Robyn Klein, M.D.,Ph.D.

Research Program Award (R35)
Image
photo of Robyn Klein
Institution
Washington University, St. Louis, MO

Dr. Klein studies the role that alterations in synaptic connections and in methods of repair play in the disruption of neuronal networks during recovery from viral infections. Her lab will utilize novel rodent models of post-infectious cognitive dysfunction to elucidate the roles and regulation of innate immune molecules involved in spatial learning. In addition to these models, Dr. Klein will employ genetic, pharmacologic and imaging, single-cell sequencing, and fate mapping techniques, and the use of bone marrow chimeras in her work. Her research will improve our understanding of the molecular neuroimmunological regulation of synapses, T cell and glial interactions, and, more broadly, neurogenerative and other disorders of memory.