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Notice Intent Publish Funding Opportunity Announcement NINDS StrokeNet Regional Coordinating Stroke Centers U24) Notice Number: NOT-NS-17-019 Key Dates Release Date: March 20, 2017 Estimated Publication Date Announcement: 2017   First Estimated Application Due Date: September 2017 Earliest Estimated Award Date: July 2018 Earliest Estimated Start Date: September 2018 Related Announcements PAR-17-276 Issued National Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS), intends issue Funding Announcement FOA) solicit applications NINDS StrokeNet Regional Coordinating Centers U24) participate StrokeNet clinical recruitment centers during next 5 years the program. goal this existing network www.nihstrokenet.org) to maximize efficiencies develop, promote conduct high-quality, multi-site clinical trials focused key interventions stroke prevention, treatment, recovery the objective have balanced portfolio between three approaches.  Exploratory phase 1/2 confirmatory phase 3 clinical trials well biomarker-validation studies are immediately preparatory trials be coordinated through separate National Clinical Coordinating Data Management Centers.  Efficiency fostered through use master trial agreements a central IRB.  Leaders drawn both clinical basic stroke science communities the sites contribute the development network clinical trial proposals peer review, well planning execution proposals coming outside the network, including trials result a Collaborative Research Development Agreement CRADA) between NINDS an Industry partner.  Network also uniquely poised rapidly collaborate other existing networks International Consortia conduct larger, definitive trials promising interventions the treatment stroke. Notice being provided allow potential applicants sufficient time develop meaningful collaborations competitive research programs.  FOA expected be published Summer 2017 an expected receipt date October 2017. FOA utilize U24 activity code. Details the planned FOA provided below. Research Initiative Details NINDS Stroke Trials Network utilize Cooperative Agreements U24) support clinical recruiting sites the Stroke Trials Network up 5 years.  funded site the network have access stroke patients have demonstrated ability enroll patients stroke trials.  site also strong collaborative relationships between Vascular Neurology, Emergency Medicine, Interventional Neuroradiology, Neurosurgery, NeuroIntensive care, Neuroimaging, Stroke Rehabilitation, Pediatric Neurology order ensure commitment offer every eligible patient opportunity participate a trial conducted through Network.  addition, network sites include stroke research training program.  network sites be committed increase value clinical research data through aggressive data sharing plan. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Scott Janis, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301) 496-9135 Email: janiss@ninds.nih.gov  

Notice Requirement Predoctoral T32 Training Programs Formerly Supported NIGMS Intend apply the Jointly Sponsored Predoctoral Training Program the Neurosciences JSPTPN) Notice Number: NOT-NS-17-018 Key Dates Release Date: March 8, 2017 Related Announcements NOT-GM-14-104 Issued National Institute Neurological Disorders Stroke NINDS) National Institute General Medical Sciences NIGMS) Purpose described NOT-GM-14-104 NIGMS no longer accepting applications the neurosciences research area under Systems Integrated Biology SIB) Predoctoral Training Program.  Early stage neuroscience training programs are currently supported NIGMS encouraged apply the Jointly Sponsored Predoctoral Training Program the Neurosciences JSPTPN, PAR-17-096) NIH funding.  purpose this Notice to inform institutions neuroscience training programs were previously are currently supported the SIB Program they must submit new Type 1) applications response PAR-17-096. Applications submitted renewal applications Type 2) any program currently formerly supported the JSPTPN FOA not accepted review. Inquiries Please direct inquiries to: Letitia Weigand, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: letitia.weigand@nih.gov nbsp;

Notice Date Informational Webinar PAR-16-219 NINDS Faculty Development Award Promote Diversity Neuroscience Research K01)" Notice Number: NOT-NS-17-017 Key Dates Release Date:   February 10, 2017 Related Announcements PAR-16-219 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants mentors to the NINDS Faculty Development Award Promote Diversity Neuroscience Research K01) the date an upcoming webinar preparing applications this mechanism. webinar optional not required submission PAR-16-219. Webinar Information nbsp; You Need Know the NINDS Diversity Faculty Development K01 Award: Tips Preparing Application March 22, 2017, 2:00 - 3:00 p.m. Eastern Time Learn the NINDS K01 diversity faculty development award successful applicants a reviewer these mechanisms. webinar take through process putting together application the NINDS Faculty Development Award Promote Diversity Neuroscience Research K01) the from writing application anticipating responding reviewer's comments. Hear two K01 awardees how crafted applications, learn a reviewer common mistakes helpful tips. webinar intended potential applicants mentors NINDS diversity K01 grants. register the webinar, please to: https://nih.webex.com/nih/onstage/g.php?MTID=eb57f85ff7f36b4aa3334f4b98…. registration link available the bottom the page. Inquiries Please direct inquiries to: Michelle Jones-London, PhD National Institute Neurological Disorders Stroke NINDS)  Telephone: 301-496-4188 Email: NINDSDiversityTraining@ninds.nih.gov nbsp;

Extension Expiration Date PAR-14-287 NINDS CREATE Bio Discovery Track: Optimization Preparation Development Biotechnology Products Biologics U44)" Notice Number: NOT-NS-17-012 Key Dates Release Date: February 6, 2017 Related Announcements PAR-14-287 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-14-287 quot;NINDS CREATE Bio Discovery Track: Optimization Preparation Development Biotechnology Products Biologics U44)" be extended one receipt cycle. additional non-AIDS application due date July 18, 2017, AIDS AIDS-related applications due date September 7, 2017 been added this FOA. FOA expires September 8, 2017. Key Dates table updated accordingly: Part 1. Overview Information Key Dates Application Due Date(s) October 21, 2014; February 11, 2015; August 11, 2015; February 11, 2016; August 11, 2016; February 8, 2017; July 18, 2017, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) January 7, 2015; 7, 2015; September 7, 2015; 7, 2016; September 7, 2016; May 7, 2017; September 7, 2017, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review February 2015; June 2015; November 2015; June 2016; November 2016; June 2017; November 2017 Advisory Council Review 2015; October 2015; January 2016; October 2016; January 2017; October 2017; January 2018 Earliest Start Date(s) July 2015 Expiration Date September 8, 2017 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D., National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: chris.boshoff@nih.gov nbsp;

Notice Extend Expiration Date PAR-14-208 NINDS Renewal Awards SBIR Phase II Grants Phase IIB) Exploratory Clinical Trials Clinical Research R44)" Notice Number: NOT-NS-17-015 Key Dates Release Date: February 6, 2017 Related Announcements PAR-14-208 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-14-208 quot;NINDS Renewal Awards SBIR Phase II Grants Phase IIB) Pre-Clinical Research R44)" be extended one receipt cycle.  additional application due date, September 5, 2017, been added this FOA.  FOA expires September 6, 2017. Key Dates Table updated accordingly: Part 1. Overview Information Key Dates Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date September 6, 2017 nbsp; other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov nbsp;

Extension Expiration Date PAR-14-288 NINDS CREATE Bio Development Track: Preclinical Early-phase Clinical Development Biotechnology Products Biologics UH2/UH3)" Notice Number: NOT-NS-17-013 Key Dates Release Date: February 6, 2017 Related Announcements PAR-14-288 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-14-288 quot;NINDS CREATE Bio Development Track: Preclinical Early-phase Clinical Development Biotechnology Products Biologics UH2/UH3)" be extended one receipt cycle. additional non-AIDS application due date July 18, 2017, AIDS AIDS-related applications due date September 7, 2017 been added this FOA. FOA expires September 8, 2017. Key Dates table updated accordingly: Part 1. Overview Information Key Dates Application Due Date(s) October 21, 2014; February 11, 2015; August 11, 2015; February 11, 2016; August 11, 2016; February 8, 2017; July 18, 2017, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) January 7, 2015; 7, 2015; September 7, 2015; 7, 2016; September 7, 2016; May 7, 2017; September 7, 2017, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review February 2015; June 2015; November 2015; June 2016; November 2016; June 2017; November 2017 Advisory Council Review 2015; October 2015; January 2016; October 2016; January 2017; October 2017; January 2018 Earliest Start Date(s) July 2015 Expiration Date September 8, 2017 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D., National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: chris.boshoff@nih.gov nbsp;

Notice Extend Expiration Date PAR-14-209 NINDS Renewal Awards SBIR Phase II Grants Phase IIB) Pre-Clinical Research R44)" Notice Number: NOT-NS-17-016 Key Dates Release Date: February 6, 2017 Related Announcements PAR-14-209 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-14-209 quot;NINDS Renewal Awards SBIR Phase II Grants Phase IIB) Pre-Clinical Research R44)" be extended one receipt cycle.  additional application due date, September 5, 2017, been added this FOA.  FOA expires September 6, 2017. Key Dates Table updated accordingly: Part 1. Overview Information Key Dates Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date September 6, 2017 nbsp; other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov nbsp;

Extension Expiration Date PAR-14-289 NINDS CREATE Bio Development Track: Preclinical Early-phase Clinical Development Biotechnology Products Biologics U44)" Notice Number: NOT-NS-17-014 Key Dates Release Date: February 6, 2017 Related Announcements PAR-14-289 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-14-289 NINDS CREATE Bio Development Track: Preclinical Early-phase Clinical Development Biotechnology Products Biologics U44)" be extended one receipt cycle. additional non-AIDS application due date July 18, 2017, AIDS AIDS-related applications due date September 7, 2017 been added this FOA FOA expires September 8, 2017. Key Dates table updated accordingly: Part 1. Overview Information Key Dates Application Due Date(s) October 21, 2014; February 11, 2015; August 11, 2015; February 11, 2016; August 11, 2016; February 8, 2017; July 18, 2017, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) January 7, 2015; 7, 2015; September 7, 2015; 7, 2016; September 7, 2016; May 7, 2017; September 7, 2017, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review February 2015; June 2015; November 2015; June 2016; November 2016; June 2017; November 2017 Advisory Council Review 2015; October 2015; January 2016; October 2016; January 2017; October 2017; January 2018 Earliest Start Date(s) July 2015 Expiration Date September 8, 2017 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D., National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: chris.boshoff@nih.gov  

Notice Extension Expiration Date PAR-14-286 NINDS CREATE Bio Discovery Track: Optimization Preparation Development Biotechnology Products Biologics U01)" Notice Number: NOT-NS-17-011 Key Dates Release Date: February 3, 2017 Related Announcements PAR-14-286 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-14-286 quot;NINDS CREATE Bio Discovery Track: Optimization Preparation Development Biotechnology Products Biologics U01)" be extended one receipt cycle. additional non-AIDS application due date July 18, 2017, AIDS AIDS-related applications due date September 7, 2017 been added this FOA. FOA expires September 8, 2017. Key Dates table updated accordingly: Part 1. Overview Information nbsp; Key Dates nbsp; Application Due Date(s) October 21, 2014; February 11, 2015; August 11, 2015; February 11, 2016; August 11, 2016; February 8, 2017; July 18, 2017, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) January 7, 2015; 7, 2015; September 7, 2015; 7, 2016; September 7, 2016; May 7, 2017; September 7, 2017, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review February 2015; June 2015; November 2015; June 2016; November 2016; June 2017; November 2017 Advisory Council Review 2015; October 2015; January 2016; October 2016; January 2017; October 2017; January 2018 Earliest Start Date(s) July 2015 Expiration Date September 8, 2017 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D., National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: chris.boshoff@nih.gov

Notice Reissuance PAR-16-106 Change Due Dates R21 Applications the Assessment Zika Virus ZIKV) Complications Notice Number: NOT-HD-16-036 Key Dates Release Date: December 14, 2016 Related Announcements NOT-HD-16-033 PAR-16-106     Issued Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Institute Allergy Infectious Diseases NIAID) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Dental Craniofacial Research NIDCR) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) Purpose Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), other NIH Institutes Centers ICs) listed above, announces PAR-16-106 quot;Rapid Assessment Zika Virus ZIKV) Complications R21)" being reissued. reissued FOA use standard application due dates, the timeframes review, council award dates now align standard NIH practices.  the reissuance the FOA, Zika-related R21 applications no longer accepted a rolling basis.  last day submit quot;rapid" R21 under PAR-16-106 be January 13, 2017.  After date, R21 applications be submitted the reissued FOA standard due dates. goal PAR-16-106 been respond quickly the public health emergency, reviewing applications rapidly, making timely awards support much needed projects.  a result this effort grants awarded support number highly meritorious projects were particularly urgent time-sensitive.  participating ICs) intend continue commitment supporting Zika research, applications no longer accepted a rolling basis. every NIH Institute Office had participated PAR-16-106 participate the re-issued FOA, there other FOAs support Zika projects related their research interests priorities.  example, PA-16-141 invites applications the quot;Development Anima Models Related Biological Materials Research R21).”  NOT-HL-16-466 lists FOAs addressing Zika virus related blood supply safety transfusion research. Zika-related FOAs be found searching NIH Guide Grants Contracts at: http://grants.nih.gov/funding/index.htm. addition, Zika-related applications also submitted response one the NIH-wide parent FOAs. Potential applicants strongly encouraged contact Scientific/Research staff before submitting application determine whether not proposed work within intended scope this program. Inquiries Please direct inquiries to: Nahida Chakhtoura MD, MsGH Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Telephone: 301-435-6872 Email: nahida.chakhtoura@nih.gov Julia L. Zehr, Ph. D. National Institute Mental Health NIMH) Telephone: 301-443-1617 Email: zehrj@mail.nih.gov Wong, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1431 Email:  wongm@ninds.nih.gov Lillian Shum, PhD National Institute Dental Craniofacial Research NIDCR) Telephone: 301-594-0618 Email:  ShumL@mail.nih.gov Mark Challberg, PhD National Institute Allergy Infectious Diseases NIAID) Phone: 301-496-7453 Email: MCHALLBERG@niaid.nih.gov George McKie, DVM, PhD National Eye Institute NEI) Telephone: 301-435-8152 Email: mckiegeo@nei.nih.gov Šeila Selimovic, Ph.D. National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-451-4577 Email:  Seila.Selimovic@nih.gov  Simone Glynn, M.D., M.P.H. National Heart, Lung, Blood Institute NHLBI) Telephone: 301-435-0065 Email: glynnsa@nhlbi.nih.gov Stephanie Murphy, V.M.D., Ph.D. Office Research Infrastructure Programs Telephone: 301-451-7818 Email: stephanie.murphy@nih.gov