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This Funding Opportunity Announcement (FOA), issued as part of the NIH Basic Behavioral and Social Sciences Opportunity Network (OppNet), encourages revision applications to incorporate basic research on behavioral and social mechanisms underlying stigma into active R01 research projects. For this initiative, projects may focus on stigma processes and mechanisms from the perspective of stigmatized individuals or groups and/or of individuals or groups holding stigmatizing beliefs. Projects may examine stigma in the context of specific health conditions; however, the focus of the work must be on the underlying mechanisms of stigma rather than on condition-specific manifestations of stigma.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) research grant applications to develop next-generation tools that distinguish heterogeneous states among cells and have commercial potential. Applications should define the current state of technology as a benchmark against which the new tool(s) will be measured. Applications should also propose proof-of-concept testing of the tool(s) in a complex biological tissue or living organism. The new tools should provide substantially increased sensitivity, selectivity, spatiotemporal resolution, scalability or non-destructive analysis of multiple global or functional measures of single cells. These novel technologies will aid in obtaining a fine-grained, integrative and dynamic view of heterogeneous cellular states/classes and will provide innovative platforms to transform research into the cellular basis of diseases.

The initiative will support a multicenter, systematic and comprehensive investigation of the neuropathology of Chronic Traumatic Encephalopathy and the delayed effects of traumatic brain injury using postmortem biospecimens, and histological and neuroimaging tools as a foundation for future studies to develop in vivo diagnostics.

This initiative will support pilot projects on sports-related traumatic brain injury and spinal cord injury.

This initiative will support pilot projects on sports-related traumatic brain injury and spinal cord injury.

This FOA solicits applications for the Lasker Clinical Research Scholars Program for the purpose of supporting the research activities during the early stage careers of independent clinical researchers. The program offers the opportunity for a unique bridge between the NIH intramural and extramural research communities and contains two phases.In the first phase, Lasker scholars will receive appointments for up to 5-7 years as tenure-track investigators within the NIH Intramural Research Program with independent research budgets.In the second phase, successful scholars will be eligible to apply for up to 5 years of NIH support for their research at an extramural research facility; or, the scholar can be considered to remain as an investigator within the intramural program.

The purpose of this funding opportunity announcement is to encourage collaborations between the life and physical sciences that: 1) apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and 2) integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods and techniques for a specific research or clinical problem in basic, translational, or clinical science and practice. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research and is appropriate for small teams applying an integrative approach that can increase our understanding of and solve problems in biological, clinical or translational science.

This funding opportunity announcement (FOA), issued by the NIH Basic Behavioral & Social Science Opportunity Network (OppNet), invites applications for short-term mentored career enhancement (K18) awards in basic behavioral and social sciences research (b-BSSR). This funding mechanism will support development of research capability in b-BSSR, with specific emphasis on cross-training and establishing collaborations between researchers with expertise in animal models of basic behavioral and social processes and those studying similar or related processes in human subjects. Basic research using any non-human species or with human subjects in laboratory- or field-based settings is appropriate for this FOA. Eligible candidates for this K18 will be either: (a) scientists conducting b-BSSR in animal models who seek training in the study of similar or related behavioral or social processes in humans; or (b) investigators conducting b-BSSR in human subjects who seek training in the study of similar or related processes in animal models. Candidates may be at any rank or level of research/academic development beyond three years of postdoctoral experience.

The purpose of this individual predoctoral research training fellowship is to provide support for promising doctoral candidates who are enrolled in combined MD-PhD programs, who will be performing dissertation research and training in scientific health-related fields relevant to the mission of the National Institute of Neurological Disorders and Stroke.

The purpose of this funding opportunity announcement (FOA) is to invite applications to participate as a National Clinical Coordinating Center for the NINDS Stroke Trials Network. The primary goal of this network is to maximize efficiencies to develop, promote and conduct high-quality, multi-site exploratory phase 1, 2 and confirmatory phase 3 clinical trials focused on key interventions, as well as biomarker-validation studies that are immediately preparatory to trials, in stroke prevention, treatment, and recovery with the objective to have a balanced portfolio between all three approaches. The network will include multiple regional coordinating stroke centers with strong collaborative relationships between vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology that is coordinated through separate National Clinical Coordinating and Data Management Centers. Efficiency will be encouraged through the use of master trial agreements and a central IRB. Clinical and basic scientists at the regional coordinating stroke centers will contribute to the development of network clinical trial applications for peer review, as well as planning for execution of NINDS-funded clinical trial applications from outside of the network, including trials that result from Collaborative Research and Development Agreements between the NINDS and Industry partners. The Network will also be uniquely poised to rapidly collaborate with other existing networks, such as the NINDS Neurological Emergencies Treatment Trials Network (NETT) or international consortia to conduct larger, definitive trials of promising interventions for the treatment of stroke.