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Notice Additional Due Date Additional Areas Focus Especially Interest” PAR-19-373 PAR-19-384, Research Biopsychosocial Factors Social Connectedness Isolation Health, Wellbeing, Illness, Recovery R01)" Notice Number: NOT-OD-20-103 Key Dates Release Date: 7, 2020 Related Announcements PAR-19-373 PAR-19-384 Issued NIH Basic Behavioral Social Science Opportunity Network OPPNET) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) National Center Complementary Integrative Health NCCIH) applications this funding opportunity announcement should fall within mission the Institutes/Centers. following NIH Offices co-fund applications assigned those Institutes/Centers. Office Behavioral Social Sciences Research OBSSR) Purpose purpose this Notice to add third due date” additional areas focus especially interest” PAR-19-373 PAR-19-384 Research Biopsychosocial Factors Social Connectedness Isolation Health, Wellbeing, Illness, Recovery R01 Clinical Trials Allowed/Basic Experimental Studies Humans Required),” between two current due dates, March 17, 2020 March 17, 2021. Part 1 both PARs, under Key Dates, additional application due date June 8, 2020, added. I. Part 1 Key Dates PAR-19-373 PAR-19-384 Currently Reads: Application Due Date(s): March 17, 2020; March 17, 2021 applications due 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due the listed date(s). Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. II. Part 1 Key Dates PAR-19-373 PAR-19-384 Modified this Notice) Read italics): Application Due Date(s): March 17, 2020; June 8, 2020; March 17, 2021 Scientific Merit Review: June 2020, October 2020, June 2021 applications due 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due the listed date(s). Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review: June 2020, October 2020; June 2021 Advisory Council Review: August 2020, January 2021, August 2021 III. Part 1 Key Dates PAR-19-373 PAR-19-384 Remain Unmodified: Earliest Start Date September 2020 Expiration Date March 18, 2021 Part 1 both PARs, under Part 2, Section I. Funding Opportunity Description, of Three areas focus especially interest OppNet participating NIH ICO’s include, are limited to, those listed below” appear as, 1. Effects social connectedness, connection, isolation across lifespan Affective cognitive function during aging process Contextual factors increase mitigate impact disruption isolation different developmental time points, e.g., Caregivers people dementia, severe illness, end-of-life Chronic illness limited mobility Perceived strength quality extant social connections Recent diagnosis a serious medical illness Sleep changes across lifespan e.g. during adolescence, early parenthood, menopause) Molecular markers mechanisms e.g., epigenetic modifications, gene expression, microbiome alterations, telomere attrition) associated changes social connectedness Neurobiological developmental trajectories Protective and/or risk factors associated isolation connection disruption different times development over lifespan e.g., adolescence, death mate/parent, middle-age males, onset serious medical diagnosis) Aggressive behaviors and/or risky sexual activity associated connection trajectories Mechanisms connectedness, connection, isolation Neurobiological factors Impact structure function the nervous system central, peripheral, autonomic) Impact neuroimmune neuroendocrine systems Impact neural systems associated basic affective, cognitive, social processes Importance inter-individual neural synchrony mediating moderating effects relationship trajectories Neurobiological biosignatures predict sensitivity connection disruption isolation Neurobiological processes could targets ameliorate negative effects disruption isolation Neurophysiological consequences disruption isolation substance disorders SUDs) mental illness Behavioral environmental factors consequences perceived isolation e.g., loneliness) and/or objective/observed isolation behavioral clinical outcomes adolescence adulthood Connections between social disruption/isolation specific populations and/or health/illness contexts, e.g., Sex/gender differences; sexual gender minorities Racial/ethnic differences, acculturation/bicultural adaptations contributions social integration versus isolation Autism, HIV, mental illness, recovery status, substance disorder Whether source connection disruption leads different processes outcomes E.g., Self-induced isolation versus isolation others, sense undesired loneliness vs. sought solitude Modified this Notice) Read italics): 1. Effects social connectedness, connection, isolation across lifespan Affective cognitive function during aging process Contextual factors increase mitigate impact disruption isolation different developmental time points, e.g., Caregivers people COVID-19, dementia, severe illness, end-of-life Chronic illness limited mobility Perceived strength quality extant social connections Recent diagnosis a serious medical illness including, not limited to, COVID-19 Sleep changes across lifespan e.g. during adolescence, early parenthood, menopause) Molecular markers mechanisms e.g., epigenetic modifications, gene expression, microbiome alterations, telomere attrition) associated changes social connectedness Neurobiological developmental trajectories Protective and/or risk factors associated isolation connection disruption different times development over lifespan e.g., adolescence, death mate/parent, middle-age males, onset serious medical diagnosis) Aggressive behaviors and/or risky sexual activity associated connection trajectories Mechanisms connectedness, connection, isolation Neurobiological factors Impact structure function the nervous system central, peripheral, autonomic) Impact neuroimmune neuroendocrine systems Impact neural systems associated basic affective, cognitive, social processes Importance inter-individual neural synchrony mediating moderating effects relationship trajectories Neurobiological biosignatures predict sensitivity connection disruption isolation Neurobiological processes could targets ameliorate negative effects disruption isolation Neurophysiological consequences disruption isolation substance disorders SUDs) mental illness Behavioral environmental factors consequences perceived isolation e.g., loneliness) and/or objective/observed isolation behavioral clinical outcomes adolescence adulthood Connections between social disruption/isolation specific populations and/or health/illness contexts, e.g., Sex/gender differences; sexual gender minorities Racial/ethnic differences, acculturation/bicultural adaptations contributions social integration versus isolation Autism, COVID-19, HIV, mental illness, recovery status, substance disorder Whether source connection disruption leads different processes outcomes E.g., Self-induced isolation versus isolation others, sense undesired loneliness vs. sought solitude E.g., Isolation the result preventing COVID-19 a household, preventing COVID-19 infection within household NOTE: other aspects these funding opportunity announcements PAR-19-373 PAR-19-384) remain unchanged. Inquiries Please direct inquiries to: William Elwood, PhD Office Behavioral Social Sciences Research OBSSR) Telephone: 301-402-0116 Email: william.elwood@nih.gov

Notice Change Key Dates PAR-18-721 Countermeasures Against Chemical Threats CounterACT) Exploratory/Developmental Projects Translational Research R21 Clinical Trial Allowed)" Notice Number: NOT-NS-20-064 Key Dates Release Date: 6, 2020 Related Announcements PAR-18-721 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-721 "Countermeasures Against Chemical Threats CounterACT) Exploratory/Developmental Projects Translational Research R21 Clinical Trial Allowed)." Specifically, last receipt date been changed June 30, 2020 the new expiration date this FOA be July 1, 2020. Changes the FOA shown below bold italics. Currently Reads: Part 1. Overview Information Key Dates: Application Due Date(s) 30, 2018; 28, 2019; 26, 2020, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Expiration Date 27, 2020 Modified Read: Part 1. Overview Information Key Dates: Application Due Date(s) 30, 2018; 28, 2019; June 30, 2020, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Expiration Date July 1, 2020 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Shardell Spriggs, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-443-8189 Email: shardell.spriggs@nih.gov

Notice Change Key Dates PAR-18-421 NINDS Program Project Grant P01 Clinical Trial Optional)" Notice Number: NOT-NS-20-071 Key Dates Release Date: 6, 2020 Related Announcements PAR-18-421 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-421 "NINDS Program Project Grant P01 Clinical Trial Optional)" changes shown below bold italics). Funding Opportunity Announcement been extended one additional council round. dates been modified add following New Application Due Date: January 25, 2021 AIDS Application Due Date May 7, 2021. Currently Reads: Part 1. Overview Information Key Dates Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2021 Modified Read: Part 1. Overview Information Key Dates Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: David Owens, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9248 Email: do47h@nih.gov

Notice Change Key Dates PAR-18-490 NINDS Faculty Development Award Promote Diversity Neuroscience Research K01 Independent Clinical Trial Allowed)" Notice Number: NOT-NS-20-067 Key Dates Release Date: 05, 2020 Related Announcements PAR-18-490 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-490 NINDS Faculty Development Award Promote Diversity Neuroscience Research K01 Independent Clinical Trial Allowed)". funding opportunity announcement been extended one additional council round. dates been modified add following New Application Due Date: February 12, 2021, Resubmission Date: March 12, 2021, AIDS application Due Date: 7, 2021. Currently Reads: Part 1. Overview Information Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2021 Modified Read: Part 1. Overview Information Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Michelle Jones-London, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-7966 Email: jonesmiche@ninds.nih.gov

Notice Change Key Dates PAR-18-486 NINDS Faculty Development Award Promote Diversity Neuroscience Research K01 Clinical Trial Required)" Notice Number: NOT-NS-20-068 Key Dates Release Date: 05, 2020 Related Announcements PAR-18-486 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-486 NINDS Faculty Development Award Promote Diversity Neuroscience Research K01 Clinical Trial Required)". funding opportunity announcement been extended one additional council round. dates been modified add following New Application Due Date: February 12, 2021, Resubmission Date: March 12, 2021, AIDS application Due Date: 7, 2021. Currently Reads: Part 1. Overview Information Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2021 Modified Read: Part 1. Overview Information Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Michelle Jones-London, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-7966 Email: jonesmiche@ninds.nih.gov

Notice Change Key Dates PAR-18-468 NINDS Advanced Postdoctoral Career Transition Award Promote Diversity Neuroscience Research K22-Clinical Trial Required)" Notice Number: NOT-NS-20-066 Key Dates Release Date: 05, 2020 Related Announcements PAR-18-468 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-468 NINDS Advanced Postdoctoral Career Transition Award Promote Diversity Neuroscience Research K22-Clinical Trial Required)". funding opportunity announcements been extended one additional council round. dates been modified add following New Application Due Date: February 12, 2021, Resubmission Date: March 12, 2021, AIDS application Due Date: May 7, 2021. Currently Reads: Part 1. Overview Information Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2021 Modified Read: Part 1. Overview Information Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Michelle Jones-London, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-7966 Email: jonesmiche@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement NINDS Exploratory Grant Program Parkinson's Disease Research P20- Clinical Trial Optional) P20 Clinical Trial Optional) Notice Number: NOT-NS-20-058 Key Dates Release Date: April 30, 2020 Estimated Publication Date Funding Opportunity Announcement: June 25, 2020 First Estimated Application Due Date: September 25, 2020 Earliest Estimated Award Date: July 01, 2021 Earliest Estimated Start Date: July 01, 2021 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends publish Funding Opportunity Announcement FOA) solicit applications an Exploratory Grant Program Parkinson's Disease Research. initiative request Exploratory Grantapplications the planning initiation collaborative efforts advance Parkinson's Disease PD) research. goal this program to formalize new interdisciplinary teams address critical gaps PD research establish foundation research discovery leading directly an NINDS Morris K. Udall Center Excellence PD Research P50) application. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. FOA expected be published Summer 2020 an expected application due date Autumn 2020. FOA utilize Exploratory Grant P20) activity code. Details the planned FOA provided below. Ressearch Initiative Details Notice encourages investigators expertise insights Parkinson's Disease PD) research begin consider applying this new FOA. initiative encourages PD research examining mechanisms underlie effects PD, well research designed improve translation existing knowledge strategies the prevention treatment PD. purpose this FOA Exploratory Grant P20) applications to support formation new interdisciplinary research teams innovative approaches address current challenges PD research. Through mechanism, NINDS seeks develop synergistic, proof-of-concept research efforts around investigator-defined thematic areas. overall goal to encourage formation new collaborative teams develop novel research plan, construct effective administrative organization, create standardized policies/procedures, gather rigorous preliminary data support novel ideas address urgent gaps emergent issues PD research. Successful Exploratory Grant activities should lead directly the submission a competitive NINDS Morris K. Udall Center Excellence (P50) application.? P20 application include Overall section, Administrative Core a minimum three research feasibility projects, of will led an Early Stage Investigator ESI). Research Cores not within scope. Exploratory Grant provide to years support. NINDS funding decisions focus primarily scientific merit, i.e., those applications are most likely make innovative contributions PD research that demonstrate potential submit Udall Center application the end the Exploratory Grant project period. Funding Information Estimated Total FundingThe NINDS intends commit to 1,800,000 FY2021. number awards contingent upon NIH appropriations the submission sufficiently meritorious applications. Expected Number Awards4 Estimated Award Ceiling Application budgets limited 300,000 direct costs per year exclusive facilities administrative costs subcontracts collaborating institutions). Budget requests should reflect actual needs the proposed project. Primary CFDA Numbers 93.853 Anticipated Eligible Organizations Private Institution Higher Education Public/State Controlled Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments Independent school districts Public housing authorities/Indian housing authorities Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time. Inquiries Please direct inquiries to: Beth-Anne Sieber, PhDNational Institute Neurological Disorders Stroke NINDS)(301) 496-5680 Beth-Anne.Sieber@nih.gov  

Notice Change Key Dates PAR-18-469 NINDS Advanced Postdoctoral Career Transition Award Promote Diversity Neuroscience Research K22-No Independent Clinical Trials)" Notice Number: NOT-NS-20-065 Key Dates Release Date: 01, 2020 Related Announcements PAR-18-469 - NINDS Advanced Postdoctoral Career Transition Award Promote Diversity Neuroscience Research K22-No Independent Clinical Trials) Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform interested applicants a change the Key Dates PAR-18-469 NINDS Advanced Postdoctoral Career Transition Award Promote Diversity Neuroscience Research K22-No Independent Clinical Trials)". funding opportunity announcements been extended one additional council round. dates been modified add following New Application Due Date: February 12, 2021, Resubmission Date: March 12, 2021, AIDS application Due Date: 7, 2021. Currently Reads: Part 1. Overview Information Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2021 Modified Read: Part 1. Overview Information Key Dates: Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Michelle Jones-London, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-7966 Email: jonesmiche@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research P50 Clinical Trial Optional) Notice Number: NOT-NS-20-057 Key Dates Release Date: April 30, 2020 Estimated Publication Date Funding Opportunity Announcement: June 25, 2020 First Estimated Application Due Date: September 25, 2020 Earliest Estimated Award Date: July 01, 2021Earliest Estimated Start Date: July 01, 2021 Related Announcements NOT-NS-20-058 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends publish Funding Opportunity Announcement FOA) solicit applications the Morris K. Udall Centers Excellence Parkinson's Disease Research program. overarching goal this program to establish network specialized Centers work collaboratively well independently define causes and discover improved treatments Parkinson’s disease PD). more immediate goal each Center to rapidly advance synergistic, interdisciplinary research programs while serving national leaders PD research. Udall Centers also serve local resources providing research career enhancement activities Center investigators periodic outreach the PD patient/advocacy community Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. FOA expected be published Summer 2020 an expected application due date Autumn 2020. FOA utilize P50 activity code. Details the planned FOA provided below. Ressearch Initiative Details Notice encourages investigators expertise insights this area Parkinson's Disease PD) begin consider applying this new FOA. Among areas research encouraged this initiative interdisciplinary research collaborations examining mechanisms underlie effects PD, well research designed improve translation existing knowledge strategies the prevention treatment PD. Applicants the Udall Centers program identify address overall research theme defines critical challenge PD research. Center theme, proposed research projects, associated cores inform etiology, pathogenesis treatment PD; investigations related synucleinopathies be included such directly address identified PD research challenge. Programmatic requirements this FOA include: three more Research Projects, including dedicated Udall Catalyst project led a junior investigator; Administrative Core; least integrated Research Core is essential and accelerates progress two more Research Projects; mission statement career enhancement Center investigators, a plan periodic outreach the local patient/advocacy community, including specific outreach events convey Center research advances. NINDS Udall Centers program prioritizes innovative integrative research significant potential discovery. Considerable synergy must evident among Center research projects cores, such the Center structure required successful completion the aims. Udall Center Director PD/PI) must a leader scientific research visionary leadership skills proven expertise the stewardship large-scale research programs; participating investigators must lead independent research programs, the exception the Udall Catalyst project investigator. Applicant institutions must provide solid evidence commitment the proposed Udall Center. Only new applications be accepted response this FOA. project period be five years. Funding decisions focus those applications most likely make significant contributions PD research, well those greatest potential collaborate effectively across Udall Centers program. Funding Information Estimated Total FundingThe NINDS intents commit to 6,750,000 total costs fiscal year FY) 2021. number awards contingent upon NIH appropriations the submission a sufficient number meritorious applications. Expected Number Awards3 Estimated Award Ceiling: Applicants request to 1,000,000 direct costs per year the following exception: applications containing translational project and/or clinical component i.e. clinical research project plus clinical core) request to 1,500,000 direct costs per year. Application budgets must justify reflect actual needs the proposed project. Primary CFDA Numbers98.853 Anticipated Eligible Organizations Public/State Controlled Institution Higher Education U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Independent school districts County governments Indian/Native American Tribal Government Federally Recognized) State Government For-Profit Organization than Small Business) Small Business Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Private Institution Higher Education Regional Organization Non-domestic non-U.S.) Entity Foreign Organization) Eligible Agencies the Federal Government Applications not being solicited this time. Inquiries Please direct inquiries to: Beth-Anne Sieber, PhDNational Institute Neurological Disorders Stroke NINDS)(301) 496-5680 Beth-Anne.Sieber@nih.gov nbsp; nbsp;

Notice Extension Expiration Date PAR-18-542 CREATE Bio Development Track: Nonclinical Early-Phase Clinical Development Biologics U01 Clinical Trial Optional)" Notice Number: NOT-NS-20-055 Key Dates Release Date: April 28, 2020 Related Announcements PAR-18-542 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform interested applicants the expiration date the Funding Opportunity Announcement FOA) PAR-18-542 CREATE Bio Development Track: Nonclinical Early-Phase Clinical Development Biologics U01 Clinical Trial Optional)" be extended. additional non-AIDS application due date February 12, 2021 AIDS AIDS-related applications due date May 7, 2021 been added this FOA. FOA expires May 8, 2021. Changes shown in bold italics below. Key Dates table updated accordingly: Part 1. Overview Information Key Dates Application Due Date(s) February 20, 2018, July 18, 2018, February 13, 2019, July 18, 2019, February 13, 2020, July 20, 2020), 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) 7, 2018; September 7, 2018; 7, 2019; September 7, 2019; 7, 2020; September 7, 2020, 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review June 2018; November 2018; June 2019; November 2019; June 2020; November 2020 Advisory Council Review October 2018; January 2019; October 2019; January 2020; October 2020; January 2021 Earliest Start Date December 2018 Expiration Date September 8, 2020 Modified Read: Application Due Date(s) February 20, 2018, July 18, 2018, February 13, 2019, July 18, 2019, February 13, 2020, July 20, 2020), and February 12, 2021 by 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) 7, 2018; September 7, 2018; 7, 2019; September 7, 2019; 7, 2020; September 7, 2020, May 7, 2021 by 5:00 PM local time applicant organization. All types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review June 2018; November 2018; June 2019; November 2019; June 2020; November 2020, June 2021 Advisory Council Review October 2018; January 2019; October 2019; January 2020; October 2020; January 2021, October 2021 Earliest Start Date December 2018 Expiration Date 8, 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Chris Boshoff, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: chris.boshoff@nih.gov