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The purpose of this notice is to inform interested applicants of a change to the Key Dates and the specific research requirements for RFA-NS-19-001 "BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Clinical Trial Required)". The dates have been modified to add a new application due date of October 29, 2021. See changes below inbold italics.

The purpose of this notice is to inform interested applicants of a change to the Key Dates and the specific research requirements for RFA-NS-19-003 "BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)". The dates have been modified to add a new application due date of October 29, 2021. See changes below inbold italics.

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-019 "BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of May 4, 2021.

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-020 "BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of May 4, 2021.

Reissue of RFA-NS-20-010: The purpose of this funding opportunity announcement (FOA) is to support preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics to treat pain. The goal of the program is to accelerate the optimization and development of promising small molecule and biologic hits/leads towards clinical trials. Applicants must have a promising hit/lead, robust biological rationale for the intended approach, and identified assays for optimization of the agent. The scope of this program includes optimization and early development activities, IND-enabling studies, and assembly of Investigational New Drug (IND) application. This is a milestone-driven phased cooperative agreement program involving participation of NIH program staff in the development of the project plan and monitoring of research progress.

The purpose of this Notice is to extend RFA-MH-20-135, BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed)

The purpose of this Notice is to extend RFA-MH-19-135, BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-011 "Translational Neural Devices (UG3/UH3 Clinical Trial Required)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of February 22, 2021.

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-012 "Translational Neural Devices (U44 Clinical Trial Required)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of February 22, 2021.

The purpose of this notice is to inform applicants of a change to the Key Dates for RFA-NS-18-021 "BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Required)". This Funding Opportunity Announcement has been extended by one council round. The dates have been modified to add a New Application Due Date of February 22, 2021.