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Request Information RFI): NINDS Soliciting Input Enhancing Neuroscience Research Institutions Emerging Neuroscience Programs Notice Number: NOT-NS-19-059 Key Dates Release Date: 17, 2019 Response Date: June 17, 2019 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) Purpose recent years, explosion advanced neurotechnology led exciting new discoveries advances neuroscience. has also led a widening technology gap between leading neuroscience institutions, institutions emerging neuroscience programs. advances sophisticated approaches, technologies instrumentation neuroscience research increased need cost-effective access these resources through shared core facilities enhance quality science. purpose this Request Information RFI) to seek input the neuroscience community help define research resource needs institutions where growth neuroscience research programs limited the lack access specialized expertise, instruments services. Information Requested NINDS soliciting input researchers, institutional leadership, science administrators, research professional organizations, other interested members the neuroscience community, improving access research resources technology, instruments approaches) institutions emerging neuroscience programs. your response please indicate role the neuroscience community. you submitting response a researcher administrator/leader a research institution, please provide estimate the number program directors/principle investigators PI/PDs) engaged primarily neuroscience research your institution. you responding behalf a professional organization, please indicate name your organization. Please provide perspective the importance any all these research resources, their role fostering growth development emerging neuroscience research programs: Shared resource facility staff specialized expertise Basic shared resource facilities e.g., microscopy, animal behavior, etc.) Shared resource facilities advanced technologies e.g., Cryo EM, Light Sheet Microscopy, etc.) Training researchers specialized approaches techniques offered shared resource facilities please specify) to Submit Response Responses this RFI must submitted electronically. Responses be accepted through 06/17/2019. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted. Responses be shared publicly an NIH website. Please not include any personally identifiable other information you not wish make public. proprietary, classified, confidential, sensitive information should included your response. request for information planning purposes only should be construed a solicitation as obligation the part the United States Government. NIH not any awards based responses this RFI pay the preparation any information submitted for Government's of such information. Inquiries Please direct inquiries to: Timothy LaVaute, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: research.resources@ninds.nih.gov
Request Information: Seeking Feedback Research Priorities SCI 2020: Launching Decade Disruption Spinal Cord Injury SCI) Research Notice Number: NOT-NS-19-060 Key Dates Release Date: 14, 2019 Response Date: July 30, 2019 Related Announcements None Issued National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Fogarty International Center FIC) Purpose spinal cord injury SCI) research community experienced great advances discovery research, technology development, promising clinical interventions the past decade. build upon advances maximize benefit persons SCI, NIH hosted conference February 12-13, 2019 titled ldquo;SCI 2020: Launching Decade Disruption Spinal Cord Injury Research”. purpose the conference to bring together broad range stakeholders including researchers, clinicians health care professionals, individuals SCI, industry partners, regulators, funding agency representatives break down existing communication silos. participants asked critically evaluate state the science, assess areas technological community readiness, build collaborations could change trajectory research clinical options people SCI. Six primary sessions featured brief presentations recent scientific advances critical research questions the future. Facilitators audience participation encouraged identify opportunities areas collaboration. North American Spinal Cord Injury Consortium other public members provided personal context individuals living SCI defining future research priorities. five final breakout sessions, stakeholders discussed identified key gaps priorities SCI research the next decade. open sessions both days the conference be viewed at https://videocast.nih.gov/summary.asp?live=30194&bhcp=1 and https://videocast.nih.gov/summary.asp?live=30198&bhcp=1. Information Requested: NIH Institutes above soliciting comments suggestions the top priorities identified the five SCI 2020 breakout sessions summarized below. collated responses be shared the public will included a meeting summary document prepared collaboration the Spinal Cord Injury Model Systems Knowledge Translation Center https://msktc.org/about). NIH Institutes encourage input all interested stakeholders, including researchers, clinicians health care providers, individuals SCI, patient advocates health advocacy organizations, scientific professional organizations, federal agencies, well other interested members the public. Responders this RFI also encouraged provide input how research research capacity building the priority areas be adopted low resource settings including low- middle-income countries. Organizations strongly encouraged submit single response reflects views their organization membership. Optional: Please indicate you a researcher, clinician health care provider, individual SCI, patient advocate, and/or interested party. you submitting response behalf an organization, please indicate name your organization. SCI 2020: Research Priorities: Theme A: Improve care SCI patients the acute trauma setting Develop optimized approach infrastructure managing acute SCI: Establish evidence-based medical guidelines improve care SCI the time injury, including on-site stabilization, transportation admittance the ER trauma center. Establish evidence-based medical guidelines improve care SCI inpatient settings until discharge. Evaluate differences care during early period weeks months) after injury contribute long-term outcomes. Define provide specialty clinical expertise needed sites provide acute trauma care SCI. Improve multi-directional education among clinicians, patients, family, community peers. Align preclinical studies clinical conditions: Optimize of preclinical biomarkers outcome measures clinical relevance. Define clinically-feasible intervention window promising therapeutic approaches. Theme B: Accelerate research development therapies repair, plasticity improved functional recovery post-acute chronic SCI Develop use state the art technologies transform way study plasticity, circuits repair human SCI, well animal models. Expand fundamental knowledge the cells, circuits responses interventions inform innovative combinatorial repair approaches using cutting edge tools technologies. Define specificity requirements axonal growth, synapse formation, cell replacement, pathway activity and/or reconstruction circuits support recovery all stages post-injury. Optimize efficiency the of data standards data-sharing opportunities bench bedside bedside bench including unpublished data). Theme C: Improve evidence for, implementation of, functional recovery neuromodulation use-dependent plasticity Encourage longitudinal treatment studies study designs are informed outcomes high priority individuals chronic SCI. Understand mechanisms action characterize variables predict responsiveness neuromodulation interventions both early post-acute chronic conditions. Facilitate data sharing aggregation enable data science research can inform clinical care improve cost effectiveness interventions target recovery. Utilize input individuals SCI identify are acceptable risk/benefit ratios clinical trials modeled around the FDA’s Patient Engagement efforts). Theme D: Improve knowledge the full range health impacts chronic SCI Employ multi-site multi-disciplinary studies, SCI consumer community input, preclinical evidence use common data elements to: Understand impact behavioral, lifestyle, environmental factors reduce morbidity mortality across lifespan people SCI, a special emphasis nutrition metabolism, activity/exercise, and lean/fat mass a biomarker obesity. Promote safe efficient care recovery bowel, bladder sexual function; understand infection systemic inflammation impact functions individuals SCI. Understand biology impact SCI systemic health emphasis stressors effect immune function, role sensory autonomic regulation, physical mental health outcomes. Theme E: Improve functional recovery after SCI assistive technology Demonstrate assistive devices be used promote independence improve recovery after discharge. Incorporate user input, comparative effectiveness research, data sharing strategies establish robust evidence adoption assistive technologies. Improve reliability stability devices tissue interfaces lower barriers adoption improve embodiment. Develop approaches assistive devices adapt changes physical developmental needs, abilities, priorities the user over lifespan. to Submit Response: Responses this RFI must submitted electronically. Responses be accepted through July 30, 2019. Responses voluntary may submitted anonymously. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted. Responses be shared publicly an NIH website. Please not include any personally identifiable other information you not wish make public. proprietary, classified, confidential, sensitive information should included your response. request for information planning purposes only should be construed a solicitation as obligation the part the United States Government. NIH not any awards based responses this RFI pay the preparation any information submitted for Government's of such information. Inquiries Please direct inquiries to: Lyn Jakeman, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-827-5832 Email: lyn.jakeman@nih.gov Carol Taylor-Burds, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: carol.taylor-burds@nih.gov