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The National Institute of Neurological Disorders and Stroke (NINDS), the Trans-NIH Xenopus Working Group, the National Institute of Child Health and Human Development (NICHD), the National Institute of Environmental Health Sciences (NIEHS), the National Institute of General Medical Sciences (NIGMS), and the National Institute of Mental Health (NIMH) request applications for research to examine the feasibility of using Xenopus tropicalis for standard genetic manipulation.

The objective of this request for applications (RFA) is to solicit applications to develop critical research tools and resources for Xenopus tropicalis. The amphibian has a long and illustrious history as a major system for elucidating cellular and developmental processes. The Xenopus has been the predominant amphibian used because it possesses unique advantages including the production of large embryos in large numbers, external development, and rapid development.

Potential areas of research include insertional mutagenesis and chemical mutagenesis. Phenotypes of interest include alterations in: embryonic patterning; organogenesis and organ function; limb formation and patterning; the expression pattern of known genes; nervous system development and function, and potential models of neurological disorders; and toxicity (due to environmental/industrial chemicals/agents).

APPLICATION RECEIPT DATE: July 11, 2001.

For more information, potential applicants should contact Dr. Robert Finkelstein, Program Director, Neurogenetics Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2136, Bethesda, MD 20892; telephone: (301) 402-1501; fax: (301) 496-5748; e-mail: rf45c@nih.gov.

For a more detailed description of this RFA, please visit the web site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-01-008.html.

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This content has been adapted from the original NINDS Notes publication. For the most up-to-date funding information, please visit the Funding Opportunities section of the NINDS web site.  For the most recent information on NINDS studies, please visit the NINDS Patient Recruitment web site.