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The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA) intend to publish a Funding Opportunity Announcement (FOA) to solicit applications for basic and translational research on the impact of the microbiome gut-brain axis on Alzheimers Disease Related Dementias (ADRD). While there is growing evidence that the microbiome is an important factor that contributes to overall health and a variety of diseases and disorders, the role of intestinal microbiota dysfunction in specific ADRDs has not been adequately addressed. Furthermore, there is a need for more engagement of the ADRD research community to better understand the mechanistic relationship between the gut-brain axis and dementia-related diseases. This FOA will support mechanistic and early translational research focused on a more rigorous in-depth examination of the potential interactions between the gut microbiome and genetic and non-genetic molecular targets that influence ADRD. It is expected that these studies will address the clinical relevance of the gut microbiome on disease initiation, progression, or modification that will lead ultimately to better therapeutic interventions. This Notice is being provided to allow potential applicants sufficient time to develop integrated multidisciplinary collaborations and responsive projects. The FOA is expected to be published in Summer 2022 with an expected application due date in Fall 2022. This FOA will utilize the R01 (Clinical Trials Not Allowed) activity code.
The NIH Countermeasures Against Chemical Threats (CounterACT) program intends to publish a Funding Opportunity Announcement (FOA) to solicit applications for the discovery and early-stage development of safe and effective new and repurposed drug candidates to mitigate the health effects resulting from exposure to highly toxic chemical threats. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.