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Notice Intent Publish Request Applications the Morris K. Udall Centers Excellence Parkinson's Disease Research P50) Notice Number: NOT-NS-11-024 Key Dates Release Date: August 19, 2011   Issued National Institute Neurological Disorders Stroke NINDS) Purpose NINDS intends issue Funding Opportunity Announcement FOA) continue Morris K. Udall Centers Excellence Parkinson's Disease Research program http://www.ninds.nih.gov/research/parkinsonsweb/udall_centers/). Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published the autumn 2011 an expected receipt date January 2012. FOA utilize Specialized Center P50) activity code. Details the planned FOA provided below. Research Initiative Details goal this NINDS program to fund multidisciplinary research Centers Excellence will rapidly advance innovative research our understanding treatment Parkinson’s disease PD) related disorders. Udall Centers perform state-of-the-art research PD, including examination underlying neurobiological neuropathological mechanisms, identification characterization candidate disease-associated genes, establishment improved PD models development testing potential therapeutics, the initiation novel avenues clinical research. Centers Excellence, Udall Centers should serve regional national resources the study PD related parkinsonian disorders. Udall Centers program utilizes Specialized Center P50) grant mechanism, is designed support spectrum basic, translational clinical research activities utilizing integrated, multidisciplinary approach a specific disease entity biomedical problem area. overall theme the Center, proposed research projects integral resource Cores should relate directly the etiology, pathogenesis treatment PD related parkinsonian disorders. Notice encourages established investigators proven expertise and/or novel insights PD related disorders consider applying through upcoming FOA. Applications Principal Investigators currently pursuing PD research welcome their specific expertise, together proof project feasibility relevance, provide novel approaches the identification disease mechanisms therapeutic targets PD related disorders. Centers be expected contribute unique knowledge the ongoing network Udall Centers programs to collaborate within network. While basic research PD and continue serve the foundation discovery the Udall Centers program, proposed Center must include least one, small-scale, early translational research project. this context, translational research defined investigations focusing the development therapeutics, diagnostics, devices clinical criteria would ultimately lead new approaches the treatment PD. NINDS policy Udall Centers establishes following budget limits new competing renewal applications: applicants request maximum annual direct costs 1,000,000; requested budget 1,500,000 permitted inclusion a clinical component including research project plus supportive core). clinical component accompanying budget should clearly described specified. Full details be available the FOA. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Beth-Anne Sieber, PhD Program Director, Neurodegeneration Cluster Division Extramural Research National Institute Neurological Disorders Stroke 6001 Executive Boulevard, Room 2223 Bethesda, MD 20892-9525 Phone: 301) 496-5680 Email: sieberb@ninds.nih.gov

Improving Quality NINDS-Supported Preclinical Clinical Research through Rigorous Study Design Transparent Reporting Notice Number: NOT-NS-11-023 Key Dates Release Date: August 10, 2011 Related Announcements June 9, 2015 - Enhancing Reproducibility through Rigor Transparency. Notice NOT-OD-15-103. Issued National Institute Neurological Disorders Stroke NINDS) Purpose Developing effective treatments neurological disorders central the mission NINDS.  Notice highlights importance well-designed preclinical studies the foundation translating basic research discoveries such treatments. Before being evaluated the clinic, candidate therapeutics often tested animal cell culture models specific diseases.  recent years, is increasing awareness among neurological disease communities the predictive value preclinical research improved information made available study design, execution, analysis interpretation.  Examples the most critical elements a well-designed study summarized the NINDS website http://www.ninds.nih.gov/funding/grant_policy.htm). NINDS believes applications propose preclinical research, that based previous preclinical data, be greatly strengthened the design, execution, interpretation the proposed studies supporting data adequately described.  NINDS encourages investigators, whenever possible, address elements directly their applications. Investigators urged discuss issues program staff prior submission applications, especially applications will requesting 500,000 more direct costs any year, which applicants must seek agreement accept assignment NINDS least 6 weeks prior the anticipated submission NOT-OD-02-004). Inquiries Please direct inquiries to: Shai Silberberg, Ph.D. Program Director NINDS 6001 Executive Blvd., NSC Rm 2131 Bethesda, MD 20892 Phone: 301-496-1917 Email: SilberbS@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement NINDS Accelerated Awards Program Supporting Ancillary Studies PREDICT-HD U01) Notice Number: NOT-NS-11-022 Key Dates Release Date: August 5, 2011 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends publish Funding Opportunity Announcement FOA) solicit applications ancillary studies will further our understanding the unique clinical biomarker signatures premanifest Huntington's disease HD) through coordination the NINDS-funded Neurobiological Predictors Huntington's Disease PREDICT-HD) study. PREDICT-HD study an international 32-site observational study persons at-risk HD, includes clinical biospecimen resources 800 premanifest HD participants 200 healthy control subjects.  Extensive clinical data including UHDRS motor examination, cognitive neuropsychiatric assessments, structural MRI imaging been collected over ten-year time frame, a subset these data accessible through dbGaP website http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs… .  Biospecimen samples including plasma blood collected yearly stored the Coriell Institute Medical Research biorepository.  PREDICT-HD study cohort database offer unprecedented opportunity further examine distinct aspects premanifest HD.  During current final period funding the PREDICT-HD study, specific goals this FOA will: Coordinate pilot studies within existing infrastructure the PREDICT-HD study Facilitate standardized collection management biospecimen resources across sites funded projects Accelerate discovery validation HD biomarkers Promote development new clinical assessments clinical trial design premanifest HD Foster expand collaborative opportunities all stakeholders FOA encourage collaborative investigations combining expertise imaging, proteomics, assay development, clinical trial design, genetic variant modifier analysis, motor, neuropsychological cognitive assessments neurological disease.   Among areas research encouraged this initiative innovative informative clinical biomarker assessments designed improve translation existing knowledge towards efficient effective clinical trials the prevention treatment Huntington's disease. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  Investigators within outside the PREDICT-HD study be eligible apply.  Applications proposing additional clinical assessments must complete studies within remaining 3 year time frame September 1, 2011-August 31, 2014) PREDICT-HD.  Based the infrastructure available through PREDICT-HD, is anticipated responsive applications have direct costs 500k less per year. FOA expected be published October 2011 an initial application receipt date December, 2011. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Margaret Sutherland, PhD Program Director, Neurodegeneration Cluster NINDS 6001 Executive Blvd, NSC 2222 Bethesda, MD 20892 Phone: 301-496-5680 EMAIL : sutherlandm@ninds.nih.gov

Notice Correction PA-11-148  Nanoscience Nanotechnology Biology Medicine R01) Notice Number: NOT-EB-11-007 nbsp; Key Dates Release Date: August 1, 2011   Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Purpose purpose this Notice to correct Funding Opportunity Announcement PA-11-148, Nanoscience Nanotechnology Biology Medicine R01) http://grants.nih.gov/grants/guide/pa-files/PA-11-148.html ), published the NIH Guide March 14, 2011, indicate foreign institutions not eligible apply. Section III. Eligibility Information 1. Eligible Applicants Eligible Organizations Non-domestic non-U.S.) Entities Foreign Organizations) not eligible apply. Foreign non-U.S.) components U.S. Organizations not allowed. other aspects this FOA remain same. Inquiries Please direct inquiries to: Steven Zullo, Ph.D. National Institute Biomedical Imaging Bioengineering NIBIB) Phone: 301) 451-4774 Email: zullo@helix.nih.gov

Notice Intent Publish Request Applications Neurosurgeon  Research Career Development Program NRCDP) K12) Notice Number: NOT-NS-11-019 Key Dates Release Date: July 29, 2011 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications a Neurosurgeon Research Career Development Program NRCDP). goal the program to expand cadre neurosurgeon-researchers will combine clinical research expertise conduct research neurological disorders neurosurgeons uniquely qualified conduct. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published Fall 2011 an expected receipt date November 2011. FOA utilize K12 activity code. K12 be housed the PD/PI's institution, will support national program, overseen the PD/PI a national advisory committee. maximum one national K12 program be supported. Details the planned FOA provided below. Research Initiative Details Notice encourages investigators appropriate expertise stature begin consider applying this new FOA. Potential PD/PIs should nationally acknowledged leaders the neurosurgery community, should a history active, funded research, should a track record successfully training clinician-scientists. the application process, PD/PIs have recruit approximately 9 members the national advisory committee, of whom should acknowledged leaders their communities. advisory committee should consist primarily neurosurgeon-researchers, should also include leading researchers other communities, such neurology, clinical communities relevant neurosurgical research PhD neuroscientists an understanding disease-related research. goals the NRCDP program to provide support a period mentored training following residency, build networking collaborative infrastructure, to facilitate transition neurosurgeons mentored independent research positions. NRCDP provide neurosurgeons the experience, research support funding necessary initiate vigorous, sustainable research program. K12 program provide support mentored training neurosurgeon-researchers have moved a new institution following residency, beginning their first year a faculty position. Training occur the scholar's home institution, may anywhere the U.S.. scholar be supported the institution sponsors K12, the sponsoring institution not intended be unique training location. Training occur two phases, two year phase which scholar financially supported this K12 award a three year phase which scholar supported an individual NIH K award other source funding. entire 5 year period be overseen the NRCDP, will include yearly meeting those supported NRCDP scholars other junior neurosurgeon investigators, will focus career development, grant writing networking. Investigators interested applying response this FOA encouraged contact Dr. Stephen Korn, Director the NINDS Office Training, Career Development Workforce Diversity. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. Director Office Training, Career Development Workforce Diversity National Institute Neurological Disorders Stroke NINDS) 6001 Executive Boulevard, Room 2153  Bethesda, Maryland 20892 Phone: 301- 496-4188 Email: korns@ninds.nih.gov Website: http://www.ninds.nih.gov/funding/areas/training_and_career_development/…

Request Information RFI): Proposed Funding Priorities Neuroscience Research, Resources Tools NIH Neuroscience Blueprint) Notice Number: NOT-MH-11-016 Key Dates Release Date: July 21, 2011 Response Date: September 9, 2011 Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Institute Mental Health NIMH) National Eye Institute NEI) National Center Complementary Alternative Medicine NCCAM) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Office Behavioral Social Sciences Research OBSSR) Background is time-sensitive Request Information RFI) soliciting ideas the neuroscience research community how best support accelerate neuroscience research. Responses this RFI should pertinent the interests more one the NIH Neuroscience Blueprint Institutes listed above. Neuroscience research a unifying theme across NIH Institutes Centers. NIH Blueprint Neuroscience Research NIH Blueprint) launched 2004 16 participating Institutes Centers provide framework coordinating research, developing tools resources are broadly useful advancing neuroscience research http://neuroscienceblueprint.nih.gov/). pooling resources expertise, NIH Blueprint taking advantage economies scale confronting challenges too large any single NIH Institute Center. NIH Blueprint Resources Currently Available the Neuroscience Community NIH Blueprint presently its seventh year, has funded variety tools resources available the neuroscience community are broadly relevant across diseases participating NIH ICs. following website gives overview the NIH Blueprint activities underway resources available neuroscientists: http://www.neuroscienceblueprint.nih.gov/ Information Requested NIH Blueprint considering best invest funds future fiscal years. FY2012 FY2013, is anticipated limited funding be available year more 4 million) while FY2014 provide greater flexibility several NIH Blueprint projects to end. Keeping mind the NIH Blueprint interested ideas are broadly relevant across diseases participating ICs, responses requested the questions below: Identify areas neuroscience research could accelerated the development specific research resources tools. are major opportunities for, impediments to, advancing neuroscience research? are 2-3 highest priority tools resources needed capitalize the scientific opportunities overcome obstacles progress neuroscience research? Describe NIH Blueprint might best facilitate development these tools/resources. Confidentiality Responses this RFI voluntary will kept anonymous.  Any identifiers e.g., names, institutions, e-mail addresses, etc.) be removed responses compiled. Only processed, anonymized results be shared internally working groups convened the NIH Blueprint, appropriate. Proprietary, classified, confidential, sensitive information should be included your response. The Government reserves right use any non-proprietary technical information any resultant solicitation(s). NIH use information gathered develop grant, contract, other funding initiatives. RFI for information planning purposes only should be construed a solicitation as obligation the part the Federal Government, National Institutes Health NIH), individual NIH Institutes Centers. NIH does intend make any awards based responses this RFI pay the preparation any information submitted for Government's of such information. to Submit Response   comments must submitted electronically to:  nihblueprint@nih.gov. Responses this RFI be accepted through September 9, 2011. will receive electronic confirmation acknowledging receipt your response, will receive individualized feedback any suggestions.  basis claims against U.S. Government shall arise a result a response this request information from Government’s of such information. Inquiries Inquiries regarding Notice be directed to: Susan Marino, Ph.D. NIH Blueprint Executive Secretariat National Institute Neurological Diseases Stroke 31 Center Dr, Room 8A/52 MSC 2540 Bethesda, MD 20892-9641 Telephone:  (301) 596-4470 Email: nihblueprint@nih.gov

NINDS Parkinson's Disease Biomarkers Program Strategy Notice Number: NOT-NS-11-020 Update: following update relating this announcement been issued: September 1, 2011 - Notice NOT-NS-11-027. NINDS Request Information RFI) Creating Data Management Resource the Parkinson's Disease Biomarkers Program. Key Dates Release Date: July 15, 2011 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Recently, has considerable progress our understanding the biology Parkinson’s disease.  However, inadequate measures disease progression, limited ability detect neurodegeneration prior the onset motor signs, the lack assays measure target engagement potential therapeutics currently impede therapy development.  overcome obstacles, NINDS intends establish Parkinson’s Disease Biomarkers Program PDBP).  goal this program to facilitate development neuroprotective agents slow halt progression Parkinson’s disease.  providing shared, high quality resources, PDBP program coordinate efforts multiple stakeholders.  will serve a multi-faceted platform for:  1) integrating existing biomarker efforts, 2) standardizing data collection management across efforts, 3) accelerating discovery validation new biomarkers, 4) fostering expanding collaborative opportunities all stakeholders.  will facilitate both clinical laboratory-based discovery projects designed lead the validation candidate markers pre-symptomatic diagnosis monitoring disease progression. markers ultimately critical designing effective Phase II III clinical trials.  Initially, PDBP have three major components: 1) Funding discovery projects designed identify promising biomarkers.  Examples such projects include development validation assays candidate analytes the of well-defined cohort studies identify clinical, pathological, imaging biomarkers. studies must include consent language allows broad public sharing biological samples deposition data the resources described below. 2) contract-based resource the banking sharing existing prospective biological samples meet stringent inclusion criteria be described the funding announcements.  3) Data Management Resource DMR).  resource receive, process, distribute standardized clinical, imaging, biological, molecular data the discovery other Parkinson’s biomarkers projects.  Both positive negative data be included the DMR. accelerate pace discovery, sharing data biological samples be core feature the PDBP.  program have clear sharing requirements data biological samples will promote sharing as close real time" possible.  collaboration the Parkinson's disease research community, NINDS integrate its PD biomarker projects within program. Inquiries Please direct inquiries to: Program Contact: Katrina Gwinn MD National Institute Neurological Disorders Stroke National Institutes Health 6001 Executive Blvd Room 2143 Bethesda, MD 20892 EXPRESS/COURIER:  Rockville, MD 20852 Phone: 301); 496-5745 Fax: 301) 401-5301 Email: gwinnk@ninds.nih.gov

NINDS Policy the Requirement Authorization the Food Drug Administration FDA) use Investigational Drug, Biologic Product Device a Clinical Trial Prior Submission an Application Notice Number: NOT-NS-11-018 Update: following update relating this announcement been issued: July 22, 2013 - Issuance PAR-13-278, NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01). March 13, 2012 - Notice NOT-NS-12-007. NINDS Policy Submission Applications Containing Clinical Trials. Key Dates Release Date: July 15, 2011 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform NINDS grant applicants that, beginning applications intended the September 25, 2011 due date beyond, following conditions related FDA regulations must met before NINDS allow submission an application involving clinical trial scientific technical review. Notice applies grant applications submitted under Exploratory Clinical Trials FOA PAR-10-199 http://grants.nih.gov/grants/guide/pa-files/PAR-10-199.html) the Phase III Clinical Trials FOA PAR-11-173 http://grants.nih.gov/grants/guide/pa-files/PAR-11-173.html) all subsequent NINDS FOAs where clinical trials FDA regulated interventions be proposed”. the time grant submission, applicants must provide documentation the FDA providing information one the following three scenarios: A)  protocol been submitted under open IND/IDE the IND/IDE not under full partial hold.  Under scenario, applicants must provide documentation such a proceed” email letter the FDA. B)  protocol been submitted under IND/IDE is full partial hold.  Under scenario applicants must provide full documentation the FDA the reasons hold the FDA recommendations. C)  protocol exempt an IND/IDE.  Under scenario applicants must provide copy the exemption letter the FDA. Applications do include information described under scenarios A), B), C) be withdrawn not reviewed.  Prior grant award NINDS require awardees do have previously documented study exemption provide documentation their IND/IDE remains open that has been placed under full partial hold. purposes this policy, clinical trial defined NIH policy http://grants.nih.gov/grants/policy/nihgps_2010/index. htm) a biomedical research study human subjects is designed answer specific questions biomedical interventions drugs, treatments, devices, new ways using known drugs, treatments, devices). Clinical trials used determine whether new interventions safe effective”. Inquiries Inquiries concerning policy should sent to: Scott Janis, Ph.D. Office Clinical Research National Institute Neurological Disorders Stroke Room 2170, MSC 9525 6001 Executive Blvd. Bethesda, MD 20892-9525 Telephone: 301) 496-9135 Fax: 301) 410-1080 Email: janiss@ninds.nih.gov D Elizabeth McNeil, M.D. MSc Office Clinical Research National Institute Neurological Disorders Stroke Room 2215, MSC 9520 6001 Executive Blvd. Bethesda, MD 20892-9520 Telephone: 301) 496-9135 Fax: 301) 410-1080 Email: mcneilde@ninds.nih.gov inquiries review issues contact: Chief, Scientific Review Branch National Institute Neurological Disorders Stroke Room 3201, MSC 9529 6001 Executive Blvd. Bethesda, MD 20892-9529 Telephone: 301) 496-9223 Fax: 301) 402-0182 Email: nindsreview@ninds.nih.gov

NCCAM Termination Participation F31 Program Notice Number: NOT-AT-11-004 Key Dates Release Date:   June 30, 2011 Issued National Cancer Institute NCI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH formerly NCCAM) Purpose is inform scientific community NCCAM no longer participate the Ruth L. Kirschstein National Research Service Awards NRSA) Individual Predoctoral Fellows Parent F31) Parent F31) PA-11-111) program. last receipt date new non AIDS F31 applications NCCAM August 8, 2011, September 7, 2011 AIDS related applications; last receipt date resubmissions non AIDS F31 applications NCCAM April 8, 2012 AIDS-related applications May 7, 2012. other aspects PA-11-111 remain unchanged. NCCAM continue offer support pre-doctoral students through Ruth L. Kirschstein National Research Service Awards Individual Predoctoral Fellowships Promote Diversity Health-Related Research Parent F31 - Diversity)(PA-11-112), Ruth L. Kirschstein NRSA Institutional Research Training Grants Parent T32) PA-11-184) the Ruth L. Kirschstein NRSA Short-Term Institutional Research Training Grants Parent T35) PA-11-185). Additionally, investigators continue include support pre-doctoral students NCCAM research project grants e.g., R01, U01, R21, P01, U19, etc.). Inquiries Please direct inquiries to: Partap S. Khalsa, DC, PhD, Acting Training Officer National Center Complementary Alternative Medicine 6707 Democracy Boulevard, Suite 401, Bethesda, MD 20892 301/594-3462 partap.khalsa@nih.gov www.nccam.nih.gov

Notice NIH Participation the National Robotics Initiative NRI) Notice Number: NOT-EB-11-006 Update: following update relating this announcement been issued: September 21, 2012 - Updates the NRI - Notice updates supersedes previous Guide Notice,NOT-EB-11-006. Notice NOT-EB-12-006. Key Dates Release Date: June 24, 2011 Issued National Institutes Health NIH)      National Institute Biomedical Imaging Bioengineering NIBIB)      National Institute Aging NIA)      Eunice Kennedy Shriver National Institute Child Health Human Development NICHD)     National Institute Nursing Research NINR)     National Institute Neurological Disorders Stroke NINDS)     National Center Research Resources NCRR) National Science Foundation NSF) National Aeronautics Space Administration NASA) U.S. Department Agriculture USDA) Purpose purpose this Notice to announce the NIH collaborating a multi-agency funding opportunity, National Robotics Initiative NRI) http://www.nsf.gov/nri), whose goal to accelerate development use robots the United States work beside, cooperatively with, people http://www.nsf.gov/publications/pub_summ.jsp?WT.z_pims_id=503641&ods_ke…).  Innovative robotics research applications emphasizing realization such co-robots acting direct support a human supported multiple agencies the federal government including National Institutes Health NIH), National Science Foundation NSF), National Aeronautics Space Administration NASA), the U.S. Department Agriculture USDA). initiative facilitate development the next generation robotics, particularly co-robotics, encourage existing new communities focus innovative application areas. Collaboration between academic, industry, non-profit other organizations strongly encouraged establish better linkages between fundamental science technology development use.  NIH areas interest include, are limited to, robotics home care; personalized care special needs populations robotic wellness/health promotion; robot-assisted recovery; rehabilitation behavioral therapy; surgical interventional robots; high-throughput robotic technologies. Award Information Award sizes NIH funded research projects expected range approximately 100,000 250,000 per year direct costs, durations one five years.  award exceed 250,000 per year direct costs. Estimated program budget, number awards average award size duration subject the availability funds.  Determination awards based three criteria: 1) availability funds, 2) program priorities, 3) scientific merit. Subsequent grant administration procedures be accordance the policies the awarding Institute. Application Preparation Submission Instructions Applications submitted response this program announcement/solicitation should prepared submitted accordance the general guidelines contained the NSF Grant Proposal Guide GPG).  Applications must submitted the NSF, to NIH.  complete text the GPG available electronically the NSF Web Site at: http://nsf.gov/publications/pub_summ.jsp?ods_key=gpg.   Applicants reminded identify NSF program announcement number the program announcement block the NSF Cover Sheet Proposal the National Science Foundation.  Compliance this announcement critical determining relevant application processing guidelines.  Failure submit information delay processing. Budgetary Information Cost sharing not required applications submitted this funding opportunity. Budgets should include travel funds the PD/PI team members attend annual NRI Principal Investigators' meeting. NIH Process goal this activity to involve multiple agencies using application one review. meet NIH requirements, those applications are identified potential funding participating NIH Institutes Centers ICs), applicant organization be required submit R01application an NIH-approved format directly the Center Scientific Review http://www.csr.nih.gov/) the NIH.  PD/PIs invited submit NIH receive further information submission procedures the NIH. NIH application not allowed increase proposed budget change scientific content the application the converted submission the NIH. The summary statement be presented the involved IC's National Advisory Council the second level review. Subsequent the Council review, NIH ICs make funding determinations selected awards be made. Grant administration procedures NIH awardees, including those related New Early Stage Investigators http://grants.nih.gov/grants/new_investigators/) be accordance the policies NIH. Please note applications be submitted review the NSF November 3, 2011. Notification applications selected potential funding the participating NIH ICs be received the end March, 2012.  converted submission NIH be due April 11, 2012, will an extremely short conversion time.  applicant organization want work closely their Sponsored Programs Office assure timely submission during narrow submission window. earliest project start date be July 1, 2012. Inquiries Written telephone inquiries encouraged.  NIH Program contacts listed below. Please the NSF program announcement names contact information each the participating NSF Directorates http://www.nsf.gov/nri. John W. Haller, Ph.D., National Institute Biomedical Imaging Bioengineering 6707 Democracy Blvd., Bethesda, MD 20892 Telephone: 301.451.4780;  Fax: 301.480.4973 Email: hallerj@mail.nih.gov; http://www.nibib.nih.gov Lyndon Joseph, Ph.D Health Scientist Administrator Division Geriatrics Clinical Gerontology National Institute Aging, NIH, DHHS 7201 Wisconsin Avenue, Suite 3C307 Bethesda, MD 20892-9205 Telephone: 301-496-6926 Fax: 301-402-1784 Email: Josephlj@nia.nih.gov       www.nia.nih.gov Louis Quatrano, Ph. D. Program Director, BSRE, NCMRR Eunice Kennedy Shriver National Institute Child Health Human Development National Institutes Health 6100 Executive Blvd, Rm 2A03, MSC 7510, Bethesda, MD 20892-7510 Rockville, MD 20852 express/courier service) Office:  301-402-4221 Fax:  301-402-0832 Email: quatranl@mail.nih.gov   Paul A. Cotton, PhD, RD, Program Director National Institute Nursing Research NINR) 6701 Democracy Blvd, Ste. 710 Democracy Plaza Bethesda, MD 20892-4870 Courier zip: 20817) Phone: 301.402.6423 Fax:      301.451.5647 Email: Paul.Cotton@nih.gov;    http://www.ninr.nih.gov/ Daofen Chen,  Ph.D. Program Director Systems Cognitive Neuroscience National Institute Neurological Disorders Stroke NINDS/NIH) NIH Neuroscience Center, Room 2176 6001 Executive Boulevard Bethesda, MD 20892-9523 (FEDEX 20852) Phone: 301) 496-9964, FAX: 301) 402-1501 Email: daofen.chen@nih.gov