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The purpose of this notice is to inform applicants of a correction to section III. Eligibility Information for RFA-NS-22-038 "Research Program Award (R35 Clinical Trial Optional)".

This notice alerts applicants about an upcoming Pre-Application and Technical Assistance Webinar for RFA-MH-22-240 on September 22, 2022.

The purpose of this notice is to inform applicants of a clarification/change to the award project period for and the PHS 398 Research Plan for RFA-NS-21-010 "HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional).

The purpose of this notice is to clarify which Funding Opportunity Announcements (FOAs) NINDS will use to solicit applications in response to NOT-ES-22-006 "Notice of Special Interest (NOSI): Climate Change and Health". As stated in the NOSI, NINDS will accept applications from the following announcements: PA-20-184 Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required), PA-20-185 NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed), PA-20-196 NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required), PA-20-195 NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed).

The Office of Research Quality at the National Institute of Neurological Disorders and Stroke (NINDS) is issuing this notice to inform the extramural research community about updates to its initiative to develop an educational resource on the principles of rigorous research. The first set of applications have been funded from the Materials to Enhance Training in Experimental Rigor (METER) (UE5 Clinical Trial Not Allowed) funding opportunity, and two more receipt dates remain: October 11, 2022 and October 10, 2023. Because the mission of this initiative is to develop educational units on a variety of principles of rigorous research, NINDS would like to inform the scientific community about principles of rigorous research that remain high priority for potential development into educational units by METER applicants.

The purpose of this notice is to correct the key dates section of RFA-NS-22-040 "BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)".

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome (DS). This Notice of Special Interest (NOSI) announces NIH support for exploratory/developmental grant (R21) applications that are focused on community-based participatory research (CBPR) in DS to address health disparities and that meet programmatic objectives for the INCLUDE Project. Individuals with DS experience greater health disparities than the general population. These disparities in the DS community stem from disparities in healthcare services including receiving preventive services and access to quality care. Although the lifespan of individuals with DS has increased dramatically in the last few decades, the racial disparities in life expectancy are glaring. The median age of survival for Blacks and other racial groups falls way behind that of individuals with DS who are White although the prevalence of DS among all racial groups is about the same. Hence, it is important to understand the social determinants of heath (race, ethnicity, age, geography, and socioeconomic status) that lead to such disparities in the DS population. The Healthy People 2030 initiative [United States Department of Health and Human Services, 2030; https://health.gov/healthypeople] has also added Social Determinants of Health as a new objective to reduce health disparities and increase efforts to improve the health and well-being for all. To fully engage and understand the various factors (social, environmental, economic) contributing to health disparities in those with DS, we encourage collaboration and partnership among DS community members (those with DS, family members, self-advocates, and advocates) as well as various key stakeholders (scientists, clinicians, policy makers, educators) to propose projects that address these issues.

The purpose of this notice is to inform applicants of a change to the title to reflect NINR's participation in PAR-22-181 "NIDA, NIMH, and NINDS Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)".

This Notice informs potential applicants of the National Institute of Nursing Research (NINR) participation, effective immediately, in the funding opportunity announcement (FOA) PAR-22-181, NIDA, NIMH, and NINDS Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional).

Correcting total vs direct cost in the text.