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Edward H Oldfield M.D., Senior Investigator
Dr. Oldfield received his M.D. from the University of Kentucky Medical School, training in general surgery (1973-75) at Vanderbilt University and in neurology (1975-76) at the National Hospital for Nervous Disease, London, England. He returned to Vanderbilt for training in neurosurgery (1976-1980). In 1984 he became chief of the Clinical Neurosurgery Department in the Surgical Neurology Branch in NINDS. In 1995 he was awarded the Grass Medal from the Society of Neurological Surgeons and in 1999 he received the Farber Award of the American Association of Neurological Surgeons. His branch performs basic and clinical research in the areas of brain and pituitary tumors, syringomyelia, the development of new drug delivery techniques for the central nervous system, and certain types of vascular disorders of the central nervous system.
Laboratory Staff
Ashok Asthagiri, M.D. Staff Clinician 301-594- 3102
Hetty DeVroom, R.N. Nurse 301-594- 8111
Nancy Edwards, B.S. Research Assistant 301-496- 6720
John Heiss, M.D. Staff Clinician 301-594- 8112
Barbara Ikejiri, B.S. Research Assistant 301-402- 4244
Khalid Kurtom, M.D. Clinical Fellow 301-594- 6053
Jie Li, M.D., Ph.D. Research Fellow 301-402- 4253
Russell Lonser, M.D. Staff Clinician
Jie Lu, M.D., Ph.D. Visiting Fellow 301-402- 4244
Marsha Merrill, Ph.D. Investigator 301-496- 6720
Ryszard Pluta, M.D., Ph.D. Staff Scientist 301-594- 8120
Rene Smith, R.N. Nurse 301-594- 8108
Debbie Song, M.D. Clinical Fellow 301-594- 8121
Dana Taylor, Secretary 301-496- 5728
Alexander Vortmeyer, M.D. Staff Scientist 301-594- 2914
Stuart Walbridge, B.S. Research Assistant 301-496- 1155
Bryan Walker, Physician Assistant 301-594- 8119
Ping Zhuang, M.D. Staff Scientist 301-435- 8445
Research Interests
Clinical studies of conditions involving neurosurgical intervention, including brain tumors, pituitary tumors, syringomyelia, von Hippel-Lindau disease, and arteriovenous malformations of the spinal cord are ongoing. Activities include investigation of a new delivery technique to perfuse targeted regions of the brain. We have developed and used this technique in a clinical study using recombinant immunotoxins to treat malignant brain tumors. We have completed laboratory studies using excitotoxins to selectively eliminate neuronal cell populations in models of epilepsy and Parkinson's disease. Clinical studies are being developed to use this technique in the investigation of patients with medically intractable epilepsy and in the treatment of patients with Parkinson's disease. The genetics of familial Chiari I malformation is being examined. Potential therapeutic uses of nitric oxide for cerebral vasospasm and opening of the blood-brain barrier are being investigated. The Surgical Neurology Branch offers a two-year combined basic science and clinical fellowship. Selected Recent PublicationsVortmeyer AO, Huang SC, Pack SD, Kock CA, Lubensky IA, Oldfield EH, Zhuang Z
Somatic point mutation of the wild-type allele detected in tumors of patients with VHL germline deletion - Oncogene 21(8) 1167-70 2002 Lonser RR, Walbridge S, Garmestani K, Butman J, Walters HA, Vortmeyer AO, Morrison PF, Brechbeil MW, Oldfield EH
Successful and safe perfusion of the primate brainstem: in vivo magnetic resonance imaging of macromolecular distribution during infusion - J Neurosurg 97 905-913 2002 Watson JC, Gorbach AM, Pluta RM, Rak R, Heiss JD, Oldfield EH
Real-time detection of vascular occlusion and reperfusion of the brain during surgery by using infrared imaging - J Neurosurg 96 918-923 2002 Pace JR, Lonser RR, Kirkby RD, Jeffries N, Rogawski MA, Oldifield EH
Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy - J Neurosurg 97 450-454 2002 Weil RJ, Vortmeyer AO, Zhuang Z, Pack S, Theodore N, Erickson RK, Oldfield EH
Clinical and molecular analysis of disseminated hemangioblastomatosis of the central nervous system in patients without von Hippel-Lindau disease. - J Neurosurg 96 775-787 2001 Weil RJ, Zhuang Z, Pack S, Kumar S, Helman L, Fuller BG, Mackall CL, Oldfield EH
Intramedullary Ewing's sarcoma of the spinal cord: consequences of molecular diagnostics - J Neurosurgery 95 270-275 2001
Contact Information
Clinical Neurosurgery Section Surgical Neurology Branch, NINDS Building 10, Room 5D37 10 Center Drive, MSC 1414 Bethesda MD 20892-1414
Telephone: - - (office), - - (laboratory), - - (fax), Email: oldfielde@ninds.nih.gov
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Edward H Oldfield M.D., Senior Investigator
Dr. Oldfield received his M.D. from the University of Kentucky Medical School, training in general surgery (1973-75) at Vanderbilt University and in neurology (1975-76) at the National Hospital for Nervous Disease, London, England. He returned to Vanderbilt for training in neurosurgery (1976-1980). In 1984 he became chief of the Clinical Neurosurgery Department in the Surgical Neurology Branch in NINDS. In 1995 he was awarded the Grass Medal from the Society of Neurological Surgeons and in 1999 he received the Farber Award of the American Association of Neurological Surgeons. His branch performs basic and clinical research in the areas of brain and pituitary tumors, syringomyelia, the development of new drug delivery techniques for the central nervous system, and certain types of vascular disorders of the central nervous system.
Laboratory Staff
Ashok Asthagiri, M.D. Staff Clinician 301-594- 3102
Hetty DeVroom, R.N. Nurse 301-594- 8111
Nancy Edwards, B.S. Research Assistant 301-496- 6720
John Heiss, M.D. Staff Clinician 301-594- 8112
Barbara Ikejiri, B.S. Research Assistant 301-402- 4244
Khalid Kurtom, M.D. Clinical Fellow 301-594- 6053
Jie Li, M.D., Ph.D. Research Fellow 301-402- 4253
Russell Lonser, M.D. Staff Clinician
Jie Lu, M.D., Ph.D. Visiting Fellow 301-402- 4244
Marsha Merrill, Ph.D. Investigator 301-496- 6720
Ryszard Pluta, M.D., Ph.D. Staff Scientist 301-594- 8120
Rene Smith, R.N. Nurse 301-594- 8108
Debbie Song, M.D. Clinical Fellow 301-594- 8121
Dana Taylor, Secretary 301-496- 5728
Alexander Vortmeyer, M.D. Staff Scientist 301-594- 2914
Stuart Walbridge, B.S. Research Assistant 301-496- 1155
Bryan Walker, Physician Assistant 301-594- 8119
Ping Zhuang, M.D. Staff Scientist 301-435- 8445
Research Interests
Clinical studies of conditions involving neurosurgical intervention, including brain tumors, pituitary tumors, syringomyelia, von Hippel-Lindau disease, and arteriovenous malformations of the spinal cord are ongoing. Activities include investigation of a new delivery technique to perfuse targeted regions of the brain. We have developed and used this technique in a clinical study using recombinant immunotoxins to treat malignant brain tumors. We have completed laboratory studies using excitotoxins to selectively eliminate neuronal cell populations in models of epilepsy and Parkinson's disease. Clinical studies are being developed to use this technique in the investigation of patients with medically intractable epilepsy and in the treatment of patients with Parkinson's disease. The genetics of familial Chiari I malformation is being examined. Potential therapeutic uses of nitric oxide for cerebral vasospasm and opening of the blood-brain barrier are being investigated. The Surgical Neurology Branch offers a two-year combined basic science and clinical fellowship. Selected Recent PublicationsVortmeyer AO, Huang SC, Pack SD, Kock CA, Lubensky IA, Oldfield EH, Zhuang Z
Somatic point mutation of the wild-type allele detected in tumors of patients with VHL germline deletion - Oncogene 21(8) 1167-70 2002 Lonser RR, Walbridge S, Garmestani K, Butman J, Walters HA, Vortmeyer AO, Morrison PF, Brechbeil MW, Oldfield EH
Successful and safe perfusion of the primate brainstem: in vivo magnetic resonance imaging of macromolecular distribution during infusion - J Neurosurg 97 905-913 2002 Watson JC, Gorbach AM, Pluta RM, Rak R, Heiss JD, Oldfield EH
Real-time detection of vascular occlusion and reperfusion of the brain during surgery by using infrared imaging - J Neurosurg 96 918-923 2002 Pace JR, Lonser RR, Kirkby RD, Jeffries N, Rogawski MA, Oldifield EH
Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy - J Neurosurg 97 450-454 2002 Weil RJ, Vortmeyer AO, Zhuang Z, Pack S, Theodore N, Erickson RK, Oldfield EH
Clinical and molecular analysis of disseminated hemangioblastomatosis of the central nervous system in patients without von Hippel-Lindau disease. - J Neurosurg 96 775-787 2001 Weil RJ, Zhuang Z, Pack S, Kumar S, Helman L, Fuller BG, Mackall CL, Oldfield EH
Intramedullary Ewing's sarcoma of the spinal cord: consequences of molecular diagnostics - J Neurosurgery 95 270-275 2001
Contact Information
Clinical Neurosurgery Section Surgical Neurology Branch, NINDS Building 10, Room 5D37 10 Center Drive, MSC 1414 Bethesda MD 20892-1414
Telephone: - - (office), - - (laboratory), - - (fax), Email: oldfielde@ninds.nih.gov