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NIH is accepting administrative supplement requests to support projects that will establish or improve interoperability among NIH funded biomedical data repositories. Improved interoperability is expected to lead to increased efficiency of repositories operations and cost reductions, which are significant factors of the NIHs long-term sustainability plans for the biomedical data repositories.

The Office of AIDS Research, in collaboration with the NIH Institutes and Centers (ICs) named above, encourages applications for administrative supplements to fund innovative research on HIV and aging through clinical, translational, observational, or interventional studies in domestic or international settings. The specific types of NIH awards that can be supplemented are listed above. Supplemental projects must be within the scope of the parent grant. Topics of interest include HIV infection, HIV-associated conditions, HIV treatment, and/or biobehavioral or social factors associated with HIV/AIDS in the context of aging and/or in older adults.

The purpose of this FOA is to support the development of Mobilizing Research a research resource that would allow researchers to more efficiently and rapidly evaluate mobile and wireless (mHealth) technologies. This research resource is intended to develop an infrastructure that works with wireless carriers to create a registry of potential participants to facilitate mHealth research across a variety of observational and clinical research studies and settings, and for a range of diseases and populations. This FOA supports Mobilizing Research for development of the infrastructure and transition to sustainability. Therefore, the proposed integrated and centralized resource should be designed and operated in a way that will facilitate and enable its sustainable functioning in the near future.

The purpose of this Big Data to Knowledge funding opportunity (FOA) announcement is to support the development of new or significantly adapted interactive digital media that engages the public, experts or non-experts, in performing some aspect of biomedical research via crowdsourcing. To be responsive to this FOA, each application is expected to pose a challenging biomedical research problem and propose the development of engaging interactive digital media that incorporates crowdsourcing as a fundamental component of how the problem is solved. The biomedical research problem should be amenable to one or more human computation approaches, as the users must be active participants in the analysis and/or interpretation of data, rather than acting primarily as data collectors or sources of data.

In this Funding Opportunity Announcement (FOA) we seek applications through the Small Business Innovation Research (SBIR) program for the optimization of existing and emerging technologies and approaches including 1) technologies and novel approaches for large scale recording and manipulation of neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain, 2) tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development with an end-goal of broad dissemination and incorporation into regular neuroscience practice.

This Funding Opportunity Announcement (FOA) is issued as an initiative of the NIH Blueprint for Neuroscience Research.The Neuroscience Blueprint is a collaborative framework through which 15 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/).The Neuroscience Blueprint is supporting a Lifespan Human Connectome Project (L-HCP) to extend the Human Connectome Project (HCP) (http://www.neuroscienceblueprint.nih.gov/connectome) to map connectivity in the developing, adult, and aging human brain.The goal of this FOA is to solicit grant applications that propose to extend the experimental protocols developed through the HCP to children and adolescents to investigate the structural and functional changes that occur in the brain during typical development.A companion FOA is soliciting applications that apply the HCP protocols to middle age and elderly adults to explore changes that occur during normal aging.

This Funding Opportunity Announcement (FOA) is issued as an initiative of the NIH Blueprint for Neuroscience Research. The Neuroscience Blueprint is a collaborative framework through which 15 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/). The Neuroscience Blueprint is supporting a Lifespan Human Connectome Project (L-HCP) to extend the Human Connectome Project (HCP) (http://www.neuroscienceblueprint.nih.gov/connectome) to map connectivity in the developing, adult, and aging human brain. The goal of this FOA is solicit grant applications that propose to extend the experimental protocols developed through the HCP to middle-age and elderly adults to investigate the structural and functional changes that occur in the brain during typical aging. A companion FOA is soliciting applications that apply the HCP protocols to children and adolescents to explore changes that occur during typical development.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. The program will utilize a cooperative agreement mechanism to support the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and a subsequent small clinical study (e.g., Early Feasibility Study). The small clinical study should provide data to answer key questions about the function or final design of a device.This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study.

The purpose of this FOA is to encourage applications to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study).Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board, or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants.The clinical study should provide data to answer key questions about the function or final design of a device.This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.

A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. Available technologies for recording and manipulating neural circuit activity in human and animal experiments are not sufficient to accomplish this goal. Non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise. Invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Previous BRAIN FOAs sought to develop novel technology (RFA-NS-15-003) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-15-004). This FOA seeks applications for technology at an even earlier stage of development. It seeks new and untested ideas that are in the very earliest stages. The support provided might enable calculations, simulations, computational models, or other mathematical approaches for demonstrating that the signal sources and/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models. Invasive or non-invasive approaches are sought that will ultimately enable or reduce the current barriers to large-scale recording or manipulation of neural activity, and that would be compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individuals, including physicists, engineers, theoreticians, and scientists, especially those not typically involved with neuroscience research.