators strongly encouraged contact program officer, the program contact the Institute, Center Office supporting parent award discuss whether proposed supplement within scope the project the priorities the IC supporting parent award with any questions. Award Project Period be eligible, parent award must receive funds FY19 Oct. 1, 2018-Sept. 30, 2019) may be an extension period. request for year funding. Budget Supplement budget requests the one-year supplement cannot exceed 100,000 direct costs exclusive Facilities Administrative costs sub-contracts, 50% the direct costs the current parent award, whichever less. Requests must reflect actual needs the proposed project. Modular categorical budgets permitted. Eligible Individuals Program Director/Principal Investigator) Individual(s) submitting PD/PIs must hold active grant cooperative agreement an eligible neuro-health topic an eligible LMIC. supplements parent awards include multiple PDs/PIs, supplement be requested any all PDs/PIs accordance the existing leadership plan) submitted the awardee institution the parent award. Submitting Application additional information, the parent program announcement Administrative Supplements Existing NIH Grants Cooperative Agreements Parent Admin Supp Clinical Trial Optional) PA-18-591. part the application investigators should submit no than one-page abstract the proposed research shows relevance the existing grant implementation research/ research training goals articulates component(s) any IC-specific priorities the supplement addressing. Applicants should begin supplement application abstract stating: application being submitted PA-18-591 accordance NOT-TW-19-003." Page Limits: NIH consider supplements a Research Strategy of no than 6 pages, addition the abstract. Supplements should submitted electronically if allowed parent mechanism. addition, applicants strongly encouraged notify program contact the institute is supporting parent award list below) an application been submitted response this FOA facilitate efficient processing the request. Requests must received 5:00 PM Pacific Daylight Time P.D.T.) May 22, 2019. Institute, Center IC) Office-specific Instructions Review process IC conduct administrative reviews applications submitted their IC separately. Criteria: 1. the parent grant proposed supplement related neuro-health under definition the Notice) is work proposed within scope the active award? 2. the proposed implementation research-related work relevant the parent grant? well does enhance goals the parent grant? 3. Does work proposed address or of components listed under implementation research objectives? 4. Does work proposed scientific merit and/or increase implementation research capacity neuro-health? 5. the work likely stimulate additional activity leading progress implementation research? 6. Does work address priority the IC issued parent award applicable-see IC interests)? Inquiries Please direct inquiries to: Kathleen Michels, Ph.D. Fogarty International Center FIC) Telephone: 301-435-6031 Email:
michelsk@ficod.fic.nih.gov Beverly Pringle, Ph.D.National Institute Mental Health NIMH)Telephone: 301-443-3725Email:
bpringle@mail.nih.gov Belinda Sims, Ph.D.National Institute Drug Abuse NIDA)Telephone: 301-443-6504Email:
bsims@nida.nih.gov Dallas Anderson, Ph.D. National Institute Aging NIA) Telephone: 301-496-9350 Email:
andersda@nia.nih.gov Claudia Moy, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email:
MoyC@ninds.nih.gov