Dr. Klann examines how signaling pathways regulate translation during memory processes. His current project will seek to understand the requirements for de novo protein synthesis in memory consolidation. Using genetically engineered mice and viruses, electrophysiological recordings, immune-cytochemistry, innovative methods to measure de novo protein synthesis in vivo, cell-type specific translational profiling, and de novo proteomics, Dr. Klann will identify which cells require de novo translation in auditory and contextual threat memory. He will also examine dysregulated translation in neurodegenerative and neurodevelopmental disorders. His research will provide insights into the molecular mechanisms of consolidation, reconsolidation, and extinction of memory.