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This Notice announces the availability of supplements to active grants which are intended to support collaborations that bring together expertise in biomedicine, data management, and artificial intelligence and machine learning (AI/ML) to make NIH-supported data useful and usable for AI/ML analytics. This initiative is aligned with the NIH Strategic Plan for Data Science, which describes actions aimed at modernizing the biomedical research data ecosystem and making data FAIR (Findable, Accessible, Interoperable, and Reusable) with high impact for open science. For the purposes of this Notice, AI/ML is inclusive of machine learning (ML), deep learning (DL), and neural networks (NN).

The purpose of this Notice is to inform interested applicants that the expiration date in PAR-18-205 " NIBIB Biomedical Technology Resource Centers (P41 Clinical Trials Optional)" will be extended by one receipt cycle (See changes in bold italics below). Part 1. Overview Key Dates Currently Reads: Expiration Date January 8, 2021 Modified to Read: Expiration Date May 8, 2021 All other aspects of this FOA remain unchanged.

This funding opportunity announcement (FOA) seeks competitive revisions for existing awards to support Phase II of the Rapid Acceleration of Diagnostics Underserved Populations (RADx-UP) initiative. These testing research projects will (1) expand the scope and reach of RADx-UP testing interventions to reduce COVID-19 disparities among underserved and vulnerable populations and (2) address scientific questions on interventions to increase access and uptake of COVID-19 testing given the increasing availability of SARS-CoV-2 vaccines. The funding for this initiative is provided from the American Rescue Plan Act of 2021.

This funding opportunity announcement (FOA) uses an emergency U01 mechanism to support Phase II of the Rapid Acceleration of Diagnostics Underserved Populations (RADx-UP) initiative. These two-year Testing Research Projects will (1) expand the scope and reach of RADx-UP testing interventions to reduce COVID-19 disparities among underserved and vulnerable populations and (2) address scientific questions on interventions to increase access and uptake of COVID-19 testing given the increasing availability of SARS-CoV-2 vaccines. The funding for this initiative is provided from the Paycheck Protection Program and Health Care Enhancement Act, 2020.

High rates and disparities of COVID-19 infection and mortality continue among underserved and vulnerable populations across the United States. The overarching goal of the Rapid Acceleration of Diagnostics for Underserved Populations (RADx-UP) initiative is to understand and ameliorate factors that have placed a disproportionate burden of the pandemic on underserved and/or vulnerable populations, specifically by implementing programs that expand the scope and reach of COVID-19 testing interventions to reduce these disparities. To address barriers to testing and vaccination, social, ethical, and behavioral research is urgently needed to inform related efforts. The purpose of this Phase II RADx-UP Funding Opportunity Announcement (FOA) is to expand research to understand and address the social, ethical, and behavioral implications (SEBI) of COVID-19 testing interventions among underserved and vulnerable populations. Proposed studies for Phase II are encouraged to move beyond descriptive health disparities research to focus on developing interventions and other actionable solutions in collaboration with community partners and stakeholders. The funding for this initiative is provided from the. American Rescue Plan Act of 2021.

The NIH Office of Data Science Strategy announces the availability of funds for Administrative Supplements to institutions with NIGMS-funded training (T32, T34), institutional career development (K12), or certain research education program (R25, see eligibility below) awards. The funds will support the development and implementation of curricular or training activities at the interface of information science, artificial intelligence and machine learning (AI/ML), and biomedical sciences to develop the competencies and skills needed to make biomedical data FAIR (Findable, Accessible, Interoperable, and Reusable) and AI/ML-ready. For the purposes of this Notice, AI/ML is inclusive of machine learning (ML), deep learning (DL), and neural networks (NN). See https://www.go-fair.org/fair-principles/ for a fuller description of FAIR principles.

This Notice of Special Interest (NOSI) provides an opportunity for researchers funded by the Helping to End Addiction Long-Term (HEAL) initiative to devote more time for mentorship activities. The NIH defines a mentor as experienced scientist who can help guide the research of junior investigators and challenge them to develop independence as researchers. The objectives of mentoring include to enhancing a mentees approach to scientific investigation, developing their critical thinking and communication skills and assisting with their progression the research community. Mentoring responsibilities involve helping junior investigators defining research goals, supporting the achievement of those goals, and discussing and evaluating progress throughout training. A mentor should provide constructive and timely feedback, support training, networking and professional development opportunities, and acknowledge a mentees contribution to research. The award is intended to provide protected time for established investigators supported by the HEAL Initiative to simultaneously provide mentoring to junior investigators. The supplement is intended for investigators (principal investigators or co-investigators) who have a record of supervising and mentoring clinical pain researchers. The NIH HEAL Initiative is a trans-agency effort to speed scientific solutions to stem the national opioid public health crisis through understanding, managing, and treating pain and improving treatment for opioid use disorder and overdose.

(Reissue of PAR-18-486) The purpose of the NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01) is to diversify the pool of independent neuroscience research investigators by providing junior faculty with research cost support, protected research time and career stage appropriate professional development mentorship in neuroscience research. Individuals from backgrounds underrepresented in biomedical research are eligible for support under this award if they have doctoral research degrees (Ph.D. or equivalent) and are in the first 3 years of a faculty tenure track or equivalent position at the time of application. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development. NINDS will only accept applications to this FOA that propose human mechanistic trials/studies that meet NIH's definition of a clinical trial and that fall within the NINDS research priorities. Applicants are strongly advised to consult with NINDS program staff prior to submitting an application with human subjects to determine the appropriate funding opportunity.

(Reissue of PAR-18-490) The purpose of the NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01) is to diversify the pool of independent neuroscience research investigators by providing junior faculty with research cost support, protected research time and career stage appropriate professional development mentorship in neuroscience research. Individuals from backgrounds underrepresented in biomedical research are eligible for support under this award if they have doctoral research degrees (Ph.D. or equivalent) and are in the first 3 years of a faculty tenure track or equivalent position at the time of application. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.

This Funding Opportunity Announcement (FOA) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support establishment of facilities at minority-serving institutions (MSIs) and Institutional Development Award (IDeA)-eligible institutions for scaled production and distribution of brain cell type-specific access and manipulation reagents. Reagents will be initially developed in pilot resource projects for brain cell type-specific access and manipulation across vertebrate species from the BRAIN Initiative Armamentarium project. Awardees under this FOA will work with the other Armamentarium awardees to manufacture and distribute the resources for use throughout the neuroscience community. It is envisioned that the awardees will work both with the Armamentarium community as well as with the neuroscience research community to optimize the use of new reagents. The types of reagents to be produced and distributed could include but are not limited to viral vectors, nucleic acid constructs, and nanoparticles designed for selective access to and manipulation of brain cell types. Such reagents will enable neuroscientists to probe circuit function with high precision in experimental animals and ex vivo human tissue and cells. Facilities are needed to contribute to the production and distribution of BRAIN Initiative Armamentarium project reagents broadly to neuroscience users.